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Tumor-targeted immune cells cure prostate cancer without causing systemic immune suppression

In a major breakthrough in cancer gene therapy, a Northwestern University researcher has endowed immune cells with the ability to specifically target metastatic prostate cancer in mice without causing the toxic immune suppression that has been associated with earlier forms of cancer gene therapy.

14 Mar 2005

Researchers identify biochemical target that could lead to a new class of antibiotics to fight TB

A worldwide health problem, tuberculosis kills more people than any other bacterial infection. The World Health Organization estimates that two billion people are infected with TB, and that two million people die each year from the disease.

14 Mar 2005

Research shows how bacteria respond when subjected to environmental alterations in space stations

An article in Journal of Applied Microbiology investigates how bacteria respond when they are subjected to environmental alterations, such as those of space stations, which feature lowered effects of gravity.

14 Mar 2005

Naturally occurring antifungal agent in saliva kills oral pathogen responsible for most HIV-related oral infections

Oral biologists at the University at Buffalo have shown for the first time how histatin, the naturally occurring antifungal agent in saliva, kills the oral pathogen Candida albicans, the fungus responsible for most HIV-related oral infections.

14 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005

Yoghurt reduces bad breath

Eating traditional yoghurt reduces the bacteria that cause bad breath.

14 Mar 2005

Health consequences of lip piercing

Numerous case reports and a few clinical studies have examined the association between tongue piercing and receding gums, and oral piercing, typically involving the tongue and/or the lip, has been associated with periodontal complications. However, there are no such studies on lip piercing.

14 Mar 2005

Research could lead to new drugs that combat HIV infection by shutting down the virus's assembly lines

After infecting a susceptible cell, the human immunodeficiency virus hijacks that cell's normal machinery to produce carbon copies of itself. New HIV particles roll off the cellular assembly lines, burst like bubbles out of the cell, and float off to invade other cellular factories.

14 Mar 2005

Weight status of children ages 8 to 15 predicts obesity and high blood pressure in adulthood

New research shows that children between 8 and 15 years old who are in the upper half of the normal weight range are more likely than their leaner peers to become obese or overweight as young adults.

14 Mar 2005

DNA weak links may provide clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

13 Mar 2005

New way of looking at MicroRNA and how it controls gene expression

A group of scientists at The Scripps Research Institute is reporting a discovery that sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock.

13 Mar 2005

Alcohol intervention attempted for violent males

Serious facial and dental injuries often go hand-in-hand with heavy alcohol consumption and violent behavior, especially by teenage boys and young men.

13 Mar 2005

RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease.

13 Mar 2005