Molecular & Structural Biology

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Breakthrough platform reveals the choreography of mammalian transcription

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

27 Nov 2025

Researchers capture a ribozyme in motion for the first time

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

27 Nov 2025

Kinase inhibitors can accelerate the degradation of target proteins, study reveals

Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins.

26 Nov 2025

New sequencing method reveals how transposons move and shape the genome

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome.

22 Nov 2025

New neuron signaling mechanism reveals safer pathway for pain treatment

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead to safer, more effective treatments.

20 Nov 2025

Cryo-EM reveals how proteins are protected during synthesis

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most important steps in the process of building proteins is glycosylation, when sugar molecules (glycans) are attached to the maturing protein.

19 Nov 2025

Primerdesign launches exsig Mag RapidBead Pro Extraction kit for DNA and RNA

Primerdesign (part of the Novacyt Group), a company focused on the design, manufacture, validation and supply of real-time PCR kits and reagents, today announced the launch of its exsig® Mag RapidBead Pro Extraction kit.

19 Nov 2025

Breast cancer cells use a molecular switch to survive stress

Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust their gene expression to protect themselves.

17 Nov 2025

New symposium empowers early career scientists in stem cell and developmental biology

For the first time, the International Society for Stem Cell Research (ISSCR), the Society for Developmental Biology (SDB), and the Allen Institute are collaborating to present a three-day scientific symposium led by early-career scientists.

13 Nov 2025

Cornell team unveils high-resolution tool for tracking kinase activity

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – enzymes that control nearly all cellular processes – turn on and off inside living cells.

13 Nov 2025

Carolina Molecular partners with Pixelgen, becomes first US certified service provider for Pixelgen Proxiome Kit - Pixelgen Technologies

Carolina Molecular Inc., a leading molecular testing services laboratory, and Pixelgen Technologies AB announced today a partnership to expand access to cutting-edge 3D protein interactomics capabilities to researchers and clinicians in the United States. Carolina Molecular will be the first certified U.S. service provider for Pixelgen.

13 Nov 2025

Scientists map kinesin-2 tail structure to understand cargo binding

For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo remained a mystery. The new study provides a key piece of this puzzle by revealing the atomic-level structure of the kinesin-2 tail and its interaction with cargo and adaptor proteins.

6 Nov 2025

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Urolithin A, a natural postbiotic known to trigger mitophagy, rejuvenated key immune cell functions in healthy middle-aged adults after 28 days. The trial showed a shift toward a youthful, energy-efficient CD8⁺ T-cell profile and enhanced bacterial clearance without inflammatory side effects.

3 Nov 2025

Scientists capture a near-continuous molecular movie of ribosome formation

Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs to live. But as far as how ribosomes themselves were formed, tantalizingly little was known.

30 Oct 2025

Two microbial metabolites compete to control the cells' protein building machinery

The microbiome-the trillions of bacteria, viruses, and fungi that live quietly in our body-plays a crucial role in shaping human health by providing a variety of micronutrients necessary for vital functions.

30 Oct 2025

Unlocking the secrets of NMDA receptors for better brain health

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell-and the molecular gatekeepers that help control them.

29 Oct 2025

Novel 3D chromosome mapping method can reliably reveal hidden structural variants

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new discoveries.

29 Oct 2025

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

27 Oct 2025

Qureight Vascul8 model for pulmonary vascular disorders validated in peer-reviewed study, offering potential to improve treatment options and patient outcomes following surgery

Qureight, a techbio company advancing the understanding of lung and heart disease through application of its AI-powered imaging and clinical data curation platform, today announced the publication of a peer-reviewed study validating its Vascul8™ model for pulmonary vascular disorders, in the American Journal of Respiratory Cell and Molecular Biology.

27 Oct 2025

New insight into TRPM3 heat sensor reveals how the body detects temperature

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained an elusive mystery.

24 Oct 2025

Molecular & Structural Biology

Breakthrough platform reveals the choreography of mammalian transcription

Researchers capture a ribozyme in motion for the first time

Kinase inhibitors can accelerate the degradation of target proteins, study reveals

New sequencing method reveals how transposons move and shape the genome

New neuron signaling mechanism reveals safer pathway for pain treatment

Cryo-EM reveals how proteins are protected during synthesis

Primerdesign launches exsig Mag RapidBead Pro Extraction kit for DNA and RNA

Breast cancer cells use a molecular switch to survive stress

New symposium empowers early career scientists in stem cell and developmental biology

Cornell team unveils high-resolution tool for tracking kinase activity

Carolina Molecular partners with Pixelgen, becomes first US certified service provider for Pixelgen Proxiome Kit - Pixelgen Technologies

Scientists map kinesin-2 tail structure to understand cargo binding

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Scientists capture a near-continuous molecular movie of ribosome formation

Two microbial metabolites compete to control the cells' protein building machinery

Unlocking the secrets of NMDA receptors for better brain health

Novel 3D chromosome mapping method can reliably reveal hidden structural variants

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Qureight Vascul8 model for pulmonary vascular disorders validated in peer-reviewed study, offering potential to improve treatment options and patient outcomes following surgery

New insight into TRPM3 heat sensor reveals how the body detects temperature

Extending the reach of Amperia™

Modular cleanrooms: Enhancing flexibility and compliance

Redefining control and consistency in anaerobic microbiome workflows

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