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Canadian scientist discusses about how society could better prepare for future pandemics

Aled Edwards is of two minds about medicine's response to COVID-19. On one hand, he notes, we had life-saving vaccines and therapies less than a year after the discovery of SARS-CoV-2. On the other, more than six million, and possibly as many as 18 million people have died, and global access to advances that can prevent and treat severe disease remains highly inequitable.

11 Mar 2022

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Tiny structures called nanoparticles can be used to carry substances to certain parts of the body - for example, to deliver a chemotherapy drug to a tumor.

11 Mar 2022

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

People who gained immunity - either through vaccination or exposure - against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen's omicron variant.

11 Mar 2022

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

Researchers investigated the effects of SARS-CoV-2 spike mutations on antiviral restriction mediated by interferon-induced transmembrane proteins and guanylate binding proteins.

11 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

A recent systematic review and meta-analysis evaluated the safety and efficacy of intensified anticoagulation therapy in COVID-19 patients.

11 Mar 2022

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

A recent study assessed the safety and immunogenicity of mRNA-1273 booster vaccine against COVID-19.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Researchers assessed the increase in Pfizer/BioNTech BNT162b2 vaccine efficacy on administering a homologous booster dose.

11 Mar 2022

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Researchers evaluated the immune responses after boosting with Pfizer's BNT162b2 vaccine.

11 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Researchers observed that Golgi fragmentation induced by SARS-CoV-2 facilitates viral trafficking.

11 Mar 2022

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Researchers elucidated antiviral activities of aminoglycoside geneticin against seven SARS-CoV-2 variants using different cell lines and respiratory tissues.

11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers defined a novel polynucleotide-based Distinctiveness metric to capture the proteome-level differences of emerging SARS-CoV-2 variants and lineages against all previously identified ones.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Study finds greater financial worries and lower rates of psychological distress among immigrants

Compared to US-born individuals, immigrants to the United States have increased financial worries – especially related to things like retirement and medical costs, reports a study in the March issue of the Journal of Psychiatric Practice.

11 Mar 2022

Child–mother attachment in toddlerhood moderates adolescents’ evaluation of trustworthiness

Interpersonal trust is a crucial component of healthy relationships. When we interact with strangers, we quickly gauge whether we can trust them. And those important social skills may be shaped by our earliest relationship with caregivers.

11 Mar 2022

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer.

10 Mar 2022

Multi-institutional teams awarded grant support from the Starr Cancer Consortium

Two multi-institutional teams led by Weill Cornell Medicine scientists have been awarded grant support from the Starr Cancer Consortium. Both grants will fund work applying new technologies to develop more detailed knowledge of tumor biology, with one team focusing on Hodgkin lymphoma and the other on the purity of tumor samples on pathology slides.

10 Mar 2022

Medical News

Canadian scientist discusses about how society could better prepare for future pandemics

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Study shows the mutations leading to omicron variant did not help virus escape recognition by T cells

Exploring SARS-CoV-2 spike evolution in relation to sensitivity to antiviral restriction factors

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients

Study indicates a 100 µg mRNA-1273 booster has acceptable safety and robust antibody response against SARS-CoV-2

Novel genetic relationships with severe SARS-CoV-2

Updated results from ongoing study on the effect of a BNT162b2 booster dose on anti-SARS-CoV-2 antibodies

Study suggests increased durability of immune responses towards SARS-CoV-2 spike protein after BNT62b2 booster

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Study shows SARS-CoV-2 infection induces global alterations of the host endomembrane system

Aminoglycoside antibiotic geneticin shows selective antiviral effect against SARS-CoV-2

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Study shows competitive fitness of emerging SARS-CoV-2 variants linked to their distinctiveness relative to identified lineages

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Study finds greater financial worries and lower rates of psychological distress among immigrants

Child–mother attachment in toddlerhood moderates adolescents’ evaluation of trustworthiness

Ribociclib plus endocrine therapy offers survival benefit for postmenopausal patients with metastatic breast cancer

Multi-institutional teams awarded grant support from the Starr Cancer Consortium

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