Cell Nucleus News and Research

RSS

SRC-3 gene sends signal to cell membrane to promote cell motility

The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent growth of cancer cells by activating and encouraging the transcription of a genetic message into a protein, it also sends a signal to the cell membrane to promote cell motility or movement - a key element of cancer spread or metastasis, said Baylor College of Medicine (www.bcm.edu) researchers and collaborators in a report that appears in the current issue of the journal Molecular Cell.

15 Feb 2010

Histone modifications associated with pancreatic cancer development and progression

Specific chemical modifications to proteins called histones, which are found in the nucleus of cells and act as spools around which DNA is wound, can be used to predict prognosis and response to treatment in subsets patients with pancreatic cancer, a study by researchers at UCLA's Jonsson Comprehensive Cancer Center has found.

12 Feb 2010

Study may pave way for more refined treatments for brain tumors

Researchers at Washington University School of Medicine in St. Louis have shown once again that "ready, fire, aim," nonsensical though it may sound, can be an essential approach to research.

10 Feb 2010

NNK induces epigenetic alteration during cancer formation and inhibits tumor suppressor genes

In the history of humans fighting against cancer, the relationship between tobaccos and cancer has been an important subject for the academic and clinical research. By understanding the mechanism of why cancer is caused by tobaccos, scientists around the world all anticipate to solve the mystery of cancer and find the way of prevention and cure.

9 Feb 2010

Anomalies causing motivational deficiencies may also cause ADHD

Until now, attention-deficit/hyperactivity disorder (ADHD) was related to alterations in the brain affecting attention and cognitive processes. Researchers at Universitat Autònoma de Barcelona and the Vall d'Hebron University Hospital for the first time have discovered anomalies in the brain's reward system related to the neural circuits of motivation and gratification. In children with ADHD, the degree of motivation when carrying out an activity is related to the immediacy with which the objectives of the activity are met. This would explain why their attention and hyperactivity levels differ depending on the tasks being carried out.

4 Feb 2010

Researchers discover anomalies that cause lack of motivation in ADHD children

3 Feb 2010

Researchers find three different degenerative brain disorders linked by toxic form of Elk-1 protein

For the first time, researchers from the University of Pennsylvania School of Medicine have found that three different degenerative brain disorders are linked by a toxic form of the same protein. The protein, called Elk-1, was found in clumps of misshaped proteins that are the hallmarks of Parkinson's disease, Alzheimer's disease, and Huntington's disease.

3 Feb 2010

MSU scientist discovers the process that causes retinal cells to die

Scientists have long known that high blood sugar levels from diabetes damage blood vessels in the eye, but they didn't know why or how. Now a Michigan State University scientist has discovered the process that causes retinal cells to die, which could lead to new treatments that halt the damage.

2 Feb 2010

Blood flowing with force protects against dangerous clogs in blood vessels

It is second nature for most of us that exercise protects against heart attack and stroke, but researchers have spent 30 years unraveling the biochemistry behind the idea. One answer first offered by researchers at the University of Rochester Medical Center is that athletic hearts push blood through arteries with greater force, which alone triggers reactions that protect against dangerous clogs in blood vessels.

29 Jan 2010

Researchers challenge prevailing belief about role of protein in abnormal cell proliferation

In a study to be published this week, a research team is challenging a prevailing belief about the behavior of a human protein linked to the formation of cancer, possibly breathing new life into the search for therapies that will inhibit that protein from "turning on" genes involved in abnormal cell proliferation.

27 Jan 2010

Discovery challenges understanding of blood cell development

University of Utah researchers led an international team of scientists that is the first to report on the previously undescribed ability of platelets to reproduce themselves in the circulation. Their revolutionary findings were published online Jan. 19, 2010, in the journal Blood.

27 Jan 2010

Scott & White conducts DBS research for Parkinson's patients

At Scott & White Memorial Hospital, a multi-disciplinary team of neurosurgeons, neurologists, neurophysiologist, neuropsychologists and a movement disorders specialist are offering hope to some Parkinson's patients with a treatment called Deep Brain Stimulation (DBS). DBS involves placing a thin wire that carries electrical currents deep within the brain on Parkinson's patients who are no longer benefitting from medications, and have significant uncontrollable body movements called dyskinesia. Scott & White is also performing research into the effects of DBS on the non-motor symptoms of Parkinson's disease including "drenching sweats," bladder dysfunction, depression, hallucination, anxiety, and dementia as well as intestinal disorders, loss of sense of smell, and sleep disturbances.

