Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Long-term chronic bone loss occurs even after one time malaria infection

Malaria caused by Plasmodium parasites is a life-threatening infectious disease that kills at least half a million people annually while causing over 200 million new infections.

2 Jun 2017

Early study of experimental vaccine shows escalating immune response in patients with sarcoma

The critical component of an experimental vaccine led to an escalating immune response in patients with sarcoma, an indicator of its potential anti-cancer effects.

2 Jun 2017

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

A genetic variant that is particularly prevalent in people of African ancestry confers protection against malaria. LMU researchers have now shown how it modulates the properties of white blood cells that play a major role in immune defenses and inflammation.

1 Jun 2017

Researchers uncover new way to enhance function of immune cells to combat multiple myeloma

Researchers from Belgium led by Prof. Dirk Elewaut of the VIB-UGent Center for Inflammation Research and the team of Prof. Vanderkerken and Prof. Menu at the Hematology and Immunology lab of the VUB uncovered a new way to enhance the function of a specific type of immune cell that destroys tumors in multiple myeloma, a form of bone marrow cancer considered incurable.

1 Jun 2017

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

By adding an experimental drug to a standard chemotherapy regimen, a subset of patients with metastatic pancreatic cancer had a significantly longer period before the cancer progressed as compared with those who received the standard treatment, according to a Phase 2 clinical trial led by an investigator at Fred Hutchinson Cancer Research Center.

1 Jun 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

Many cancer patients' ED visits could be avoided with better symptom management, timely care

As many as 53 percent of cancer patients' Emergency Department visits that do not require admission could be avoided with better symptom management and greater availability of outpatient care tailored to their needs, according to a new study from Fred Hutchinson Cancer Research Center.

31 May 2017

Small clinical trial reveals promising results of triple immunotherapy in treating rare skin cancer

Three out of four patients treated with an experimental combination of three different therapies for the rare skin cancer known as Merkel cell carcinoma are in complete remission following the treatment, according to study results from a small clinical trial led at Fred Hutchinson Cancer Research Center.

31 May 2017

Investigational compound inhibits cancer-specific mutations in mice

Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell.

30 May 2017

New treatment strategies increase lifespan of transplanted kidneys

New treatment strategies over the last few decades have meant that nowadays 95% of transplanted kidneys function well for at least one year and that the average lifespan of a transplanted organ is between 10 and 15 years.

29 May 2017

New therapeutic approach could save diabetics from amputation by promoting wound healing

Diabetic patients frequently have lesions on their feet that are very difficult to heal due to poor blood circulation. In cases of serious non-healing infections, a decision to amputate could be made. A new therapeutic approach, presented recently in the Journal of Investigative Dermatology by Canadian researchers affiliated with the University of Montreal Hospital Research Centre, could prevent these complications by promoting wound healing.

29 May 2017

Study: Early-stage breast cancer patients undergo inappropriate tests that may increase financial burden

A study from Fred Hutchinson Cancer Research Center that will be presented at the American Society of Clinical Oncology annual meeting on June 5 in Chicago shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.

25 May 2017

Stem cell therapy using Helix transendocardial delivery system provides better results, study shows

BioCardia, Inc. today announced publication of a study in the International Heart Journal. According to the study, delivery of stem cell therapy to the heart using the Helix transendocardial delivery system results in superior cell delivery than either percutaneous intra-coronary infusion or direct injection in an open chest procedure.

24 May 2017

Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children's has opened the first clinical trial applying next-generation T-cell receptor sequencing and single-cell gene expression analysis to better understand how the immune system drives both inflammatory bowel disease in pediatric autoimmunity patients and graft-versus host disease in pediatric bone marrow transplant patients.

From 10x Genomics, Inc. 23 May 2017

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Immune diseases like multiple sclerosis and hemophagocytic lymphohistiocytosis unleash destructive waves of inflammation on the body, causing death or a lifetime of illness and physical impairment.

23 May 2017

Researchers show how DPF2 protein controls blood cell production in leukemia

Many things go wrong in cells during the development of cancer. At the heart of the chaos are often genetic switches that control the production of new cells.

23 May 2017

New discovery may be key to stopping shortages of vital blood-clotting cells

The emergency call issued by the American Red Cross earlier this year was of a sort all too common: Donations of platelets were needed, and desperately.

19 May 2017

Antibody drug conjugate could hold promise in improving treatment for childhood ALL

Researchers at The University of Manchester have discovered that a protein (5T4) found on the surface of cells contributes to chemotherapy resistance in the most common type of childhood leukaemia.

From The University of Manchester 19 May 2017

Exercising burns fat in bone marrow to improve bone health, study shows

It's a fat-burning secret anyone interested in bone health should know. For the first time, UNC School of Medicine researchers show that exercising burns the fat found within bone marrow and offers evidence that this process improves bone quality and the amount of bone in a matter of weeks.

18 May 2017

Researchers discover innovative way to produce hematopoietic stem cells

A study published on May 17 in Nature, discovers an innovative method to produce infinite supply of healthy blood cells from the readily available cells that line blood vessels. This achievement by the researchers at Weill Cornell Medicine marks the first time that any research group has generated such blood-forming stem cells.

18 May 2017

Bone Marrow News and Research

Further Reading

Long-term chronic bone loss occurs even after one time malaria infection

Early study of experimental vaccine shows escalating immune response in patients with sarcoma

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

Researchers uncover new way to enhance function of immune cells to combat multiple myeloma

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Many cancer patients' ED visits could be avoided with better symptom management, timely care

Small clinical trial reveals promising results of triple immunotherapy in treating rare skin cancer

Investigational compound inhibits cancer-specific mutations in mice

New treatment strategies increase lifespan of transplanted kidneys

New therapeutic approach could save diabetics from amputation by promoting wound healing

Study: Early-stage breast cancer patients undergo inappropriate tests that may increase financial burden

Stem cell therapy using Helix transendocardial delivery system provides better results, study shows

Seattle Children’s opens first clinical trial to study IBD and GVHD in pediatric patients

Experimental treatment tempers HLH, MS symptoms in mouse models, study shows

Researchers show how DPF2 protein controls blood cell production in leukemia

New discovery may be key to stopping shortages of vital blood-clotting cells

Antibody drug conjugate could hold promise in improving treatment for childhood ALL

Exercising burns fat in bone marrow to improve bone health, study shows

Researchers discover innovative way to produce hematopoietic stem cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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