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Normal p53 gene makes breast cancer chemotherapy with doxorubicin less effective

Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the journal Cancer Cell.

12 Jun 2012

New data on individuals with natural ability to fight off AIDS

"Scientists on Sunday said they had found a key piece in the puzzle as to why a tiny minority of individuals infected with HIV have a natural ability to fight off the deadly AIDS virus," Agence France-Presse reports.

12 Jun 2012

Scientists establish link between autoimmune diseases and nanoparticles

New groundbreaking research by scientists at Trinity College Dublin has found that exposure to nanoparticles can have a serious impact on health, linking it to rheumatoid arthritis and the development of other serious autoimmune diseases.

12 Jun 2012

GlobalPost reports on Cuba's medical outreach to Africa

GlobalPost reports on Cuba's medical outreach to Africa, writing, "A generation ago, Fidel Castro sent Cuban soldiers to intervene in African civil conflicts and fight the Cold War against U.S. proxies. Now, Cuba's doctors are fanning out across the continent as the island expands its role in administering medical services to some of the world's most ailing countries."

12 Jun 2012

Researchers identify two proteins that are required to maintain kidney stem cells

Studying mice and humans, researchers at Washington University School of Medicine in St. Louis and their collaborators in Paris have identified two proteins that are required to maintain a supply of stem cells in the developing kidney.

12 Jun 2012

Researchers find pathway for origin and growth of the most common form of brain and spinal cord tumor – meningioma

Johns Hopkins researchers say they have discovered one of the most important cellular mechanisms driving the growth and progression of meningioma, the most common form of brain and spinal cord tumor.

12 Jun 2012

Main causes of unprofessional behavior among hospitalists revealed

Unprofessional behavior among hospitalists is rare, but those who do behave poorly share common features, according to research published in the Journal of Hospital Medicine.

12 Jun 2012

New campaign urges Americans to get tested for HIV

Greater Than AIDS, a leading national public information response to the domestic epidemic, today unveiled new outdoor media messages urging Americans to get tested for HIV. The “I Got Tested” campaign features real people’s stories of testing and encourages others to “join the movement.”

12 Jun 2012

Sleep apnea may speed-up kidney decline

Patients with chronic kidney disease are commonly exposed to nocturnal hypoxia that may increase the rate of decline in kidney function, Canadian researchers report.

12 Jun 2012

Promising preliminary data for axitinib in metastatic kidney cancer

Preliminary study data show that axitinib may be an effective first-line treatment for metastatic renal cell carcinoma, particularly in patients with high therapeutic drug exposure and a rise in blood pressure during the first 2 weeks of treatment, researchers report.

12 Jun 2012

Risk score may aid emergency heart failure decisions

A novel risk score may help physicians decide whether to admit or discharge patients who present to the emergency department with an acute episode of heart failure, say its developers.

12 Jun 2012

Uncertainty over efficacy of clopidogrel in hemolytic uremic syndrome

Clinical outcomes for children hospitalized with diarrhea-associated hemolytic uremic syndrome are comparable between those treated with clopidogrel and those who are not, show study findings.

12 Jun 2012

Guideline update for infective endocarditis successful

The incidence of infective endocarditis did not increase after American guidelines for antibiotic use before dental procedures were updated in 2007, a report in Circulation shows.

12 Jun 2012

NASA-inspired analysis could anticipate bone loss

Measuring naturally occurring calcium isotopes in urine could indicate whether someone is experiencing bone loss long before traditional imaging methods are able to, say US researchers.

12 Jun 2012

Specific personality traits linked to suicide risk in schizophrenia

Patients with schizophrenia who have a history of suicide attempts show a different pattern of temperament and character traits compared with their nonsuicidal counterparts, say Turkish researchers.

12 Jun 2012

NMDA antibodies increased in mania patients

Patients with bipolar disorder show increased levels of antibodies to the NR2 subunits of the N-methyl-D-aspartate receptor during periods of acute mania, researchers report.

12 Jun 2012

Stress troubles women’s hearts

Women experience more myocardial stress than men, regardless of arterial hemodynamic function and cardiac geometry and output, research shows.

12 Jun 2012

Key dynamics in play in long-awaited health law decision

News outlets report on the key issues and underlying statutes that might shape the Supreme Court's upcoming ruling on the health law, and how stakeholders and politicians are planning their next steps.

12 Jun 2012

DNDi, Astellas partner on new drug discovery research for treatment of NTDs

Astellas Pharma Inc. and the Drugs for Neglected Diseases initiative (DNDi) announced an agreement today to collaborate on drug discovery research for leishmaniasis, Chagas disease, and sleeping sickness - three neglected tropical diseases (NTDs) which together affect nearly 10 million people worldwide.

12 Jun 2012

Organized rallies around U.S. decry contraception coverage mandate

More than 100 organized rallies in states around the nation this weekend decried the Obama administration decision to require insurers and employers to cover contraception in their health plans as an attack on their religious freedom.

12 Jun 2012