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Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

Researchers evaluated the tolerability, safety, pharmacodynamics, and pharmacokinetic properties of muvalaplin.

30 Aug 2023

High-fiber diets may help control the adverse effects of antibiotic treatments on beneficial gut microbiota

The role of diet in controlling the structure and function of the gut via chemical environment modulation.

30 Aug 2023

Modern blood thinners linked to reduced risk of bleeding

Modern blood-thinning drugs (known as NOACs) reduce the risk of serious bleeding by up to 45 percent compared to the traditional drug Waran in the treatment of blood clots in the legs and lungs.

29 Aug 2023

Early initiation of dapagliflozin in acute decompensated heart failure does not improve diuretic efficiency

Early initiation of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin did not result in a statistically significant improvement in diuretic efficiency relative to structured usual care in hospitalized patients with acute decompensated heart failure (ADHF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

Longer duration of anticoagulation therapy benefits cancer patients with isolated distal DVT

Twelve months of edoxaban is superior to three months for the reduction of thrombotic events in patients with cancer and distal deep vein thrombosis (DVT), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

Is obesity associated with risk of head and neck cancer?

The association between obesity and head and neck cancer risk.

29 Aug 2023

Could automated, saliva-based PCR testing be the future of COVID-19 surveillance?

In a large-scale study funded by Kings College London, researchers successfully implemented an automated PCR-based testing program for SARS-CoV-2 using saliva samples from asymptomatic students and staff. The system achieved 85% sensitivity and 100% specificity, provided rapid results within eight hours, and offered a cost-effective and scalable approach to community surveillance of COVID-19.

28 Aug 2023

Experts warn of unintended consequences of using GLP-1RAs to treat childhood obesity

A team of clinicians, exercise scientists, pharmaceutical scholars, ethicists and behavioral experts at the University of California, Irvine, outlined their concerns that the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) to treat childhood obesity and type 2 diabetes may have unintended and adverse consequences for children's health.

28 Aug 2023

Acoramidis shows potential to be effective, safe treatment for transthyretin amyloid cardiomyopathy

Acoramidis improves outcomes in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) compared with placebo, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Switching to NOACs in frail elderly patients with atrial fibrillation increases bleeding risk

Switching vitamin K antagonist (VKA) treatment to a non-vitamin K antagonist oral anticoagulant (NOAC) in frail elderly patients with atrial fibrillation is associated with more bleeding complications compared to continuing VKA treatment.

28 Aug 2023

First oral treatment for Lipoprotein(a) shows significant cholesterol reduction

A new drug offers a breakthrough world first treatment for Lipoprotein(a), a largely genetic form of cholesterol that increases the risk of heart attack and stroke, announced today by study lead Professor Stephen Nicholls, Director of the Monash University's Victorian Heart Institute and Victorian Heart Hospital.

28 Aug 2023

New guideline supports use of acetaminophen and NSAIDs for pediatric dental pain

Acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are recommended as first-line treatments for managing short-term dental pain in children under age 12, according to a new clinical practice guideline developed by the American Dental Association Science & Research Institute (ADASRI), the University of Pittsburgh School of Dental Medicine and the Center for Integrative Global Oral Health at the University of Pennsylvania School of Dental Medicine.

25 Aug 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

UofL researchers receive $11.7 million to study microorganisms throughout the body

University of Louisville researchers have received $11.7 million to study microorganisms throughout the body, including the mouth. What they find could lead to better understanding and treatment of a range of chronic conditions.

25 Aug 2023

Study shows not all adrenal carcinoma patients need mitotane after surgery

After the complete tumor resection, not all patients with an adrenocortical carcinoma require the previous standard therapy Mitotane. Professors Martin Fassnacht and Massimo Terzolo show this in a clinical trial.

25 Aug 2023

Focused update of ESC Heart Failure Guidelines integrates latest evidence-based treatments

A focused update of the European Society of Cardiology (ESC) Heart Failure Guidelines is published online today in European Heart Journal following the results of major new trials that should change the management of patients with heart failure.

25 Aug 2023

NOAH-AFNET 6 trial: Oral anticoagulation not recommended for patients with atrial high rate episodes

Blood thinners (anticoagulants) cause bleeding without preventing stroke in patients with atrial high rate episodes (AHRE), but without electrocardiogram (ECG)-diagnosed atrial fibrillation, according to late breaking research presented in a Hot Line session today at ESC Congress 2023 and simultaneously published in the New England Journal of Medicine.

25 Aug 2023

Colchicine does not reduce perioperative AF or MINS in major non-cardiac thoracic surgery

Colchicine does not significantly reduce perioperative atrial fibrillation (AF) or myocardial injury after non-cardiac surgery (MINS) in patients undergoing major non-cardiac thoracic surgery, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

25 Aug 2023

Patients with heart conditions should practice good hygiene to prevent infective endocarditis

Patients with specific cardiac conditions such as valvular heart disease and congenital abnormalities, or those requiring a pacemaker, should practice good dental and skin hygiene to help prevent rare but potentially deadly infections of the heart's inner lining and valves, according to European Society of Cardiology (ESC) Guidelines on infective endocarditis, published online today in European Heart Journal.

25 Aug 2023

Fatty acid combination supplement improves visual function in preterm babies

Preterm babies given a supplement with a combination of omega-3 and omega-6 fatty acids have better visual function by the age of two and a half. This has been shown by a study at the University of Gothenburg.

24 Aug 2023

Oral News and Research

Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

High-fiber diets may help control the adverse effects of antibiotic treatments on beneficial gut microbiota

Modern blood thinners linked to reduced risk of bleeding

Early initiation of dapagliflozin in acute decompensated heart failure does not improve diuretic efficiency

Longer duration of anticoagulation therapy benefits cancer patients with isolated distal DVT

Is obesity associated with risk of head and neck cancer?

Could automated, saliva-based PCR testing be the future of COVID-19 surveillance?

Experts warn of unintended consequences of using GLP-1RAs to treat childhood obesity

Acoramidis shows potential to be effective, safe treatment for transthyretin amyloid cardiomyopathy

Switching to NOACs in frail elderly patients with atrial fibrillation increases bleeding risk

First oral treatment for Lipoprotein(a) shows significant cholesterol reduction

New guideline supports use of acetaminophen and NSAIDs for pediatric dental pain

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

UofL researchers receive $11.7 million to study microorganisms throughout the body

Study shows not all adrenal carcinoma patients need mitotane after surgery

Focused update of ESC Heart Failure Guidelines integrates latest evidence-based treatments

NOAH-AFNET 6 trial: Oral anticoagulation not recommended for patients with atrial high rate episodes

Colchicine does not reduce perioperative AF or MINS in major non-cardiac thoracic surgery

Patients with heart conditions should practice good hygiene to prevent infective endocarditis

Fatty acid combination supplement improves visual function in preterm babies

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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