Melanoma Cells News and Research

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Injection of genetically modified virus effectively treats metastatic melanoma patients

Injection of a genetically modified virus that induces the body's own immune cells to attack metastatic melanoma effectively treated almost 40 percent of patients with tumors that could not be surgically removed, according to researchers from three prominent cancer centers in a study published as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication.

28 Jan 2019

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.

23 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

Melanoma cells put to sleep by T cells improving outcomes, find researchers

Australian researchers have found that special immune cells of the body not only protect us from the invading bacteria, viruses and microbes but also play a role in reducing the aggressiveness of the melanoma cells.

1 Jan 2019

Researchers discover how MAPK translocation leads to drug resistance in melanoma

Researchers have discovered that the ER translocation of MAPK leads to drug resistance in melanoma.

18 Dec 2018

New drug combination could kill melanoma cells more effectively, study shows

A class of cancer drugs called protein kinase inhibitors is one of the most effective treatments for melanoma. However, in many cases, tumors eventually become resistant to the drugs and cause a relapse in the patient.

3 Dec 2018

Using molecular targeting approach to kill melanoma cells

In 1960, scientists described the "Philadelphia chromosome" that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic change.

27 Nov 2018

New City of Hope CAR T cell trial focuses on HER2-positive breast cancer patients with brain metastases

Women with HER2-positive breast cancer that has spread to the brain need more treatment options, and City of Hope and Mustang Bio Inc. are meeting that challenge.

30 Oct 2018

Study suggests new strategy to kill melanoma cells

Think of the protein BH3 like a finger that turns off a cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger" - commonly, by breaking the action of a gene called p53 that puts the BH3 finger in motion. Now think of Bcl-2 as the switch itself.

24 Oct 2018

Study unravels how cancer stem cells use normal genes in abnormal ways

CDK1 is a "normal" protein - its presence drives cells through the cycle of replication. And MHC Class I molecules are "normal" as well - they present bits of proteins on the surfaces of cells for examination by the immune system.

15 Oct 2018

Changes in skin and lymphatic system due to age facilitate melanoma metastasis

Changes in the structure of the skin and the lymphatic system that occur with the natural aging process create permissive conditions for melanoma metastasis, according to two studies by The Wistar Institute.

3 Oct 2018

Highly personalized approach may help immune cells to eliminate melanoma

With new immunotherapy treatments for melanoma, recovery rates have risen dramatically, in some cases to around 50%.

12 Sep 2018

Natural plant compound exploits newly identified Achilles' heel in uveal melanoma

A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis.

6 Sep 2018

Researchers discover natural plant compound that shuts down uveal melanoma cell growth

A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma.

6 Sep 2018

Cancer cells release biological 'drones' to assist in the fight against immune system

Cancer cells are more than a lump of cells growing out of control; they participate in active combat with the immune system for their own survival. Being able to evade the immune system is a hallmark of cancer.

9 Aug 2018

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Tafinlar® in combination with Mekinist® for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection.

27 Jul 2018

Melanoma Cells News and Research

Injection of genetically modified virus effectively treats metastatic melanoma patients

Ludwig researchers find ways to make resistant melanomas susceptible to immunotherapy

FDA-approved drug hampers cancer metastasis in animal model, shows study

Melanoma cells put to sleep by T cells improving outcomes, find researchers

Researchers discover how MAPK translocation leads to drug resistance in melanoma

New drug combination could kill melanoma cells more effectively, study shows

Using molecular targeting approach to kill melanoma cells

New City of Hope CAR T cell trial focuses on HER2-positive breast cancer patients with brain metastases

Study suggests new strategy to kill melanoma cells

Study unravels how cancer stem cells use normal genes in abnormal ways

Changes in skin and lymphatic system due to age facilitate melanoma metastasis

Highly personalized approach may help immune cells to eliminate melanoma

Natural plant compound exploits newly identified Achilles' heel in uveal melanoma

Researchers discover natural plant compound that shuts down uveal melanoma cell growth

Cancer cells release biological 'drones' to assist in the fight against immune system

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments

Cilia appears to play key role in formation of melanoma

Researchers uncover new therapeutic opportunity in the treatment of malignant melanoma

New technique aims to expand understanding of mechanical forces existing between cells

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