Cell Biology

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UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Researchers at the University of Virginia School of Medicine have overturned conventional wisdom on the workings of vital hormone receptors within cells, a finding that could boost drug development for diabetes and related metabolic disorders, cancer and other diseases.

31 Jul 2021

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

The mutations that give rise to melanoma result from a chemical conversion in DNA fueled by sunlight -; not just a DNA copying error as previously believed, reports a study by Van Andel Institute scientists published today in Science Advances.

30 Jul 2021

Researchers develop two complementary bladder models to study UTIs

Urinary tract infections (UTIs) are among the most common bacterial infections. They usually require treatment with antibiotics, and almost a quarter of treated cases lead to recurrent infection.

30 Jul 2021

Study provides new understanding on function of mitofusin 2 in cellular energy metabolism

Mitofusin 2 is a key protein in the regulation of the physiology of mitochondria ─cellular organelles that produce energy─ involved in several neurodegenerative and cardiovascular diseases, as well as in cancer.

30 Jul 2021

New study shines light on how plant cells perceive and respond to mechanical forces

Minuscule tunnels through the cell membrane help cells to perceive and respond to mechanical forces, such as pressure or touch. A new study in the journal Science is among the first to directly investigate what one type of these mechanosensitive ion channels is doing in the tip-growing cells in moss and pollen tubes of flowering plants, and how.

29 Jul 2021

Study examines the role of programmed cell death ligands in skin immune responses

T cells are a crucial part of the human adaptive immune system. In response to a foreign invader in the body, various subsets of T cells are responsible for several functions that include killing infected cells and secreting signaling molecules called cytokines that tell other immune cells where to go and what to do.

29 Jul 2021

Antibacterial immunity may change in the intestines based on circadian cycle

The body's ability to prevent food poisoning by producing a natural antimicrobial compound increases during the day, when exposure to noxious bacteria is most likely, a new study by UT Southwestern scientists suggests.

28 Jul 2021

Cats could be a valuable model organism for geneticists, expert says

Although cats have lived alongside humans for millennia, it remains a dogs' world. This bias has historically bled into science as well.

28 Jul 2021

Researchers create detailed molecular atlas of fetal development of the brain

Researchers at Karolinska Institutet in Sweden have developed a detailed molecular atlas of the fetal development of the brain.

28 Jul 2021

Non-invasive imaging method can predict the efficiency of cardiomyocyte differentiation

Stem cell research holds great potential for regenerative therapies and treatments to combat cardiovascular disease, which is responsible for over 30% of all deaths worldwide.

28 Jul 2021

Study: All GA-binding proteins have the highest expression levels in secondary glioblastomas

Oncotarget published "TERT and its binding protein: overexpression of GABPA/B in high grade gliomas" which reported that all GA-binding proteins progress through the glioma grades and have the highest expression levels in secondary glioblastomas.

28 Jul 2021

New insights on replication-stress sensitivity in breast cancer cells

Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1.

28 Jul 2021

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

Oncotarget published "Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells" which reported that retinoic acid is a fundamental regulator of cell cycle and cell differentiation.

28 Jul 2021

T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals

New research conducted in monkeys reveals that T cells are not critical for the recovery of primates from acute COVID-19 infections.

27 Jul 2021

Umbilical cord-derived mesenchymal stem cells show promise to treat muscular dystrophies

Results of a compassionate-use study released in STEM CELLS Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ), a substance found in the umbilical cord. Led by doctors at Klara Medical Center (KMC), Czestochowa, Poland, these WJ-MSC treatments resulted in significant improvement in several body muscles in most of the patients, with no serious side effects.

27 Jul 2021

Research provides insights into how the hippocampus contributes to memory storage in the cortex

A new MIT study of how a mammalian brain remembers what it sees shows that while individual images are stored in the visual cortex, the ability to recognize a sequence of sights critically depends on guidance from the hippocampus, a deeper structure strongly associated with memory but shrouded in mystery about exactly how.

27 Jul 2021

Analysis of DNA tags could advance the understanding and treatment of many cancers

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

27 Jul 2021

Simple method to assess the risk of vascular inflammation for diabetes patients

A team of international scientists from Nanyang Technological University, Singapore (NTU Singapore), Tan Tock Seng Hospital (TTSH) in Singapore, and the Massachusetts Institute of Technology (MIT) has developed a simple method of extracting tiny biological particles from a person's blood and use them as biomarkers to assess the health of their blood vessels.

27 Jul 2021

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

Researchers from the Institute of Process Engineering of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy.

26 Jul 2021

Breakthrough treatment could improve the immune system's ability to destroy cancer cells

New research has identified potential treatment that could improve the human immune system's ability to search out and destroy cancer cells within the body.

26 Jul 2021

Cell Biology

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Melanoma mutations result from a chemical conversion in DNA fueled by sunlight, study reports

Researchers develop two complementary bladder models to study UTIs

Study provides new understanding on function of mitofusin 2 in cellular energy metabolism

New study shines light on how plant cells perceive and respond to mechanical forces

Study examines the role of programmed cell death ligands in skin immune responses

Antibacterial immunity may change in the intestines based on circadian cycle

Cats could be a valuable model organism for geneticists, expert says

Researchers create detailed molecular atlas of fetal development of the brain

Non-invasive imaging method can predict the efficiency of cardiomyocyte differentiation

Study: All GA-binding proteins have the highest expression levels in secondary glioblastomas

New insights on replication-stress sensitivity in breast cancer cells

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

T cells are not critical for recovery of primates from acute COVID-19 infections, study reveals

Umbilical cord-derived mesenchymal stem cells show promise to treat muscular dystrophies

Research provides insights into how the hippocampus contributes to memory storage in the cortex

Analysis of DNA tags could advance the understanding and treatment of many cancers

Simple method to assess the risk of vascular inflammation for diabetes patients

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

Breakthrough treatment could improve the immune system's ability to destroy cancer cells

Increasing your risk of IBD through processed food

World Brain Day 2021: An interview with Professor Alan Thompson

Preventing lethal blood clots

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