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Arsenic trioxide could be powerful therapy to extend lives of certain glioblastoma patients

From Sherlock Holmes to Agatha Christie, arsenic is often the poison of choice in popular whodunits. But in ultra-low dosage, and in the right form, this naturally occurring chemical element can be a potent force against cancer.

17 Oct 2017

Genetic diversity plays major role in evolution of drug resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists at the Wellcome Trust Sanger Institute and the Institute for Research on Cancer and Ageing of Nice in France, show that high genetic diversity can prime new mutations that cause drug resistance.

17 Oct 2017

Study uses precision medicine approach to find effective treatments for rare cancers

For the first time, researchers have been able to identify effective treatments for patients with rare cancers by analyzing genes and proteins in their blood and tumors. In a study reported in The Oncologist, half the patients receiving these targeted treatments saw their rare cancers either stabilize, shrink or go into remission.

17 Oct 2017

Study sheds new light on why autism is more common in boys

Researchers aiming to understand why autism spectrum disorders (ASD) are more common in boys have discovered differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism-causing genetic glitch.

17 Oct 2017

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological strategies that mitigate this defect.

17 Oct 2017

Most ovarian cancers start in the fallopian tubes, study finds

Most - and possibly all - ovarian cancers start, not in ovaries, but instead in the fallopian tubes attached to them.

17 Oct 2017

Using AFM to study cell mechanics and function

My lab, broadly speaking, is interested in trying to understand interactions between cells and materials. Those could be materials that are present within living tissue or materials that we use for engineering purposes to try to do something of technological or therapeutic interest.

From Bruker Nano Surfaces and Metrology 17 Oct 2017

Novel gene expression signature assay could help enhance lymphoma management

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer and the most frequently diagnosed non-Hodgkin lymphoma worldwide (nearly 40% of cases). Recent advancements indicate that both the prognosis and choice of treatment of DLBCL may depend on identifying its molecular subtype.

17 Oct 2017

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Scientists at Columbia's Zuckerman Institute today received a grant from the Chan Zuckerberg Initiative donor advised fund, an advised fund of the Silicon Valley Community Foundation, to construct an atlas of gene activity of all cells in the human spinal cord.

17 Oct 2017

Scientists discover new non-genetic cause of resistance to anti-cancer therapies

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States.

16 Oct 2017

Findings reveal how seizures can have lasting detrimental effects on memory

Although it's been clear that seizures are linked to memory loss and other cognitive deficits in patients with Alzheimer's disease, how this happens has been puzzling. In a study published in the journal Nature Medicine, a team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.

16 Oct 2017

CHLA and Keck Medicine of USC develop new liquid biopsy for tumor of the retina

Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age. If not diagnosed early, retinoblastoma may result in loss of one or both eyes and can be fatal. Unlike most cancers that are diagnosed using a biopsy, retinoblastoma tumors cannot be directly biopsied.

16 Oct 2017

Father's diet before sex could contribute to changes in the offspring’s health, study reveals

A new study, conducted by the University of Cincinnati (UC) biology professors Michal Polak and Joshua Benoit, suggests that a father's nutrition could play a similar role to the mother’s nutrition in his offspring’s health. Researchers from the University of Sydney's Charles Perkins Centre and the University of Western Australia also collaborated on the study.

16 Oct 2017

Einstein scientists share $9 million NIH grant for longevity research

Scientists now believe that the Fountain of Youth flows from our genes, or at least from the genes of people who live healthy lives to age 100 or later.

16 Oct 2017

Genes that determine skin color studied - new revelations

Human populations vary vastly in skin tones. European populations have been studied and some of the genes that determine skin color have been found. A latest study in a varied African population has found the specific and new genetic variants that could determine skin color and skin pigmentation. The study report is published in the journal Science.

16 Oct 2017

FDA advisory committee vote 16-0 for first even gene therapy for rare blindness

A panel of advisors to the United States Food and Drug Administration (FDA) has voted unanimously in favor of an experimental gene therapy to treat patients with a rare kind of hereditary blindness.

16 Oct 2017

Research aims to raise awareness of higher rate of testicular cancer in patients with DS

Research by Jue Wang, MD, at the University of Arizona Cancer Center at Dignity Health St. Joseph's Hospital and Medical Center on "Delay in Diagnosis of Testicular Cancer in a Patient with Down Syndrome" was published in the October issue of Journal of Cancer and Therapeutic Science.

13 Oct 2017

New study maps human genome to healthy tissue functions and disease processes

Our genomes help to determine who we are - the countless variations between individuals that encode the complexity of tissues and functions throughout the body.

13 Oct 2017

TGen awarded $2.5 million SU2C grant to test new method of treating pancreatic cancer

Stand Up To Cancer has awarded a $2.5 million SU2C CatalystR grant to the Translational Genomics Research Institute to investigate a revolutionary new method of treating pancreatic cancer, one of the most aggressive of all cancers.

13 Oct 2017

Study provides insights into potential causes of spinal stenosis

A new study published in the Journal of Orthopaedic Research indicates that certain genetic changes are linked with an increased risk of developing lumbar spinal stenosis, a narrowing of the open spaces in the lower spine that can lead to pain in the legs when individuals walk.

13 Oct 2017

Genetic News and Research

Arsenic trioxide could be powerful therapy to extend lives of certain glioblastoma patients

Genetic diversity plays major role in evolution of drug resistance

Study uses precision medicine approach to find effective treatments for rare cancers

Study sheds new light on why autism is more common in boys

Researchers identify strategies to mitigate disturbed axonal transport in ALS patients

Most ovarian cancers start in the fallopian tubes, study finds

Using AFM to study cell mechanics and function

Novel gene expression signature assay could help enhance lymphoma management

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Scientists discover new non-genetic cause of resistance to anti-cancer therapies

Findings reveal how seizures can have lasting detrimental effects on memory

CHLA and Keck Medicine of USC develop new liquid biopsy for tumor of the retina

Father's diet before sex could contribute to changes in the offspring’s health, study reveals

Einstein scientists share $9 million NIH grant for longevity research

Genes that determine skin color studied - new revelations

FDA advisory committee vote 16-0 for first even gene therapy for rare blindness

Research aims to raise awareness of higher rate of testicular cancer in patients with DS

New study maps human genome to healthy tissue functions and disease processes

TGen awarded $2.5 million SU2C grant to test new method of treating pancreatic cancer

Study provides insights into potential causes of spinal stenosis

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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