Study: Perineuronal nets are responsible for long-term stability of mental maps

A reliable sense of space is essential for daily life and memory formation. Removing sugar-coated proteins around neurons in the brains' internal gps makes the mental map of space unstable, shows in a study published in the journal Nature communications.

Scientists from the University of Oslo, Norway have shown that the sugar-coated extracellular matrix proteins, called perineuronal nets, that wrap densely around neurons in the brain, are responsible for the long-term stability of the mental maps. This study is the first to link extracellular matrix to the stability of our sense of space.

Every time you revisit a place, neurons will be reactivated in the exact same place telling you where you are.

When we removed the perineuronal nets from neurons in the entorhinal cortex in rats, we observed that new grid maps formed more slowly in novel environments compared to grid cells from rats that had intact perineuronal nets. Even more surprising was that when the rats returned to their familiar arenas, also the stored grid maps had become unstable. This suggests that the perineuronal nets contribute to maintain the integrity of stored mental maps and prevent them from being overwritten by new experiences."

Charlotte Christensen, Study Main Author, University of Oslo

They found that not only was the grid map unstable, also the precise timing between grid cell firing was impaired after removal of the perineuronal nets. This opens for future investigations to elucidate if the confusion with time or place in Alzheimer's patients is associated with changes in the extracellular matrix of the brain.

Journal reference:

Christensen, A. C., et al. (2021) Perineuronal nets stabilize the grid cell network. Nature Communications.


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