27 Jan 2010

Testing DBS for treating severe long-term depression

Bewernick and colleagues administered DBS treatment in ten patients with severe long-term depression who had not responded to multiple other antidepressant treatments, including psychotherapy, drug treatments and electroconvulsive treatment. After one year of DBS, all patients showed some improvement, and half of them experienced significant improvement in their symptoms of depression, astonishing considering they had not responded to any prior antidepressant treatment. In addition, the patients showed reduced ratings of anxiety and had only minor side effects. Importantly, none of their overall brain functioning was impaired by the DBS treatment.

27 Jan 2010

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

Research on the genetic defect that causes myotonic muscular dystrophy has revealed that the mutation disrupts an array of metabolic pathways in muscle cells through its effects on two key proteins.

24 Jan 2010

Study indicates size of brain structures may predict performance and learning rates

Researchers can predict your performance on a video game simply by measuring the volume of specific structures in your brain, a multi-institutional team reports this week.

21 Jan 2010

Top pharmaceutical companies choose Cegedim Dendrite's cMDM solution

Cegedim Dendrite today announced that four prominent Life Sciences companies have contracted for its Customer Master Data Management (cMDM) solution, Nucleus as a Service, within the last four months. Three of the four are among the world’s top-25 pharmaceutical companies and the fourth is a mid-sized specialty pharmaceutical company. Cegedim Dendrite is the leading provider of Customer Relationship Management (CRM), Marketing, Regulatory Compliance and Data Optimization solutions designed specifically for the Life Sciences industry.

19 Jan 2010

Scientists discover new mechanism that explains role of EBV in tumor growth

The Epstein-Barr virus (EBV), a virus of the herpes family, has two distinct life phases: After infecting a cell it first goes into a resting phase. Under certain circumstances the virus can become active - and then induces tumor growth or promotes its synthesis in the cell.

18 Jan 2010

GIND scientists identify major role of TDP-43 in two neurodegenerative diseases

Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified the reason a key protein plays a major role in two neurodegenerative diseases.

13 Jan 2010

YM BioSciences announces results of cancer antibody-radionuclide conjugate development collaboration

YM BioSciences Inc. today announced results of a collaboration with researchers at the University of Toronto for the development of highly potent antibody-radionuclide conjugates for use in the treatment of cancer. The approach has successfully concluded its first series of proof-of-principle experiments establishing promise for future development and application.

12 Jan 2010

Gene therapy may help correct molecular flaws that cause brain disease

Neuroscientists have forged an unlikely molecular union as part of their fight against diseases of the brain and nervous system.

9 Jan 2010

Cell Nucleus News and Research

SRC-3 gene sends signal to cell membrane to promote cell motility

Histone modifications associated with pancreatic cancer development and progression

Study may pave way for more refined treatments for brain tumors

NNK induces epigenetic alteration during cancer formation and inhibits tumor suppressor genes

Anomalies causing motivational deficiencies may also cause ADHD

Researchers discover anomalies that cause lack of motivation in ADHD children

Researchers find three different degenerative brain disorders linked by toxic form of Elk-1 protein

MSU scientist discovers the process that causes retinal cells to die

Blood flowing with force protects against dangerous clogs in blood vessels

Researchers challenge prevailing belief about role of protein in abnormal cell proliferation

Discovery challenges understanding of blood cell development

Scott & White conducts DBS research for Parkinson's patients

Testing DBS for treating severe long-term depression

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

Study indicates size of brain structures may predict performance and learning rates

Top pharmaceutical companies choose Cegedim Dendrite's cMDM solution

Scientists discover new mechanism that explains role of EBV in tumor growth

GIND scientists identify major role of TDP-43 in two neurodegenerative diseases

YM BioSciences announces results of cancer antibody-radionuclide conjugate development collaboration

Gene therapy may help correct molecular flaws that cause brain disease

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

Latest News