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Mild exercise habits during development could prevent schizophrenia, study reveals

Although schizophrenia is increasingly understood as a neurodevelopmental disorder, environmental factors are known to play an important role in the disease onset and progression.

16 Dec 2020

Study provides valuable interaction about animal host and pathogen during pneumococcal infections

Researchers at the University of Maryland School of Medicine published one of the most comprehensive analyses of how genes get expressed during infection (known as a transcriptome). The analyses include three different strains of the bacteria Streptococcus pneumoniae, which causes pneumonia, meningitis, and middle-ear infections.

15 Dec 2020

Microglial surveillance helps prevent seizure activity in the brain

An important part of the brain's immune system, cells called microglia constantly extend and retract "branches" from their cell body to survey their environment.

14 Dec 2020

Study unlocks some muscle cell secrets

A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are.

11 Dec 2020

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

"Wet" age-related macular degeneration (AMD) is one of the most common causes of irreversible vision loss in the elderly, and it occurs when abnormal and leaky blood vessels form in the retina, in part due to inflammation.

11 Dec 2020

Scientist pinpoints genes that promote the growth of prostate cancer cells

Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.

11 Dec 2020

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Most autism spectrum disorders have a complex, multifactorial genetic component, making it difficult to find specific treatments. Rett syndrome is an exception.

9 Dec 2020

Reductive stress promotes protein aggregation in neuroblastoma cells, impairs neurogenesis

Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress, or RS -- may affect neurons.

8 Dec 2020

Mice study shows how COVID-19 damages organs other than the lungs

UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs.

8 Dec 2020

Research team develops a new decoding method for viral genes

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

7 Dec 2020

Drug prescribed for rare enzyme deficiency shows promise to treat herpes viruses

A drug currently prescribed to treat a rare enzyme deficiency can help cells clear the herpes simplex 1 and herpes simplex 2 viruses, according to a new study published in the journal Science Advances.

7 Dec 2020

Chronic sleep disruption can lead to depression in adolescents, study shows

Chronic sleep disruption during adolescence can lead to depression in both males and females and alters stress reactivity in females, according to a new study led by University of Ottawa researchers.

7 Dec 2020

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

The COVID-19 pandemic is showing a strong comeback after an initial reduction in the number of cases, following energetic public health interventions.

7 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

Genetically engineered T cells can target, attack pathogenic T cells that cause Type 1 diabetes

A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.

3 Dec 2020

Scientists identify mechanisms behind inflammasome activation by fungal pathogens

Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus.

2 Dec 2020

A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

Study: Maternal omega-3 deficiency can alter the development of neuronal networks in offspring

Omega-3 fatty acids are essential, necessarily supplied by the diet and indispensable to brain development.

2 Dec 2020

Repurposed mouse model sheds light on spectrum of COVID-19 disease symptoms

A repurposed mouse model can develop symptoms of both severe COVID-19 (lung damage, blood clots, abnormal blood vessels, and death) and also of milder disease, including loss of the sense of smell, according to a recent University of Iowa study published in Nature.

1 Dec 2020

Study uncovers a promising therapeutic target for retinal dystrophies

A team of LSU Health New Orleans researchers reports for the first time that deleting one of the inhibitors of the RPE65 gene in a mouse model that carries a human disease mutation prevents degeneration of cone photoreceptors that are used for daytime high-resolution color vision.

1 Dec 2020

Mouse Model News and Research

Mild exercise habits during development could prevent schizophrenia, study reveals

Study provides valuable interaction about animal host and pathogen during pneumococcal infections

Microglial surveillance helps prevent seizure activity in the brain

Study unlocks some muscle cell secrets

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

Scientist pinpoints genes that promote the growth of prostate cancer cells

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Reductive stress promotes protein aggregation in neuroblastoma cells, impairs neurogenesis

Mice study shows how COVID-19 damages organs other than the lungs

Research team develops a new decoding method for viral genes

Drug prescribed for rare enzyme deficiency shows promise to treat herpes viruses

Chronic sleep disruption can lead to depression in adolescents, study shows

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

Findings about primary cilia may be relevant for transplantation therapies in diabetes

Genetically engineered T cells can target, attack pathogenic T cells that cause Type 1 diabetes

Scientists identify mechanisms behind inflammasome activation by fungal pathogens

A new potential COVID-19 vaccine candidate: YF-S0

Study: Maternal omega-3 deficiency can alter the development of neuronal networks in offspring

Repurposed mouse model sheds light on spectrum of COVID-19 disease symptoms

Study uncovers a promising therapeutic target for retinal dystrophies

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