Cell Biology

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INTEGRA Biosciences and Parse Biosciences offer affordable, automated single cell RNA sequencing

INTEGRA Biosciences and Parse Biosciences have partnered to automate single cell RNA sequencing (scRNA-seq) on the ASSIST PLUS pipetting robot.

From INTEGRA Biosciences 26 Jul 2024

Electrical currents could supercharge cancer-killing immune cells, study finds

Scientists have discovered that electrical currents may make Natural Killer (NK) cells – our very own cancer-killing immune cells – even better killers, which could have significant implications for treating some cancers.

25 Jul 2024

Stanford's muscle chips reveal microgravity's impact on muscle regeneration

A gentle rumble ran under Ngan Huang's feet as a rocket carrying her research-;live, human muscle cells grown on scaffolds fixed on tiny chips-;lifted off, climbed, and disappeared into the sky to the International Space Station National Laboratory.

25 Jul 2024

Study highlights infection as major post-CAR-T therapy challenge

In patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL), the two hallmark post-chimeric antigen receptor (CAR)-T therapy toxicities are extremely rare after two weeks, supporting a shorter, more flexible toxicity monitoring period, according to a study published in Blood Advances.

25 Jul 2024

Unprecedented brain cell mapping sheds light on Alzheimer's

Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting.

25 Jul 2024

New insights into p16 protein could lead to advances in cancer diagnosis and treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of various cancers.

25 Jul 2024

Cryo-electron microscopy reveals how membrane microdomains respond to mechanical stress

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood.

24 Jul 2024

Multiplexed STED nanoscopy technique reduces photobleaching and phototoxicity in live-cell imaging

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2024.240035 discusses multiplexed stimulated emission depletion nanoscopy for multi-color live-cell long-term imaging.

23 Jul 2024

Epigenetic insights into stroke-induced immunological changes

A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs - such as the heart.

23 Jul 2024

New strategy for mRNA nanocarriers using triphenyl phosphonium

Among the vastly different ways of tackling a disease, controlling the genetic expression of cells is undoubtedly one of the most powerful. Over the past few decades, scientists have come up with dozens of innovative strategies that involve using messenger RNA (mRNA) to 'force' cells to build specific proteins. These mRNA-based therapies have recently gained prominence as vaccines against infectious diseases like COVID-19. Additionally, they hold significant potential for treating cancer and genetic disorders.

23 Jul 2024

Study: Danger circuit relies on neuropeptides, not neurotransmitters

In the split second as you accidentally touch the hot handle of a cast iron skillet, pain and a sense of danger rush in.

22 Jul 2024

USC scientists transform B cells into cancer and HIV destroyers

USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.

22 Jul 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Study examines brain activity and time perception over minutes and hours

Ever hear the old adage that time flies when you're having fun? A new study by a team of UNLV researchers suggests that there's a lot of truth to the trope.

19 Jul 2024

Blocking IL-11 protein extends lifespan and health in mice by 25%, study shows

Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25%.

18 Jul 2024

Insights into megakaryopoiesis regulation by plasmacytoid dendritic cells

Platelets play an essential role in wound healing. Underproduction can cause devastating bleeding, while overproduction increases the deadly risk of thromboses.

18 Jul 2024

Discovery of over 1,000 undetected proteins in metabolite samples

Van Andel Institute scientists have identified more than 1,000 previously undetected proteins in common metabolite samples, which persist despite extraction methods designed to weed them out.

18 Jul 2024

Harnessing cell's natural delivery system for targeted drug delivery

Each cell in the body has its own unique delivery system that scientists are working on harnessing to move revolutionary biological drugs -; molecules like proteins, RNA and combinations of the two -; to specific diseased parts of the body.

17 Jul 2024

Researchers reveal unique characteristics of previously unexplored protein FAM110A

An international research collaboration, led by Prof. Dr. Robert Grosse (Centre for Integrative Biological Signalling Studies and Institute of Clinical and Experimental Pharmacology and Toxicology, University of Freiburg), Dr. Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences, Prague) and Dr. Zdenek Lansky (Institute of Biotechnology, Czech Academy of Sciences, Prague) has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.

16 Jul 2024

Immune protein C1q impacts neuronal protein synthesis in the aging brain, study reveals

A groundbreaking study conducted at the lab of Beth Stevens, PhD, at Boston Children's Hospital has revealed that an immune protein impacts neuronal protein synthesis in the aging brain.

15 Jul 2024