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Researchers identify how neural cells build up resistance to opioid pain drugs within hours

Researchers at the University of Montreal's Sainte-Justine Hospital have identified how neural cells are able to build up resistance to opioid pain drugs within hours. "A better understanding of these mechanisms will enable us to design drugs that avoid body resistance to these drugs and produce longer therapeutic responses, including prolonged opioid analgesia", lead author Dr. Graciela Pineyro said.

4 Apr 2012

Norway study raises new U.S. mammogram overdiagnosis questions

An analysis showing significant mammogram overdiagnosis in Norway has raised new questions about mammograms in the U.S., where some say the overdiagnosis problem could be more rampant because of how early most women begin getting them.

4 Apr 2012

First study to evaluate treatment based on molecular profiling of advanced pancreatic cancer

The feasibility of selecting treatment based on individual molecular characteristics was demonstrated in a first-of-its kind pancreatic cancer clinical trial reported today by the Translational Genomics Research Institute (TGen) and the Virginia G. Piper Cancer Center at Scottsdale Healthcare.

4 Apr 2012

Obama confident the health law will be upheld

In his first public comments about the law since last week's Supreme Court oral arguments, President Barack Obama not only defended the measure and maintained confidence that it would not be overturned, but he also offered warnings against judicial activism.

4 Apr 2012

Tai Chi improves cardiovascular function and body strength in older adults

Exercise which can achieve both cardiovascular function and muscle strength "would be a preferred mode of training for older persons", say investigators.

4 Apr 2012

IPS examines efforts to end FGM in Liberia

Inter Press Service examines efforts to end female genital mutilation (FGM) in Liberia. "Through cooperative efforts with traditional leaders, the government of Liberia is quietly moving to ... bring an end to female genital cutting in Liberia," IPS writes.

4 Apr 2012

Multimarker molecular stool test for colon cancer unaffected by medication, lifestyle factors

Research on an investigational DNA methylation test for colorectal cancer demonstrated that the only clinical variable that influenced test results was age, according to results presented at the AACR Annual Meeting 2012, held here March 31 - April 4.

4 Apr 2012

Health law action at the high court takes a political toll

Findings from a new poll indicate that the public felt less favorable about both the health law and the Supreme Court after last week's oral arguments.

4 Apr 2012

Combination treatment shows promise against NSCLC patients ineligible for bevacizumab

A combination of nab-paclitaxel and carboplatin for the treatment of non-small cell lung cancer may be a promising option for patients ineligible for treatment with bevacizumab, according to data presented at the AACR Annual Meeting 2012, held here March 31 - April 4.

4 Apr 2012

New County Health Rankings released

Researchers found distinct regional patterns: They reported that excessive drinking rates were highest in the Northern states, while rates of teen births, sexually transmitted infections and children in poverty were highest in the South.

4 Apr 2012

Positive preclinical results from Cancer Therapeutics' CTX-0294945 plus Avastin study

Cancer Therapeutics, a company focused on translating cancer biology research into novel treatments for cancer, today announced positive preclinical results for CTX-0294945 as an adjuvant therapy to the cancer drug Avastin (bevacizumab - Genentech/Roche). The data is presented today in a late breaking poster at the American Association for Cancer Research (AACR) Annual Meeting 2012 in Chicago, USA.

4 Apr 2012

Improved access to family planning in Africa will lead to economic development

Melinda Gates of the Bill & Melinda Gates Foundation writes in an opinion piece in Nigeria's Vanguard, "My top priority as a co-chair of the foundation I run with my husband is making sure that all families have access to safe and effective contraception tools that empower them to make a decision about what's best for them and their family. And that means encouraging aid donors and governments here in Nigeria and across Africa to make family planning a priority."

4 Apr 2012

NIDA to showcase PEERx teen initiative at National RX Drug Abuse Summit

A unique, new campaign targeting teens will be on exhibit at the first national summit addressing the prescription drug abuse epidemic. The National Institute on Drug Abuse (NIDA) will showcase "PEERx," a NIDA initiative that uses interactive videos and other tools to educate teens about the dangers of prescription drug abuse and help them to spread the word.

4 Apr 2012

Advocates for Youth report examines youth policies within PEPFAR

A new report from Advocates for Youth "analyzes youth policies within the President's Emergency Plan for AIDS Relief (PEPFAR), including its legislative authority, most recent five-year strategy, relevant guidance documents, and all 21 currently available PEPFAR country Partnership Frameworks."

4 Apr 2012

Scientists discover why rapamycin causes diabetic-like symptoms in patients

Scientists at Dana-Farber Cancer Institute have discovered why diabetic-like symptoms develop in some patients given rapamycin, an immune-suppressant drug that also has shown anti-cancer activity and may even slow ageing.

4 Apr 2012

Oral arguments showcased justices' personalities

The New York Times reports that last week's action at the Supreme Court gave the public an in-depth view of the insitution and the justices. Meanwhile, the Associated Press reports that, in a recent speech, Justice Sonia Sotomayor didn't give any hints about what the high court will do on the health law question.

4 Apr 2012

Two leading authorities partner to write and edit Stroke Prevention, Treatment and Rehabilitation

Stroke prevention, treatment and rehabilitation have come a long way in the time since Neurologist Dr. David Spence of Western University began treating patients. "My first day on call, I was paged to the emergency department for a patient with a stroke. When I answered the page, from the cafeteria, I was told to go ahead and finish my dinner. There was nothing that could be done for him."

4 Apr 2012

Ryan budget plan draws tough talk from Obama while insurers keep their distance

President Barack Obama offers sharp critcism of the GOP budget plan, which passed the House on a near-party-line vote last week and which has been embraced by GOP presidential hopefuls. Although the plan, written by House Budget Chairman Paul Ryan, R-Wisc., would greatly expand the role of private insurers in Medicare, the insurance industry has been mostly silent as well.

4 Apr 2012

Nuvilex realizes important role for Cell-in-a-Box technology

Nuvilex, Inc., an emerging biotechnology provider of cell and gene therapy solutions through acquisition of SG Austria assets, realizes the important role for Cell-in-a-Box technology and aims to bring to light its use in the production of therapeutic antibodies for clinically important diseases.

4 Apr 2012

White House, FDA often experience internal clashes

The internal clashes over F.D.A. policy played out against a broader backdrop of regulatory politics. Republicans have made the charge that Mr. Obama is an overzealous and job-killing regulator - a central element of their case against his re-election. And on issues from clean air to investor protections, the White House has been carefully calibrating its election season positions.

4 Apr 2012