Molecular & Structural Biology

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Novel 3D chromosome mapping method can reliably reveal hidden structural variants

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new discoveries.

29 Oct 2025

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR).

27 Oct 2025

Qureight Vascul8 model for pulmonary vascular disorders validated in peer-reviewed study, offering potential to improve treatment options and patient outcomes following surgery

Qureight, a techbio company advancing the understanding of lung and heart disease through application of its AI-powered imaging and clinical data curation platform, today announced the publication of a peer-reviewed study validating its Vascul8™ model for pulmonary vascular disorders, in the American Journal of Respiratory Cell and Molecular Biology.

27 Oct 2025

New insight into TRPM3 heat sensor reveals how the body detects temperature

The ability to sense heat protects the body from burns and injury. But how the body actually feels temperature has remained an elusive mystery.

24 Oct 2025

Study unravels the genetic shield against winter vomiting disease

Winter vomiting disease is caused by the Norovirus, which is most virulent during the colder half of the year.

24 Oct 2025

Researchers map the complex sugar chains attached to rat serum proteins

A comprehensive study mapped the dynamic glycosylation landscape of rat serum proteins, uncovering sex- and time-dependent variations with clear cell-type specificity.

24 Oct 2025

Molecular evidence connects higher childhood cognitive function to longer lifespan

Researchers led by Dr. W. David Hill at the University of Edinburgh have identified a significant genetic correlation between childhood cognitive function and longevity, providing the first molecular genetic evidence that intelligence measured in youth shares genetic factors with lifespan.

21 Oct 2025

New insights reveal persistent genome structure during cell division

Before cells can divide, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material.

17 Oct 2025

Study uncovers mechanisms regulating the cell’s primary cilia

Prof. Dr. Elif Nur Fırat Karalar from Koç University's Department of Molecular Biology and Genetics and her team have uncovered the molecular mechanisms responsible for regulating a structure that plays a critical role in how cells communicate with their environment.

16 Oct 2025

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's Research Hospital.

15 Oct 2025

Ribosomal RNA found to share unique motifs with nervous system genes

Ribosomal RNA (rRNA) is a type of molecule and a key building block of the ribosome, the cell's protein-making machinery. rRNA accounts for much of the RNA in a cell, and it's crucial for life.

14 Oct 2025

Evolutionary mutation in cGAS enhances naked mole-rat DNA repair

The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an enzyme in the innate immune system that senses DNA to trigger immune responses – may enhance the animal's ability to repair aging-related genetic damage, whereas in other species, such as mice and humans, cGAS can suppress DNA repair.

10 Oct 2025

UCLA scientists uncover the role of DGRs in structuring the infant gut microbiome

Everywhere you go, you carry a population of microbes in your gastrointestinal tract that outnumber the human cells making up your body.

10 Oct 2025

Research uncovers ASPL's critical role in stress granule life cycle

Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked to neurodegenerative diseases.

9 Oct 2025

New computer-driven method helps understand how membrane proteins work at the atomic level

Cellular membrane proteins play many important roles throughout the body, including transporting substances in and out of the cell, transmitting signals, speeding up reactions and helping neighboring cells stick together.

7 Oct 2025

Wasatch Biolabs expands service portfolio with Oxford Nanopore assays in Pharmacogenomics, Telomere Sequencing, and mRNA Vaccine Quality Control

Wasatch BioLabs (WBL), a Renew Biotechnologies subsidiary, and the largest U.S. sequencing service provider dedicated exclusively to long-read sequencing, today announced the addition of three Oxford Nanopore-developed research-use-only (RUO) assays to its service portfolio: a Pharmacogenomics (PgX) panel, Telomere Sequencing, and mRNA Vaccine Quality Control.

7 Oct 2025

Researchers design intrinsically disordered proteins with tailored properties

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using computers to accurately predict the 3D structure of any given amino acid sequence.

7 Oct 2025

AI-designed proteins revolutionize gene editing precision and safety

Researchers at Integra Therapeutics, in collaboration with the Pompeu Fabra University (UPF) Department of Medicine and Life Sciences (MELIS) and the Center for Genomic Regulation (CRG), have designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature.

6 Oct 2025

New NMR technique reveals atomic-scale motion in catalytic enzyme function

Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex molecular machinery like enzymes move while they help catalyze reactions.

6 Oct 2025

Tiny DNA junctions provide feedback to control genetic crossovers

Every new life begins after a genetic shuffle. When organisms make eggs or sperm, maternal and paternal chromosomes pair up and swap pieces of DNA in a process called crossing over.

25 Sep 2025

Molecular & Structural Biology

Novel 3D chromosome mapping method can reliably reveal hidden structural variants

New study reveals how the glucocorticoid receptor forms complex structures inside cells

Qureight Vascul8 model for pulmonary vascular disorders validated in peer-reviewed study, offering potential to improve treatment options and patient outcomes following surgery

New insight into TRPM3 heat sensor reveals how the body detects temperature

Study unravels the genetic shield against winter vomiting disease

Researchers map the complex sugar chains attached to rat serum proteins

Molecular evidence connects higher childhood cognitive function to longer lifespan

New insights reveal persistent genome structure during cell division

Study uncovers mechanisms regulating the cell’s primary cilia

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

Ribosomal RNA found to share unique motifs with nervous system genes

Evolutionary mutation in cGAS enhances naked mole-rat DNA repair

UCLA scientists uncover the role of DGRs in structuring the infant gut microbiome

Research uncovers ASPL's critical role in stress granule life cycle

New computer-driven method helps understand how membrane proteins work at the atomic level

Wasatch Biolabs expands service portfolio with Oxford Nanopore assays in Pharmacogenomics, Telomere Sequencing, and mRNA Vaccine Quality Control

Researchers design intrinsically disordered proteins with tailored properties

AI-designed proteins revolutionize gene editing precision and safety

New NMR technique reveals atomic-scale motion in catalytic enzyme function

Tiny DNA junctions provide feedback to control genetic crossovers

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

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