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Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

15 Feb 2023

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

Patients with resectable non-small cell lung cancer (NSCLC) who were treated with neoadjuvant nivolumab had improved five-year recurrence-free and overall survival rates compared with historical outcomes.

15 Feb 2023

Study highlights increased risks for young pregnant adolescents compared with older teens, adults

Young adolescents face different challenges in pregnancy compared with their older teenage peers and adults that are sometimes exacerbated by high rates of obesity, a new study by UT Southwestern researchers suggests.

15 Feb 2023

Sleep irregularity may increase the risk for atherosclerosis

Sleep irregularity - chronically disrupted sleep and highly variable sleep durations night after night - may increase the risk for atherosclerosis, according to a study led by Kelsie Full, PhD, MPH, of Vanderbilt University Medical Center.

15 Feb 2023

Increasing numbers of cancer survivors at high risk for cardiovascular disease

American Cancer Society (ACS) research estimates there are more than 18 million adult survivors of cancer in the United States, and that number is expected to climb to more than 22 million by 2030.

15 Feb 2023

Migraine drug could be a potential treatment for acute kidney injury

The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.

15 Feb 2023

Computational modeling helps uncover genomic mutations that likely influenced human cognition

Researchers from the National Institutes of Health (NIH) used computational modeling to uncover mutations in the human genome that likely influenced the evolution of human cognition.

15 Feb 2023

Three new language versions of the 'Together by St. Jude' online resource launched

St. Jude Children's Research Hospital today announced the launch of three new language versions of the Together by St. Jude online resource, a free source of information and education for families facing childhood and adolescent cancer.

15 Feb 2023

Irregular sleeping habits linked to atherosclerosis risk in older adults

Sleeping an inconsistent number of hours each night and falling asleep at different times may increase the risk of developing atherosclerosis among adults older than 45 compared to people with more consistent sleep habits, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

15 Feb 2023

Novel predictive index for gastric cancer prognosis

A new research paper was published in Oncotarget's Volume 14 on January 31, 2023, entitled, "Novel inflammation-combined prognostic index to predict survival outcomes in patients with gastric cancer."

15 Feb 2023

"AutoPLP" technique enables rapid, accurate detection of mutating bacteria and viruses

As we now know from our experience with the COVID-19 pandemic, the microbes responsible for some infections can rapidly mutate into variants that evade detection and treatment.

15 Feb 2023

Nusinersen treatment improves spinal muscular atrophy patients’ walking distance

A positive effect of nusinersen treatment on motor function in ambulant pediatric and adult spinal muscular atrophy (SMA) patients during a 38-month period has been demonstrated by an analysis of data from the SMArtCARE registry.

15 Feb 2023

Higher intake of free sugars linked with increased risk of cardiovascular disease

Higher intake of free sugars – added sugars and those naturally present in honey and fruit juice – is associated with a higher risk of cardiovascular disease, reports a study published in BMC Medicine.

15 Feb 2023

Scientific breakthrough by Sjöberg laureate brings new hope to lung cancer patients

This year's Sjöberg Prize in cancer research of one million dollars is awarded to professor Kevan Shokat, University of California, USA.

15 Feb 2023

Promising HIV vaccine candidate by Texas Biomed stops the virus upon entry

The National Institutes of Health has awarded $3.8 million to Texas Biomedical Research Institute to further develop a promising HIV vaccine candidate that stops the virus upon entry, before it begins rapidly spreading throughout the body.

15 Feb 2023

Study: Organ damage persists in 59% of COVID patients a year after initial symptoms

A new comprehensive study of organ impairment in long COVID patients over twelve months shows organ damage persisted in 59% of patients a year after initial symptoms, even in those not severely affected when first diagnosed with the virus.

15 Feb 2023

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

Researchers investigated the tolerability and safety of a microbiome therapy called SER-109 to treat recurrent infections of Clostridioides difficile in adults.

15 Feb 2023

How does previous diet impact the endocannabinoidome and microbiome response to a short-term Mediterranean diet intervention?

Researchers assessed the different impacts of diet on the gut microbiome.

15 Feb 2023

Rapid clinical test predicts which people with neck pain may benefit from epidural steroid injections

Researchers from Johns Hopkins Medicine and several other institutions say they have developed a quick clinical test that predicts which people with neck pain are more likely to benefit from epidural steroid injections, which deliver drugs directly around the spinal nerves to stop nerve inflammation and reduce pain.

15 Feb 2023

Aircraft noise exposure before MI amplifies subsequent cardiovascular inflammation

Traffic noise may play an essential role in the development and deterioration of ischemic heart disease. Researchers from the Cardiology Department at the University Medical Center Mainz now discovered that noise exposure(average sound pressure level 72 dB; peak level 85 dB) up to 4d resulted in pro-inflammatory aortic gene expression in mice.

15 Feb 2023

Medical News

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

Neoadjuvant nivolumab treatment improves survival rates in NSCLC patients

Study highlights increased risks for young pregnant adolescents compared with older teens, adults

Sleep irregularity may increase the risk for atherosclerosis

Increasing numbers of cancer survivors at high risk for cardiovascular disease

Migraine drug could be a potential treatment for acute kidney injury

Computational modeling helps uncover genomic mutations that likely influenced human cognition

Three new language versions of the 'Together by St. Jude' online resource launched

Irregular sleeping habits linked to atherosclerosis risk in older adults

Novel predictive index for gastric cancer prognosis

"AutoPLP" technique enables rapid, accurate detection of mutating bacteria and viruses

Nusinersen treatment improves spinal muscular atrophy patients’ walking distance

Higher intake of free sugars linked with increased risk of cardiovascular disease

Scientific breakthrough by Sjöberg laureate brings new hope to lung cancer patients

Promising HIV vaccine candidate by Texas Biomed stops the virus upon entry

Study: Organ damage persists in 59% of COVID patients a year after initial symptoms

What is the tolerability profile and rate of recurrent CDI after administrating microbiome therapeutic SER-109 post-antibiotic treatment?

How does previous diet impact the endocannabinoidome and microbiome response to a short-term Mediterranean diet intervention?

Rapid clinical test predicts which people with neck pain may benefit from epidural steroid injections

Aircraft noise exposure before MI amplifies subsequent cardiovascular inflammation

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

AI-powered analytics and experimental validation

Membrane proteins in focus: Turning high-risk targets into routine workflows

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