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Study paves new way to develop a predictive biomarker for TRAIL therapy

A cytokine named TRAIL binds to TRAIL receptors and kills cancer cells, but not normal cells. Therefore, various anticancer drugs targeting TRAIL receptors have been developed and gained great attention as a promising cancer therapeutics, but a certain population of cancer patients does not respond to the therapy.

15 Aug 2022

Researchers engineer artificial replicas of G protein-coupled receptors

How do signals from outside the cell cause a response inside it? Such outside signals could be hormones or neurotransmitters. To notice them, the cell's surface possesses receptors. One of the key classes of such receptors are so-called G protein-coupled receptors, or in short GPCRs.

15 Aug 2022

Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

Three genetic alterations associated with a rare seizure and a movement disorder primarily found in children were successfully mirrored in mice and their symptoms treated, in a new study from a University of Maryland School of Medicine researcher, Andrea Meredith, PhD, Professor of Physiology and her collaborators.

15 Aug 2022

In monkeys, spike-based vaccines produce some immunity based on CD8 T-cells

Scientists evaluate the role of CD8+ T-cells in vaccine protection against SARS-CoV-2 infection in rhesus macaques.

14 Aug 2022

Why is COVID-19 more severe in people older than 50?

A new study reports that the reduced efficiency of the immune response against SARS-CoV-2 could be due to the reduced diversity of both B- and T-cells.

14 Aug 2022

Men exposed to industrial air pollution exhibit sperm mitochondrial DNA deletions

Researchers compare the length spectra of sperm mitochondrial DNA deletions in two seasons with varied air pollution levels.

14 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.

12 Aug 2022

New method for 3D culture accurately quantifies how cancer cells generate forces to spread within tissue

Research to understand how cancers grow and spread has conventionally been done on two-dimensional, flat cultures of cells, which is very different to the three-dimensional structure of cells in the body.

12 Aug 2022

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Now, a group of prominent scientists and physicians are urging the FDA to include in its guidance to vaccine developers a recommendation for T-cell assessment in COVID-19 vaccine clinical trials to more comprehensively measure immune response.

11 Aug 2022

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

A new study reviews recent advancements made in the development of RSV immunoprophylactic measures.

11 Aug 2022

New evidence explains why thinking hard makes one feel worn out

It's no surprise that hard physical labor wears you out, but what about hard mental labor? Sitting around thinking hard for hours makes one feel worn out, too.

11 Aug 2022

New gel-based cartilage substitute is stronger and more durable than the real thing

Over-the-counter pain relievers, physical therapy, steroid injections -- some people have tried it all and are still dealing with knee pain.

11 Aug 2022

Elevated acetate levels reprogram gut microbiota during alcohol intake

Chronic alcohol use is a major cause of liver damage and death: Approximately 30,000 persons in the United States die annually from alcoholic liver diseases, such as cirrhosis.

11 Aug 2022

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

An analysis of millions of SARS-CoV-2 genomes finds that recombination of the virus is uncommon, but when it occurs, it is most often in the spike protein region, the area which allows the virus to attach to and infect host cells.

11 Aug 2022

Newly designed nanoparticles target the body’s immune cells to turn them against cancer

Scientists of the department of Advanced Organ Bioengineering and Therapeutics (Faculty of S&T, TechMed Centre) recently published a novel cancer immune therapy in the scientific journal Nature Communications.

11 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.

11 Aug 2022

Life Science News

Study paves new way to develop a predictive biomarker for TRAIL therapy

Researchers engineer artificial replicas of G protein-coupled receptors

Three genetic mutations seen in individuals with KCNMA1-linked channelopathy successfully mirrored in mice

In monkeys, spike-based vaccines produce some immunity based on CD8 T-cells

Why is COVID-19 more severe in people older than 50?

Men exposed to industrial air pollution exhibit sperm mitochondrial DNA deletions

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Mount Sinai and Regeneron Genetics Center launch a new human genome sequencing research project

New method for 3D culture accurately quantifies how cancer cells generate forces to spread within tissue

Experts urge FDA to include T cell responses when evaluating COVID vaccines

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

New evidence explains why thinking hard makes one feel worn out

New gel-based cartilage substitute is stronger and more durable than the real thing

Elevated acetate levels reprogram gut microbiota during alcohol intake

Recombination most often occurs on the COVID-19 phylogenetic tree in the form of 'long branches'

Newly designed nanoparticles target the body’s immune cells to turn them against cancer

Novel model reveals how genomic instability arises in histologically benign tissue

Interferon beta reduces binding of three components to RBCs, study finds

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

Extending the reach of Amperia™

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