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Targeting a key gateway can help treat chronic pain, shows study

Something like a quarter of the world's population suffers from chronic pain at some point. As opposed to acute pain – for example, that feeling after hitting your finger with a hammer – chronic pain may not even have a clear cause, and it can linger for years or lifetimes.

27 Aug 2020

Researchers document comprehensive communication pathways in human cell infected with SARS-CoV-2

In the transmission of signals within the cell which, for example, stimulate cell growth or trigger metabolic processes, phosphate groups play an important biochemical role.

25 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

New approach to chronic pain treatment could bring relief

Something like a quarter of the world's population suffers from chronic pain at some point in their lives. As opposed to acute pain - for example, the feeling after hitting your finger with a hammer - chronic pain may not even have a clear cause, and it can linger for years or lifetimes.

19 Aug 2020

Regeneration of vascular cells is regulated by RNA-binding protein

Through their basic research, physicians at the Heart Center of the University Hospital Bonn have discovered how the communication between individual cells can be influenced with the help of a specific protein.

19 Aug 2020

Research shows how a protein stops cells from attacking their own DNA

Viruses multiply by injecting their DNA into a host cell. Once it enters the intracellular fluid, this foreign material triggers a defense mechanism known as the cGAS-STING pathway.

14 Aug 2020

Researchers discover new method to treat herpes viruses

Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted.

24 Jul 2020

Biologists discover extraordinary regeneration of injured neurons in zebrafish

Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

12 Jul 2020

LMU researchers discover how a microRNA preserves vascular integrity

Ludwig-Maximilian-Universitaet in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis.

4 Jun 2020

‘Terminator’ protein suppresses tumorigenesis

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

3 Jun 2020

Bacteria lurking in cancer cells may affect treatment

Cancer cells are comfy havens for bacteria. That conclusion arises from a rigorous study of over 1,000 tumor samples of different human cancers.

2 Jun 2020

Researchers identify genetic mechanisms that produce radioresistance in cancer cells

Cancer stem cells are a cell type that was previously little known. They are resistant to irradiation and prevent the effective treatment of many types of cancer. A research group from Innsbruck has now identified two genetic mechanisms that produce this radioresistance.

26 May 2020

New genomic method helps obtain high-resolution maps of DNA in the cell nucleus

Researchers at Karolinska Institutet in Sweden have developed a new sequencing method that makes it possible to map how DNA is spatially organised in the cell nucleus - revealing which genomic regions are at higher risk of mutation and DNA damage.

26 May 2020

Clinical trial launched to evaluate experimental COVID-19 therapies

Clinical leaders from the University of Kentucky's Markey Cancer Center, College of Medicine and College of Pharmacy have launched a clinical trial for experimental therapies to treat patients infected with COVID-19.

11 May 2020

Protein shredder in brain cells indirectly regulates fat metabolism

A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism.

8 May 2020

Meis1 protein plays key role in stopping cell division in the heart

UT Southwestern Medical Center scientists have discovered a protein that works with others during development to put the brakes on cell division in the heart, they report today in Nature.

23 Apr 2020

Damaged powerhouses of cells can self-repair in a kind of workshop mode

If the energy supply of a cell is disturbed by damage, it can protect itself from functional losses and repair itself in a kind of workshop mode.

2 Apr 2020

Researchers publish review on HIV-1 Rev Regulatory complex in “Current HIV Research” journal

A team of researchers led by Patrick E. H. Jackson at the Myles H. Thaler Center for HIV and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, USA, has published a review on the subject of the HIV-1 Rev Regulatory complex (dubbed the HIV-1 Rev Regulatory Axis) in the journal, Current HIV Research.

1 Apr 2020

Researchers identify new genetic variants that cause heart disease in infants

Florida State University researchers working in an international collaboration have identified new genetic variants that cause heart disease in infants, and their research has led to novel insights into the role of a protein that affects how the heart pumps blood.

7 Mar 2020