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GATE complex discovery sheds light on CMV's evasion of immune defenses

New research from the University of Pittsburgh School of Medicine and La Jolla Institute for Immunology, published today in Nature Microbiology, reveals an opportunity for developing a therapy against cytomegalovirus (CMV), the leading infectious cause of birth defects in the United States.

30 Jun 2025

Study provides insights into the immune response following pig-to-human kidney xenotransplants

A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation.

30 Jun 2025

New yeast model sheds light on proteasome and mitochondrial interaction

A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating the interaction between the proteasome and mitochondrial function.

30 Jun 2025

Comprehensive study maps genetic mutations in SLC13A5 linked to epilepsy

Citrate is essential for the metabolism and development of neurons. A membrane transport protein called SLC13A5 plays a central role in this process and has previously been linked to a particularly severe form of epileptic encephalopathy.

30 Jun 2025

VIRMA protein regulates brain development by controlling ribosome biogenesis

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, multi-step process by which they are made.

30 Jun 2025

Gene therapy shows promise for reducing stroke risk in patients with sickle cell disease

Gene therapy for sickle cell disease may help improve a major contributing factor to stroke risk in patients, reports a new study from St. Jude Children's Research Hospital.

30 Jun 2025

Coffee’s hidden compounds could help fight type 2 diabetes

A comprehensive review of nearly 150 studies reveals that coffee polyphenols may help regulate blood sugar and reduce inflammation linked to type 2 diabetes. However, most evidence comes from preclinical research, and robust clinical trials are needed to confirm benefits.

29 Jun 2025

How 50,000 years of ancestry shaped India’s unique disease patterns

Scientists sequenced the genomes of 2,762 individuals across India, revealing the country’s unique ancestral makeup and a wealth of previously undocumented disease-related gene variants. The study highlights how ancient migrations, founder effects, and endogamy have shaped both diversity and disease risk in India.

29 Jun 2025

Discovery of a genetic dimmer switch controlling embryonic development

A team of scientists at the MRC Laboratory of Medical Sciences (LMS) has uncovered a previously unknown mechanism that controls how genes are switched ‘on’ and ‘off’ during embryonic development.

27 Jun 2025

Newly discovered target may re-energize exhausted immune cells in the fight against cancer

Van Andel Institute scientists and collaborators have discovered a potential treatment target that may re-energize dysfunctional or "exhausted" immune cells in their fight against cancer.

27 Jun 2025

Beetle-inspired tuberculosis testing device offers accurate detection for people with HIV

Current tuberculosis infection tests struggle to detect the disease in those with HIV. A common co-infection, HIV can hide TB from traditional tests by eliminating the immune cells relied upon to sound the alarm.

27 Jun 2025

PIEZO2 ion channel plays critical role in the formation of coronary vessels and the heart

The ion channel PIEZO2 doesn't just convey touch stimuli. It also plays a key role in the development of coronary vessels, a team led by Annette Hammes from the Max Delbrück Center reports in "Nature Cardiovascular Research."

27 Jun 2025

Blood test can reveal early signs of leukemia without bone marrow sampling

What if a blood test could reveal the pace of our aging – and the diseases that may lie ahead? The labs of Profs. Liran Shlush and Amos Tanay at the Weizmann Institute of Science have been conducting in-depth studies into the biology of blood to better understand the aging process and why some people become more susceptible to disease over the years.

27 Jun 2025

FAM111B identified as a key driver of glioma progression and therapeutic target

Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression.

27 Jun 2025

Proteome imbalance from aneuploidy linked to mitochondrial dysfunction

It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances.

27 Jun 2025

Reconstructing 50,000 thousand years of Indian ancestry using whole-genome data

India's population is genetically one of the most diverse in the world, yet it remains underrepresented in global datasets.

27 Jun 2025

Pesticides found to disrupt specific gut bacteria linked to inflammation

While emerging evidence suggests pesticides can be toxic to the mix of microorganisms in the digestive system, a new study is the first to map changes to specific gut bacteria based on interactions between human microbes and insect-killing chemicals observed in the lab and an animal model.

27 Jun 2025

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled "Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights."

27 Jun 2025

New 3D printed breast tissue model sheds light on milk production

Human breast milk is uniquely adapted to meet an infant's nutritional needs. Surprisingly, we still know very little about how milk is even made in the breast.

27 Jun 2025

Protein cleavage mechanism sheds light on severe childhood ciliopathies

New research by Sumeda Nandadasa, PhD, reveals how a key protein associated with Meckel-Gruber syndrome, nephronophthisis, Joubert syndrome and other ciliopathies is cut in half to perform two separate functions, both of which are fundamental to the healthy development of children.

27 Jun 2025