Receptor News and Research

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Engineered SNIPRs transform CAR T-cell precision for safer cancer therapy

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR T-cells. This breakthrough enhances tumor targeting while reducing off-target effects, paving the way for advanced synthetic biology applications.

17 Nov 2024

Obesity crisis in the U.S. expected to worsen by 2050

Over the past three decades, there has been a startling increase in the prevalence of obesity across the USA, at least doubling in adult men and women (aged 25 and older) and older female and male adolescents (aged 15-24 years) since 1990, with the number of people living with overweight and obesity reaching over 208 million in 2021 - a trend set to continue in the coming decades without significant reform, according to a major new analysis from the Global Burden of Disease Study Collaborator Network, published in The Lancet.

15 Nov 2024

Duke-NUS team develops test to monitor engineered T cells in cancer treatment

A novel test developed by Duke-NUS researchers enables real-time monitoring of T cells that have been engineered to fight cancer, after re-introduction into the body of a cancer patient.

15 Nov 2024

Psychedelics may offer anxiety relief through specific brain circuits

New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics.

15 Nov 2024

New discovery reveals NMDAR's critical function in maintaining brain stability

Researchers at Tel Aviv University have made a fundamental discovery: the NMDA receptor (NMDAR) - long studied primarily for its role in learning and memory - also plays a crucial role in stabilizing brain activity.

15 Nov 2024

Customizable biological sensors activate cancer immunotherapy only in tumor environments

Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor cells.

15 Nov 2024

Study reveals high-resolution structure of blood pressure-regulating receptor

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable better drug targeting of the receptor for diseases like hypertension and heart failure.

15 Nov 2024

Diabetes medication shows promise in reducing alcohol use

New research, led by experts at the University of Nottingham, has found that certain types of medication used to treat diabetes may be effective in reducing alcohol use.

15 Nov 2024

Futuristic AI-powered virtual lab designs potent SARS-CoV-2 nanobodies

AI-human collaboration in a "Virtual Lab" successfully designs and experimentally validates nanobodies with enhanced binding to SARS-CoV-2 variants, offering a novel approach to interdisciplinary research.

14 Nov 2024

Tirzepatide significantly reduces weight and diabetes risk in patients with obesity and prediabetes

Tirzepatide shows promise in reducing weight and preventing diabetes progression in people with obesity and prediabetes, with lasting benefits and manageable side effects.

14 Nov 2024

Scientists map cancer mutations in EGFR gene, revealing drug resistance paths

Researchers used base and prime editing to uncover new EGFR gene mutations that affect cancer progression and drug resistance, paving the way for personalized treatment strategies.

14 Nov 2024

CAR T cell therapy breakthroughs bring new hope for treating solid tumors

Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor environments, with promising clinical results.

13 Nov 2024

Scientists discover new breakthrough in weight loss and diabetes treatment

Scientists at the University of Copenhagen have discovered a new weight loss drug target that reduces appetite, increases energy expenditure, and improves insulin sensitivity without causing nausea or loss of muscle mass.

13 Nov 2024

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Professor Nancy Ip discusses her groundbreaking neuroscience research, focusing on neurotrophic factors and innovative Alzheimer's disease treatment approaches.

13 Nov 2024

Study provides new insights into the central role of goblet cells

In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells - specialized cells that line the gut - in maintaining a healthy and balanced immune environment within the gastrointestinal (GI) tract.

12 Nov 2024

New biomarker could help predict Parkinson’s disease progression

A team of researchers from the University of Barcelona and the Bellvitge Biomedical Research Institute (IDIBELL) has identified a potential biomarker of Parkinson's disease progression.

12 Nov 2024

Vitamin D receptor activation slows cell overgrowth in pulmonary hypertension

The study demonstrates that activating the vitamin D receptor (VDR) with calcitriol suppresses cell proliferation in pulmonary arterial smooth muscle cells, potentially reducing disease severity in pulmonary arterial hypertension (PAH).

12 Nov 2024

Breakthrough method sheds light on how immune receptors detect infections

Researchers from the University of Bonn are using an innovative method to watch immune receptors go about their business.

12 Nov 2024

Neuropeptides influence T cell differentiation during viral infections

T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pathogens, or TH2 cells, which fight against extracellular pathogens like bacteria and parasites.

12 Nov 2024

GLP-1 and SGLT2 inhibitors show promise in preventing recurrent stroke and heart attack

GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss, may reduce the risk of heart attack, second strokes and death in adults who had an initial stroke, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.

11 Nov 2024