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New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

Study reveals pan-antiviral properties of PDC-109 bovine seminal plasma protein

In a new study, researchers explored the antiviral activity of the bovine seminal plasma protein PDC-109 against various mammalian viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Sep 2022

Bivalent recombinant vaccine protects against SARS-CoV-2 and influenza in animal models

In a new study, researchers developed a recombinant bivalent vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses.

15 Sep 2022

Concern over two cases of monkeypox-related neurological complications in the U.S.

A new study published in the CDC's Morbidity and Mortality Weekly Report analyzed two people with encephalomyelitis associated with monkeypox disease in Colorado and DC during the current outbreak.

15 Sep 2022

Brain injury a common consequence of both COVID-19 and influenza

In a recent study published in the journal Brain, researchers reported that brain injury is common in coronavirus disease 2019 (COVID-19) and influenza.

12 Sep 2022

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Researchers explored probable humoral immune mechanisms related to EBV curtailment, besides neutralization, by a systematic emphasis on antibody fragment crystallizable-functional activities over the course of EBV infections.

9 Sep 2022

Study suggests entry of SARS-CoV-2 requires an acidic pH

Researchers carried out real-time single-virion tracking in three dimensions to study the mechanisms and requirements of membrane attachment and fusion of SARS-CoV-2 with the host cell.

6 Sep 2022

The possible association between SARS-CoV-2, ACE2, TMPRSS2, and skin manifestations

A new study analyzed the possibility of penetration of SARS-CoV-2 into the skin.

5 Sep 2022

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

In a new study, researchers assessed the effects of N501Y mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein on binding to angiotensin-converting enzyme-2 (ACE-2).

1 Sep 2022

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

A new study explored the glycan shield diversity of sarbecoviruses, furthering the knowledge for developing broad-range pan-coronavirus vaccines.

30 Aug 2022

How natural alterations inside the SARS-CoV-2 glycan barrier affect spike protein dynamics

Researchers explored how the natural alterations inside the SARS-CoV-2 glycan barrier affect the spike protein dynamics.

22 Aug 2022

GPNMB established as a risk gene and potential therapeutic target for Parkinson's disease

Computational, cell biological, and human tissue-based studies establish GPNMB as a risk gene and potential therapeutic target for Parkinson's Disease (PD), researchers report.

18 Aug 2022

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

Researchers investigated the role of the CD98 glycoprotein in inducing an inflammatory response to SARS-CoV-2 in patients of progressive fibrosis interstitial lung diseases, including the archetypal PFILD, idiopathic pulmonary fibrosis.

18 Aug 2022

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Researchers demonstrated the relevance of the P681H spike mutation in the SARS-CoV-2 Alpha variant.

17 Aug 2022

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

In a new study, researchers explored sphingosine kinases inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry.

16 Aug 2022

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

In a new study, scientists identified an unmodified peptide addressing pre-hairpin spike (S) protein intermediate inhibiting SARS-CoV-2 infection.

15 Aug 2022

Post-illness metabolomic and gut-microbiome profiles in community-dwelling participants with SARS-CoV-2

Researchers explored post-illness gut-microbiome and metabolomic profiles of community COVID-19 cases and individuals with non-COVID-19 illnesses of prolonged duration.

15 Aug 2022

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

A new study reviews recent advancements made in the development of RSV immunoprophylactic measures.

11 Aug 2022

How does the interval between the 1st and 2nd BNT162b2 doses impact the neutralization breadth and potency against variants of concern?

Scientists explored the influence of SARS-CoV-2 extended gap vaccination on the variants of concern neutralization.

9 Aug 2022

Glycoprotein News and Research

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

Study reveals pan-antiviral properties of PDC-109 bovine seminal plasma protein

Bivalent recombinant vaccine protects against SARS-CoV-2 and influenza in animal models

Concern over two cases of monkeypox-related neurological complications in the U.S.

Brain injury a common consequence of both COVID-19 and influenza

The evolution of humoral immune responses over the course of Epstein-Barr virus infection

Study suggests entry of SARS-CoV-2 requires an acidic pH

The possible association between SARS-CoV-2, ACE2, TMPRSS2, and skin manifestations

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

How natural alterations inside the SARS-CoV-2 glycan barrier affect spike protein dynamics

GPNMB established as a risk gene and potential therapeutic target for Parkinson's disease

CD98 identified as a key mediator of pro-fibrotic and acute inflammatory responses in the lung

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

Scientists explore nanomolar inhibition of SARS-CoV-2 infection via unmodified peptide targeting spike protein pre-hairpin intermediate

Post-illness metabolomic and gut-microbiome profiles in community-dwelling participants with SARS-CoV-2

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

How does the interval between the 1st and 2nd BNT162b2 doses impact the neutralization breadth and potency against variants of concern?

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