Eczema Research

There are treatments to alleviate the symptoms of eczema but there is no cure for the condition. Children with atopic eczema may often grow out of it as they age. Several new therapies are being tried in this condition that may severely affect the quality of life in an individual.


There are several immunomodulators or immunosuppressants like topical calcineurin inhibitors (e.g. pimecrolimus and tacrolimus) that are now being used in severe eczema. Many other agents that modulate the local immune system to treat eczema and its symptoms are being tried in various clinical trials.

Gene therapy

As the condition is often related to family history and personal history of allergies, genes may be associated with eczema. Gene therapy of genetic engineering is a new avenue of research in eczema.

The body has its own protease inhibitors, such as, LEKTI, produced from the gene SPINK5 that protect it against damage from the enzymatic activity of allergens. Mutations in this gene are known to cause Netherton’s syndrome, which is a congenital erythroderma. These patients nearly always develop atopic disease, including hay fever, food allergy, urticaria and asthma. This could open new avenues for the understanding of eczema and its treatment.

Another gene has been identified that researchers believe to be the cause of inherited eczema and some related disorders. The gene produces the protein filaggrin, the lack of which causes dry skin and impaired skin barrier function.

Brain-derived neurotrophic factor (BDNF) and Substance P

These two chemical mediators in the body have recently been found to be associated with itching sensations associated with eczema. Studies in this direction have the potential to unfold a greater understanding of the pathology and newer development of medications to treat the condition.

Brain-derived neurotrophic factor, also known as BDNF, is a secreted protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the "neurotrophin" family of growth factors, which are related to the canonical "Nerve Growth Factor", NGF. Neurotrophic factors are found in the brain and the periphery.

In the field of neuroscience, substance P (SP) is a neuropeptide: an undecapeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykinin neuropeptide family. Substance P and its closely related neuropeptide neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene.

Epidemiological studies

In general, allergic conditions are on the rise. In England a study showed a 42% rise in diagnosis of the condition between 2001 and 2005, by which time it was estimated to affect 5.7 million adults and children. Whether the cause lies in genes or in the environmental factors is an avenue of research that is being explored by researchers.

Further Reading

Last Updated: Jun 4, 2019

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2019, June 04). Eczema Research. News-Medical. Retrieved on November 30, 2022 from

  • MLA

    Mandal, Ananya. "Eczema Research". News-Medical. 30 November 2022. <>.

  • Chicago

    Mandal, Ananya. "Eczema Research". News-Medical. (accessed November 30, 2022).

  • Harvard

    Mandal, Ananya. 2019. Eczema Research. News-Medical, viewed 30 November 2022,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
You might also like...
Study highlights the efficacy of MVA-BN booster vaccination in inducing durable B cell memory responses against monkeypox