Cell Biology

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Infant gut microbiomes exhibit circadian rhythms independent of external cues

Infant gut microbiomes oscillate with a circadian rhythm, even when they are cultivated outside of the body.

2 Apr 2024

New technique reveals insights into gut cell dynamics during inflammation

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis.

2 Apr 2024

How neural barcodes shape episodic memory in chickadees

Black-capped chickadees have extraordinary memories that can recall the locations of thousands of morsels of food to help them survive the winter.

29 Mar 2024

Researchers decode the evolutionary pathway of regulatory proteins

New research from the University of Wisconsin–Madison decodes the evolutionary pathway of regulatory proteins, the molecules that help control gene expression.

29 Mar 2024

Human breast cell atlas unveils early changes in BRCA gene mutation carriers

Researchers at the University of Cambridge have created the world's largest catalog of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.

28 Mar 2024

Cells' built-in stopwatch safeguards mitosis

Each day, hundreds of billions of cells in our body cycle through a period of growth and division. Yet in that time, only about 30 minutes is spent on the critical orchestration of mitosis, when chromosomes are carefully segregated from one parent cell to the next generation of two daughter cells.

28 Mar 2024

Dartmouth research unlocks extended cell death pathway in aging brain cells

For oligodendrocytes-;the central nervous system cells critical for brain function-;age may not bring wisdom, but it does come with the power to cling to life for much, much longer than scientists knew.

28 Mar 2024

Sensory neurons play pivotal role in orchestrating tissue repair and regeneration

Researchers from Monash University and Osaka University have unveiled a groundbreaking discovery regarding the pivotal role of sensory neurons in orchestrating tissue repair and regeneration, offering significant promise for patients with poorly healing tissues and diabetes.

27 Mar 2024

Breakthrough tool illuminates neural stem cell dynamics

Researchers can use the light naturally thrown off by biological specimens to better study the different states of stem cells in the nervous system, thanks to a tool developed at the University of Wisconsin–Madison, brightening their chances for studying the way stem cells age.

27 Mar 2024

New treatment paradigm focuses on reverting cancer cells to normal state

St. Jude Children's Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein.

27 Mar 2024

DNA damage in neurons crucial for creating stable memories

Just as you can't make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can't make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.

27 Mar 2024

AI-powered method predicts protein dynamics to accelerate drug discovery

Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them.

27 Mar 2024

GPT-4 shows expert-level accuracy in annotating cell types

GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types – with high consistency to that of time-consuming manual annotation by human experts of gene information, according to a study at Columbia University Mailman School of Public Health.

26 Mar 2024

Unlocking the mysteries of early human development through blastoid models

It's one of life's most defining moments-;that crucial step in embryonic development, when an indistinct ball of cells rearranges itself into the orderly three-layered structure that sets the stage for all to come.

22 Mar 2024

Insights from physics models illuminate biological particle behavior

Erin McCarthy '23, physics summa cum laude, is a rarity among young scientists. As an undergraduate researcher in Syracuse University's College of Arts & Sciences' Department of Physics, she guided a study that appeared in March 2024 in Physical Review Letters. It is the most-cited physics letters journal and the eighth-most cited journal in science overall.

22 Mar 2024

New drug inhibitors target protein linked to Alzheimer's and heart disease

The health impacts of a complex protein that plays a major role in the development of Alzheimer's disease and heart conditions can be lessened by three kinds of drug inhibitors, according to scientists at the University of Colorado Anschutz Medical Campus.

22 Mar 2024

Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

22 Mar 2024

Aging linked to length of genes, study suggests

Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics.

22 Mar 2024

Groundbreaking atlas maps over 80 blood stem cell types

Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children's has published the world's most detailed "atlas" of the many types of stem cells and early progenitors involved in producing human blood from diverse donors.

21 Mar 2024

Study explores how the brain creates a cohesive sense of body position and movement

How does your brain know the position and movement of your different body parts? The sense is known as proprioception, and it is something like a "sixth sense", allowing us to move freely without constantly watching our limbs.

21 Mar 2024