1. Russ Babcock Russ Babcock Canada says:

    If chloroquine products turn out to be effective, it will likely be in a way that halts the progress of the virus (at whatever stage it is at).  I say that because its degree of efficacy is based upon how it interferes with the polymerase that the  virus needs to reproduce itself.  It is not expected to reverse anything, but if it can halt the reproduction of the virus it might be able to give the patient a chance to overcome the virus with his/her immune system if it isn't too far advanced.

    Plasma from recovered and presumably immune cases on the other hand would hopefully contribute the necessary antibodies to overcome the virus.

    I wonder why this approach isn't being seriously investigated?

    • Rosemary B Rosemary B United States says:

      Why are news outlets "reporting" that HCQ and CQ are ineffective?
      I am baffled. I gather the information they are claiming is truth is that the treatment has not been effective on hospitalized severely ill patients.

      Here is the conclusion from NEJM. It seems clear as day that people who are high risk, on the line care workers have benefited quite substantially to the regimen
      Both chloroquine and the derivative molecule hydroxychloroquine have in vitro activity against SARS-CoV and SARS-CoV-2.2,3 Hydroxychloroquine is thought to impair the terminal glycosylation of the angiotensin-converting–enzyme 2 (ACE2) receptor, which is the binding site for the envelope spike glycoprotein and has been shown to inhibit endolysosome function.2,4 In addition, hydroxychloroquine may have greater in vitro activity against SARS-CoV-2 than chloroquine.3

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