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The worst luck in the world? The heart disease mutation carried by 60 million

Heart disease is the number one killer in the world and India carries more than its share of this burden. Moreover, the problem is set to rise: it is predicted that by 2010 India's population will suffer approximately 60% of the world's heart disease.

19 Jan 2009

Researchers find novel use for old compound in cancer treatment

The compound, alpha-difluoromethylornithine or DFMO, targets the activity of a specific enzyme and, even in very limited doses, is effective in protecting against the malignancy in animal models.

19 Jan 2009

Researchers find essential proteins for final stage of malaria transmission cycle

Researchers at the Johns Hopkins Malaria Research Institute (JHMRI) have identified, for the first time, the molecular components that enable the malaria-causing parasite Plasmodium to infect the salivary glands of the Anopheles mosquito-a critical and final stage for spreading malaria to humans.

19 Jan 2009

New understanding on how aging causes broken bones to heal slowly

Researchers have unraveled crucial details of how aging causes broken bones to heal slowly, or not at all, according to study results published today in the Journal of Bone and Mineral Research.

19 Jan 2009

Discovery of potential new bactericide

As bacteria resistant to commonly used antibiotics continue to increase in number, scientists keep searching for new sources of drugs.

19 Jan 2009

Mutant host cell protein sequesters critical HIV-1 element

Scientists have identified a new way to inhibit a molecule that is critical for HIV pathogenesis.

19 Jan 2009

E. coli persists against antibiotics through HipA-induced dormancy

Bacteria hunker down and survive antibiotic attack when a protein flips a chemical switch that throws them into a dormant state until treatment abates, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan.16 edition of Science.

19 Jan 2009

Toxin-nanoparticle combo inhibits brain cancer invasion while imaging tumors

Working with a nanoparticle designed to target and image glioblastoma, a form of brain cancer, investigators at the University of Washington in Seattle have found that these same nanoparticles inhibit tumor cell invasion, one of the key events that leads to the metastatic spread of cancer. The investigators have also determined how the nanoparticles exert this potentially beneficial effect.

18 Jan 2009

Microfluidic devices capture and analyze single cancer cells

One of the grand goals in nanotechnology is to develop a single microfluidic device that integrates all of the components needed to perform polymerase chain reaction (PCR)-based nucleic acid analyses. Experts predict that such a device would enable researchers to develop rapid assays for cancer and other life-threatening diseases while a patient is in the doctor's office.

18 Jan 2009

Biodegradable nanoprobe images new blood vessel growth

Angiogenesis, the growth of new blood vessels, plays a critical role in several chronic human diseases, including metastatic cancer. In fact, several new anticancer therapies are designed to starve tumors by shutting down angiogenesis, but the lack of a good assay for quantifying angiogenesis in the body has hampered the development of effective antiangiogenesis therapies.

18 Jan 2009

Study shows how defective DNA repair triggers 2 neurological diseases

Scientists at St. Jude Children's Research Hospital have teased apart the biological details distinguishing two related neurological diseases-ataxia telangiectasia-like disease (ATLD) and Nijmegen breakage syndrome (NBS).

15 Jan 2009

Odors can alter gene expression in an olfactory neuron

New research from University of California, Davis, shows why a species of tiny worm can learn to ignore an odor – information that could have implications for how human memories are formed.

15 Jan 2009

Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers

The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders.

15 Jan 2009