Cell Biology

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Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

Scientists create a novel cell model for understanding human development

The earliest moments of human development—between the time of fertilization and when the embryo implants in the womb—have remained opaque to scientists.

9 Sep 2021

Highly extensive Gut Cell Atlas will transform research into intestinal diseases

Many diseases have their origin in early human development, and today (8th September), two publications in Nature reveal how researchers from the Human Cell Atlas (HCA) consortium are advancing understanding of this.

9 Sep 2021

Salt tasting cells drive food foraging strategy in nematode worms

Neuroscientists have developed a computer model to explain how a nematode worm searches for food, revealing that single brain cells can both sense the environment and control a whole animal's foraging strategy.

9 Sep 2021

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome-;the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts-;can impact us in a variety of different ways, from our metabolism to our mood.

9 Sep 2021

Researchers develop artificial inorganic cell-like structures to recreate functions of living cells

Researchers have developed artificial cell-like structures using inorganic matter that autonomously ingest, process, and push out material-; recreating an essential function of living cells.

9 Sep 2021

$New tool can rapidly quantify T cell fraction and predict immunotherapy response$

New tool can rapidly quantify T cell fraction and predict immunotherapy response

Scientists at UCL and the Francis Crick Institute, London, have developed a new tool, which can rapidly estimate the number of T cells (immune cells) in a cancerous tumor; with T cell abundance helping predict a patient's response to immunotherapy, researchers are hopeful this could enable more targeted and effective cancer therapies.

8 Sep 2021

Natural killer cells mediate a trade-off between wound healing and bacterial defense

Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds.

8 Sep 2021

Interorgan network plays an essential role in maternal antibody transfer through breastfeeding

Breastfeeding offers an array of benefits for mothers and newborns. Maternal antibodies are transferred via breastfeeding, protecting the gastrointestinal tracts of babies from several pathogen-caused infections.

8 Sep 2021

Researchers find potential new target for treating systemic inflammation in obesity

A study led by researchers at the University of Chicago and Indiana University has determined that a protein called elF5A is necessary for driving inflammation in macrophage cells in obesity.

7 Sep 2021

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.

7 Sep 2021

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Study offers important evidence for the safety of stem cell transplants

Stem cell transplants do not lead to changes in the DNA of the donor cells. That's according to a new study, which provides important evidence for the safety of this procedure.

7 Sep 2021

Research uses rodent models to connect the influence of feronomic signals on memory

The work, published recently in Nature Communications, used a model of rodents and managed to connect for the first time the influence of feronomic signals on memory. This will make it possible to explore the deficits of integration of spatial memories and social studies in transgenic models of Alzheimer's disease in the future.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

As part of its "Life?" project, the Volkswagen Foundation is funding a research project that is placing membraneless organelles within cells in the spotlight as a way of understanding the fundamental processes that are essential to life.

6 Sep 2021

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death.

6 Sep 2021

Cancer treatment with terpyridine platinum compounds induces telomere dysfunction, chromosome instability

Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells" which reported that this assay is based on the use of two isogenic HT1080 cell lines, one carrying a linear HAC and the other carrying a circular HAC.

6 Sep 2021

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Researchers at the Max Planck Florida Institute for Neuroscience have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resolution.

6 Sep 2021

Cell Biology

Cellular program could turn T cells into effective cancer killers

Scientists create a novel cell model for understanding human development

Highly extensive Gut Cell Atlas will transform research into intestinal diseases

Salt tasting cells drive food foraging strategy in nematode worms

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

Researchers develop artificial inorganic cell-like structures to recreate functions of living cells

New tool can rapidly quantify T cell fraction and predict immunotherapy response

Natural killer cells mediate a trade-off between wound healing and bacterial defense

Interorgan network plays an essential role in maternal antibody transfer through breastfeeding

Researchers find potential new target for treating systemic inflammation in obesity

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Study offers important evidence for the safety of stem cell transplants

Research uses rodent models to connect the influence of feronomic signals on memory

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

Cancer treatment with terpyridine platinum compounds induces telomere dysfunction, chromosome instability

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Next-Gen Sequencing And The Diagnosis of Disease

In-depth sequencing of SARS-CoV-2 variants crucial in controlling outbreaks

Increasing your risk of IBD through processed food

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