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Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

Established in 2004, process analytical technology (PAT), a quality assurance program for the pharmaceutical industry developed by the US Food and Drug Administration, enables pharmaceutical manufacturers to control critical process parameters (CPPs).

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 25 Jan 2023

New method analyzes long-range interactions in the interactome

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material.

25 Jan 2023

Labeling the carbon footprint of food prompts more sustainable eating behavior

A field trial has shown that labeling the carbon footprint of food prompts people to eat more sustainably.

25 Jan 2023

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

The potential "tripledemic" of influenza, SARS-CoV-2 and RSV (respiratory syncytial virus) infection continues to be a concern.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

It's clear that chronic stress can impact our behavior, leading to problems like depression, reduced interest in things that previously brought us pleasure, even PTSD.

24 Jan 2023

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

A study published in the journal PNAS reveals that the gut microbiome stabilizes the synchronization between gut and brain circadian rhythms.

24 Jan 2023

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Researchers at the University of Pittsburgh School of Medicine, U.S. present the first evidence of 12-hour cycles of gene activity in the human brain. Publishing in the open access journal PLOS Biology on January 24th, the study led by Madeline R. Scott also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia.

24 Jan 2023

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Novel amyloid protein discovered from canine mammary tumors

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors.

24 Jan 2023

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide.

24 Jan 2023

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work – until now.

23 Jan 2023

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Aston University scientists are working with start-up company, Isterian Biotech, part of Cambrian BioPharma, to develop novel drugs to treat fibrotic diseases such as lung disease.

23 Jan 2023

Consuming soy flour rich in protein B-conglycinin could reduce LDL cholesterol levels

A protein in soybeans blocks the production of a liver enzyme involved in the metabolism of triglycerides and low-density lipoprotein, scientists found in a recent study.

23 Jan 2023

Novel method makes genetic analyses possible for all regions of the intestine

With its length and multitude of folds and protrusions, the intestine represents the largest contact surface between our body and the food taken up from the outside.

23 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

Hypertension drug can extend lifespan and slow aging

Researchers have found that the drug rilmenidine can extend lifespan and slow aging.

23 Jan 2023

Ingenza collaborates with Amplifica to advance novel alopecia treatments

Industrial biotech specialist Ingenza is delighted to announce that it is collaborating with clinical-stage biopharmaceutical company Amplifica Holdings Group, Inc. to develop an innovative treatment to address androgenic alopecia.

From Ingenza Ltd 23 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Life Science News

Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

New method analyzes long-range interactions in the interactome

Labeling the carbon footprint of food prompts more sustainable eating behavior

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Study uncovers protein that acts as a brake for DNA replication

Novel amyloid protein discovered from canine mammary tumors

Researchers develop a simple new assay to eliminate heteroresistance in Enterobacter species

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Consuming soy flour rich in protein B-conglycinin could reduce LDL cholesterol levels

Novel method makes genetic analyses possible for all regions of the intestine

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

Hypertension drug can extend lifespan and slow aging

Ingenza collaborates with Amplifica to advance novel alopecia treatments

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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