OCT News and Research

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Ancient viral DNA in human genomes protects cells against present-day viruses

Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.

27 Oct 2022

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukaemia, who had otherwise exhausted all available therapies.

27 Oct 2022

Newly developed chemical compounds show promise as potential anticancer therapy

A University of Kentucky Markey Cancer Center researcher's team developed new chemical compounds that show promise as a potential anticancer therapy to treat aggressive tumors.

27 Oct 2022

RNA-sensing platform could help detect and selectively kill tumors, or edit the genome in specific cells

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have developed a system that can detect a particular RNA sequence in live cells and produce a protein of interest in response.

27 Oct 2022

Study sheds light on why some patients respond better than others to immunotherapy

Immunotherapy, a biotherapy that boosts the ability of the immune system to recognize and attack mutant tumor cells, has transformed the treatment landscape for patients battling cancer, which emerges from the progressive accumulation of DNA mutations.

27 Oct 2022

Seeing or hearing birds linked with an improvement in mental wellbeing

New research from King's College London has found that seeing or hearing birds is associated with an improvement in mental wellbeing that can last up to eight hours.

27 Oct 2022

Researchers find a switch to regulate the diabetes-causing gene

Researchers at the Centre for Genomic Regulation and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes.

27 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

In a recent study that represents the largest to date to examine the severity of the SARS-CoV-2 Omicron BA.2 subvariant (the strain making a re-emergence this fall), a team led by investigators at Massachusetts General Hospital (MGH) determined that the BA.2 subvariant is less severe than the previous Delta variant and less severe to an even greater extent than the original Omicron variant.

27 Oct 2022

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

27 Oct 2022

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Two related studies, one in humans and the other in rats, found that the cardiovascular effects of cigarettes and e-cigarettes are strikingly similar, and these harmful effects on blood vessel function are likely caused by airway irritation due to inhalation of a foreign substance, rather than a specific component of the cigarette smoke or e-cigarette vapor (aerosol), according to new research published today in the American Heart Association's peer-reviewed journal Arteriosclerosis, Thrombosis and Vascular Biology.

27 Oct 2022

Hydrogel bioink can bioprint conduits that mimic the mechanics of native blood vessels

Cardiovascular diseases (CVDs) remain among the leading causes of global morbidity and mortality. In patients with CVD, blood vessels-which transport blood, oxygen, and nutrients-can become constricted or obstructed, leading to numerous complications.

27 Oct 2022

Employers are concerned about covering workers’ mental health needs, survey finds

Almost three years after the covid-19 pandemic upended workplaces, mental health coverage remains a priority for employers, according to an annual employer survey fielded by KFF.

27 Oct 2022

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

As part of an interdisciplinary project of the LOEWE Centre Frankfurt Cancer Institute (FCI), researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in identifying a new approach for the therapy of colorectal cancer.

27 Oct 2022

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

A subset of healthcare workers vaccinated against COVID-19 had unexpectedly low responses to the immunizations, according to Cedars-Sinai investigators.

27 Oct 2022

Low-carb diet may be a useful approach for preventing and treating Type 2 diabetes

While low-carb diets are often recommended for those being treated for diabetes, little evidence exists on whether eating fewer carbs can impact the blood sugar of those with diabetes or prediabetes who aren't treated by medications.

26 Oct 2022

Strongest evidence to date that lowering blood pressure in later life can cut dementia risk

A global study of over 28,000 people has provided the strongest evidence to date that lowering blood pressure in later life can cut the risk of dementia.

26 Oct 2022

Multiple outpatient visits are key to success opioid-use disorder treatment

People with opioid-use disorder who enter treatment are at risk for relapse, overdose or death if they engage in less than two outpatient visits in their first month of care, according to a study coauthored by Rutgers researchers.

26 Oct 2022

Early temperamental and neurocognitive risk factors may play a role in future anxiety, depression

A recent imaging study led by a scientist at The University of Texas at Dallas has identified early risk factors linked to children's temperament and a neural process that could foretell whether an individual might develop depression and anxiety in adolescence and early adulthood.

26 Oct 2022

New studies point to a broadly applicable treatment for neurodegenerative diseases

Two new studies from Washington University School of Medicine in St. Louis support development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that serves as the central executioner in the death of axons, the wiring of the nervous system.

26 Oct 2022

OCT News and Research

Ancient viral DNA in human genomes protects cells against present-day viruses

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Newly developed chemical compounds show promise as potential anticancer therapy

RNA-sensing platform could help detect and selectively kill tumors, or edit the genome in specific cells

Study sheds light on why some patients respond better than others to immunotherapy

Seeing or hearing birds linked with an improvement in mental wellbeing

Researchers find a switch to regulate the diabetes-causing gene

Advanced type of nanoparticle could help fight hard-to-treat cancers

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Hydrogel bioink can bioprint conduits that mimic the mechanics of native blood vessels

Employers are concerned about covering workers’ mental health needs, survey finds

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

Low-carb diet may be a useful approach for preventing and treating Type 2 diabetes

Strongest evidence to date that lowering blood pressure in later life can cut dementia risk

Multiple outpatient visits are key to success opioid-use disorder treatment

Early temperamental and neurocognitive risk factors may play a role in future anxiety, depression

New studies point to a broadly applicable treatment for neurodegenerative diseases

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