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Using single B cell screening to boost antibody discovery

The Cyto-Mine® platform by Fluidic Sciences and Sphere Bio utilizes innovative picodroplet-based technology to capture and screen antibodies directly from entire B cell repertoires, maintaining cell viability and greatly enhancing efficiency.

B cell screening

Image Credit: Fluidic Sciences and Sphere Bio

In this eBook, Fluidic Sciences and Sphere Bio introduces a fast and reliable single B cell screening technique that identifies antibodies with specific antigenic properties, eliminating the need for the traditional, time-consuming hybridoma screening process.

Fluidic Sciences and Sphere Bio’ Cyto-Mine® platform, harnesses proprietary picodroplet-based technology to capture and screen antibodies directly from whole B cell repertoires, preserving cell viabilities and dramatically improving efficiencies.

This approach allows researchers to pinpoint antibody-secreting cells and isolate rare cells that produce antigen-specific antibodies within just two days, greatly speeding up the development process and reducing the time to market for new therapeutics.

Download the full eBook now to read more.

Image Credit: Fluidic Sciences and Sphere Bio

About Fluidic Sciences and Sphere Bio

Fluidic Sciences develops transformative in‑solution technologies for protein interaction analysis. Its flagship Fluidity One‑M instrument leverages Microfluidic Diffusional Sizing (MDS) to measure binding affinity, stoichiometry, size, and concentration without immobilization - directly in complex backgrounds such as serum, plasma, and lysate.

Sphere Bio is a brand of Fluidic Sciences. Its technology develops and manufactures single‑cell analysis and monoclonality assurance systems that enable researchers to find, analyze, and isolate the most valuable cells with speed and precision. Its proprietary picodroplet microfluidics and Cyto‑Mine® Chroma multiplexing platform power applications across antibody discovery, cell line development, cell engineering, and cell therapy.


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