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SLU researchers make advances in understanding plaque-causing protein in neurological disorders

In a recent paper published in the Journal of Biological Chemistry Yuna Ayala, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, and her research team made advances in understanding how a protein causes damaging plaques to build up in neurodegenerative illnesses like amyotrophic lateral sclerosis (ALS) and a form of dementia called frontotemporal lobar degeneration.

19 Apr 2017

Brain cancer patient treated with malaria drug shows dramatic improvement

After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl's doctors gave her only a few months to live.

19 Apr 2017

New blood test can accurately, quickly identify genetic mutations linked to NSCLC

Identification of a specific genetic mutation in patients with non-small-cell lung cancer (NSCLC) helps clinicians select the best treatment option. Potential NSCLC patients usually undergo invasive tissue biopsy, which may often be unnecessary and delays treatment.

19 Apr 2017

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

Scientists discover promising target to treat highly aggressive brain tumor in infants

Using state-of-the-art gene editing technology, scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a promising target to treat atypical teratoid/rhabdoid tumor (AT/RT) – a highly aggressive and therapy resistant brain tumor that mostly occurs in infants.

11 Apr 2017

Feeding status alters the human adipose tissue response to exercise, study reveals

Time and again, fitness enthusiasts have a question–to exercise before or after breakfast. A new study published online in the American Journal of Physiology—Endocrinology and Metabolism has highlighted the role of fat toward metabolism. This is the first study that reveals the effects of fasting and feed status on human adipose tissue responses to exercise.

11 Apr 2017

Muscle genetics plays crucial role in success of marathon runners, study shows

For a few years, running has been fashionable. But there is a great difference between the physical demands of running a few kilometres and doing a marathon. Now Spanish researchers have concluded that genetics plays an essential role in success when completing this long distance.

6 Apr 2017

Scientists find new drug target to improve cardiac output in heart failure patients

Researchers led by Julian E. Stelzer, PhD, associate professor in the department of physiology and biophysics at Case Western Reserve University School of Medicine, have found a new target for drug developers seeking straightforward ways to improve cardiac output in heart failure patients.

4 Apr 2017

Investigational compound for treating indolent lymphomas shows positive results in phase II clinical study

Bayer today announced positive data on its investigational compound copanlisib, an intravenous pan-Class I phosphatidylinositol-3-kinase (PI3K) inhibitor with predominant inhibitory activity against PI3K-α and PI3K-δ isoforms.

31 Mar 2017

Study shows marathon participation causes temporary injury to kidneys

Researchers at Yale University have found that marathon runners can suffer Acute Kidney Injury (AKI), due to the physical tension they experience while running the race. Although AKI is a temporary injury that heals within a span of two days after the race, questions arise about the long-term impacts of this exhausting task over.

30 Mar 2017

Researchers shed light on diverse effects of exercise on individuals

In Japan, due to the changes of lifestyle such as less physical activities than before, more and more people suffer from the lifestyle diseases like metabolic syndromes, type-2 diabetes and hypertension.

28 Mar 2017

Study shows how zinc regulates storage and release of neurotransmitters

Zinc is a vital micronutrient involved in many cellular processes: For example, in learning and memory processes, it plays a role that is not yet understood. By using nanoelectrochemical measurements, Swedish researchers have made progress toward understanding by demonstrating that zinc influences the release of messenger molecules.

22 Mar 2017

Study identifies potential Achilles heel of kinase-driven cancers

Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models.

22 Mar 2017

New Danish research provides structural knowledge of DNA repair complex

New Danish research provides mechanistic insight into how DNA is monitored and repaired if damage occurs. The results may eventually help to improve the treatment of certain types of cancer, as the DNA repair complex provides a mechanism for cancer cells to resist chemotherapy.

21 Mar 2017

Penn studies provide new understanding of lung cancer progression and prevention

Treating the brain with a preventative course of radiation may help Small Cell Lung Cancer (SCLC) patients - whose tumors often spread to their brain -- live longer, according to a new study from researchers in the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania.

16 Mar 2017

MPFI researchers develop new tool to study CaMKII kinetics in learning and memory

As we learn, the structure of individual neurons in our brains change to strengthen important connections and weaken less important ones, a process known as structural plasticity.

16 Mar 2017

Researchers identify underlying cause of obsessive-compulsive disorder

An overactive molecular signal pathway in the brain region of the amygdala can lead to obsessive-compulsive disorder (OCD). A research team from Würzburg has established this connection.

16 Mar 2017

Topical curcumin gel improves healing of burns and scalds

What is the effect of Topical Curcumin Gel for treating burns and scalds? In a recent research paper, published in the open access journal BioDiscovery, Dr. Madalene Heng, Clinical Professor of Dermatology at the David Geffen School of Medicine, stresses that use of topical curcumin gel for treating skin problems, like burns and scalds, is very different, and appears to work more effectively, when compared to taking curcumin tablets by mouth for other conditions.

14 Mar 2017

Scientists pinpoint key biological mechanism that can prevent proliferation of insulin-producing cells

If you become resistant to insulin, a condition that is a precursor to type 2 diabetes, your body tries to compensate by producing more of the "beta" cells in the pancreas that produce the critical hormone.

9 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

Kinase News and Research

SLU researchers make advances in understanding plaque-causing protein in neurological disorders

Brain cancer patient treated with malaria drug shows dramatic improvement

New blood test can accurately, quickly identify genetic mutations linked to NSCLC

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

Scientists discover promising target to treat highly aggressive brain tumor in infants

Feeding status alters the human adipose tissue response to exercise, study reveals

Muscle genetics plays crucial role in success of marathon runners, study shows

Scientists find new drug target to improve cardiac output in heart failure patients

Investigational compound for treating indolent lymphomas shows positive results in phase II clinical study

Study shows marathon participation causes temporary injury to kidneys

Researchers shed light on diverse effects of exercise on individuals

Study shows how zinc regulates storage and release of neurotransmitters

Study identifies potential Achilles heel of kinase-driven cancers

New Danish research provides structural knowledge of DNA repair complex

Penn studies provide new understanding of lung cancer progression and prevention

MPFI researchers develop new tool to study CaMKII kinetics in learning and memory

Researchers identify underlying cause of obsessive-compulsive disorder

Topical curcumin gel improves healing of burns and scalds

Scientists pinpoint key biological mechanism that can prevent proliferation of insulin-producing cells

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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