Cocaine Addiction News and Research

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Cocaine dependence (or addiction) is physical and psychological dependency on the regular use of cocaine. It can result in severe physiological damage, psychosis, schizophrenia, lethargy, depression, or a potentially fatal overdose.

Cocaine and heroin increase permeability of the placenta

Cocaine and heroin increase permeability of the placenta. Researchers writing in BioMed Central's open access journal Reproductive Biology and Endocrinology have shown that exposure to the drugs causes an increase in the passage of some chemicals into the fetus.

10 Jun 2009

Catalyst Pharmaceutical Partners announces top-line results of CPP-109 phase II trial for cocaine addiction

Catalyst Pharmaceutical Partners, Inc. has announced top-line results from its U.S. Phase II clinical trial to treat cocaine addiction.

31 May 2009

Impaired ability to monitor behavior, emotions may underlie vulnerability to drugs; suggests new targets for treatment

Parts of the brain involved in monitoring behaviors and emotions show different levels of activity in cocaine users relative to non-drug users, even when both groups perform equally well on a psychological test.

25 May 2009

A new path for cocaine addiction research

Cocaine is one of the oldest drugs known to humans, and its abuse has become widespread since the end of the 19th century. At the same time, we know rather little about its effects on the human brain or the mechanisms that lead to cocaine addiction.

19 May 2009

Research shows how cocaine regulates gene expression in a crucial reward region

The study, published by Cell Press in the May 14th issue of the journal Neuron, provides exciting insight into the molecular pathways regulated by cocaine and may lead to new strategies for battling drug addiction.

13 May 2009

Promising new targets for medications to treat cocaine addiction

Repeated use of addictive drugs such as cocaine causes long-lasting changes in parts of the brain involved in motivation and reward, among others, yet the precise mechanisms by which these changes are maintained are poorly understood.

13 May 2009

Scientists use eye tracking to detect mild dementia in humans

Researchers at the Yerkes National Primate Research Center, Emory University, developed a test in nonhuman primates that is now using infrared eye tracking to detect mild cognitive impairment (MCI) in humans.

15 Apr 2009

Blocking hunger hormone helps fight cocaine addiction

UC Irvine pharmacological researchers have discovered that blocking a hormone related to hunger regulation can limit cocaine cravings.

1 Apr 2009

Recent drug use masks cocaine abusers' cognitive impairment

Recent cocaine use may hide some of the cognitive deficits commonly experienced by individuals addicted to cocaine, scientists at the U.S. Department of Energy's Brookhaven National Laboratory report in a study published in the April 2009 issue of Neuropsychopharmacology - a special issue dedicated to cocaine research.

3 Mar 2009

Researchers discover gene variation linked to cocaine addiction and cocaine-induced paranoia

Researchers from Boston University School of Medicine (BUSM) and Yale University School of Medicine and the University of Connecticut School of Medicine, have discovered that variants in the á-endomannosidase (MANEA) gene are associated with cocaine addiction and cocaine-induced paranoia in European American and African American populations.

2 Mar 2009

Drug-related preference in cocaine addiction extends to images

When given a choice between viewing pictures of cocaine and a variety of other images, cocaine addicted individuals, as compared to healthy, non-addicted research subjects, show a clear preference for the drug-related images.

16 Nov 2008

Study sheds light on why addiction is a chronic disease

Drug addiction dramatically shifts a person's attention, priorities, and behaviors towards a focus almost entirely on seeking out and taking drugs. Now, an animal study funded by the National Institute on Drug Abuse, part of the National Institutes of Health, has identified some of the specific long-term adaptations in the brain's reward system that may contribute to this shift.

31 Jul 2008

Molecular fingerprint of cocaine addiction revealed

The first large-scale analysis of proteins in the brains of monkeys addicted to cocaine reveals new information on how long-term cocaine use changes the amount and activity of various proteins affecting brain function.

27 May 2008

Yerkes researchers develop first transgenic nonhuman primate model of Huntington's disease

In the first study of its kind, researchers at the Yerkes National Primate Research Center, Emory University, in collaboration with researchers from the Department of Human Genetics at Emory's School of Medicine, have developed the first transgenic nonhuman primate model of Huntington's disease (HD), one of the most devastating human neurodegenerative diseases.

22 May 2008

New research in monkeys may lead to new strategy for treating cocaine addiction

New research in monkeys suggests the feasibility of treating cocaine addiction with a "replacement" drug that mimics the effects of cocaine but has less potential for abuse - similar to the way nicotine and heroin addictions are treated.

7 Apr 2008

Animal research shows potential of amphetamine-like drug for treating cocaine addiction

7 Apr 2008

Researchers model emotional impact of cocaine in rats

Cocaine addicts often suffer a downward emotional spiral that is a key to their craving and chronic relapse.

13 Mar 2008

Diltiazem reduces cocaine cravings in a rat model

Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model.

28 Feb 2008

New method enables design, production of extremely novel drugs

A new chemical synthesis method based on a catalyst worth many times the price of gold and providing a far more efficient and economical method than traditional ones for designing and manufacturing extremely novel pharmaceutical compounds is described by its University at Buffalo developers in a review article in the current issue of Nature.

24 Jan 2008