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Preventable hospital deaths: An interview with Dr Helen Hogan

In 2007/8 when we were thinking about the study, there wasn’t a clear picture of the number of preventable deaths in English hospitals. There had been an important report by the chief medical officer of the NHS in 2000 (An Organisation with a Memory) and he talked of the possibility of between 60,000 and 250,000 cases of severe disability or death arising in hospitals.

18 Jul 2012

Heart-protective protein finally found

It is a cellular component so scarce, some scientists even doubted its existence, and many others gave up searching for its molecular structure. Now a team led by researchers at Johns Hopkins has defined the protein structural composition of mitoKATP, a potassium channel in the mitochondria of the heart and other organs that is known to protect against tissue damage due to a heart attack or stroke.

18 Jul 2012

Rheumatoid arthritis patients and their doctors differ on perception of disease activity

Researchers from Austria have determined that patients with rheumatoid arthritis (RA) and their doctors differ on perception of RA disease activity. The study now available in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR) and published by Wiley, reports that RA patients cite joint pain as the reason for their perception of a change in their disease activity. Rheumatologists, however, stressed joint swelling as the major determinant for their perception of change in RA disease activity.

18 Jul 2012

How does exercise improve heart function in diabetics?

A detailed study of heart muscle function in mice has uncovered evidence to explain why exercise is beneficial for heart function in type 2 diabetes.

18 Jul 2012

Hepatitis C treatment may be helped by vitamin B12 supplements

Adding vitamin B12 to standard hepatitis C virus (HCV) treatment significantly boosts the body’s ability to keep the virus at bay, indicates a pilot study published online in the journal Gut.

18 Jul 2012

Heart defects at birth linked to workplace exposure to solvents

Workplace exposure to organic solvents is linked to several types of heart defects at birth, indicates research published online in Occupational and Environmental Medicine.

18 Jul 2012

Risk of birth defects linked to certain jobs dads do

Several types of job carried out by future fathers may be linked to an increased risk of birth defects in their babies, suggests research published online in Occupational and Environmental Medicine.

18 Jul 2012

Lack of physical activity causes 1 in 10 deaths

A lack of physical activity, or people’s failure to spend 150 minutes a week doing moderate physical activity (eg, brisk walking for 30 minutes, 5 days a week), causes around 6–10% of four major non-communicable diseases (coronary heart disease [CHD], type 2 diabetes, and breast and colon cancer) worldwide, and was responsible for around 5.3 million of the 57 million deaths globally in 2008.

18 Jul 2012

Smoking, hepatitis and liver transplantation: An interview with Dr Peter Ghali

We are very interested in hepatitis C as it is the most common indication for liver transplant in the Western world. The difficulty is that recurrence happens in the majority of patients within the first 2 to 7 years after transplant, and occasionally sooner.

18 Jul 2012

Weighing up the gains for smokers who quit

People seem to gain more weight after giving up smoking than has previously been estimated, report researchers.

17 Jul 2012

Elderly may be undertreated for cardiac disease

Not enough elderly people are being prescribed statins, argue researchers in the BMJ.

17 Jul 2012

Ticagrelor ‘now on equal footing’ with other antiplatelets

The platelet aggregation inhibitor ticagrelor is now considered of equal effectiveness to clopidogrel and prasugrel for patients who have experienced a heart attack or have unstable angina, a report states.

17 Jul 2012

Substance use linked to poor memory, reasoning in BD

The presence of comorbid substance use disorder is associated with significantly poorer visual memory and conceptual reasoning skills in patients with bipolar disorder, US study results show.

17 Jul 2012

Patient autonomy crucial to achieving health goals

Supporting patient autonomy in healthcare leads to positive health outcomes, suggesting that self-determination theories should become the foundation for developing interventions in healthcare promotion, say UK researchers.

17 Jul 2012

Limewater combination therapy can reduce root canal endotoxins

Treating root canals with a combination of chlorhexidine gel and calcium hydroxide results in significant reduction of endotoxins and neutralization of cytotoxic effects compared with the gel plus polymyxin B or saline, report Brazilian researchers.

17 Jul 2012

Hypomagnesemia signals nonrecovery of renal function in AKI

Researchers have identified hypomagnesemia as a risk factor for nonrecovery of renal function among critically ill patients with acute kidney injury.

17 Jul 2012

Arrhythmia finding could enhance COPD management

Arrhythmias could precede exacerbations in chronic obstructive pulmonary disease, raising the possibility of a new target for management and treatment, say researchers.

17 Jul 2012

Mu-opioid receptors put brakes on appetite

Activation of mu-opioid receptors in the nerves of the portal vein walls triggers a gut–brain neural circuit that leads to feelings of satiety, researchers report in Cell.

17 Jul 2012

Computerized mobilization eases chronic neck pain

Computerized mobilization of the cervical spine appears to be a viable treatment option for patients with chronic neck pain, a proof-of-concept trial shows.

17 Jul 2012

Specific therapy may cut pneumonia mortality in HIV babies

The high mortality rate associated with acute severe pneumonia-related respiratory failure in infants exposed to or infected with HIV can be reduced to 30% if a treatment plan involving antibiotics, ventilation, and fluid restriction is used, researchers report.

17 Jul 2012