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Scientists engineer potent trivalent inhibitors of thrombin

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient.

29 Jan 2021

Researchers identify new strategy to protect offspring from prenatal stress

New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.

29 Jan 2021

Researchers figure out how the immune system keeps tabs on the brain

Alzheimer's disease, multiple sclerosis, autism, schizophrenia and many other neurological and psychiatric conditions have been linked to inflammation in the brain.

27 Jan 2021

Vaccines delivered via skin may offer better protection against respiratory diseases

Among infectious diseases that have caused pandemics and epidemics, smallpox stands out as a success story. Smallpox vaccination led to the disease's eradication in the twentieth century.

27 Jan 2021

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity.

27 Jan 2021

Genetic interactions may shed light on NGLY1 deficiency

In 2012, four-year-old Bertrand Might became the first-ever patient diagnosed with a rare genetic disorder called N-glycanase (NGLY1) deficiency. The discovery of this condition and Bertrand's diagnosis allowed doctors to look for other children with the same genetic defect. Since then, more than 60 additional patients have been found.

26 Jan 2021

George Mason researchers investigating COVID-19 therapies

Yuntao Wu, Professor, Molecular and Microbiology, and Ramin Hakami, Associate Professor, School of Systems Biology, are conducting studies of COVID-19 therapies.

22 Jan 2021

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'.

22 Jan 2021

Researchers use SARS-CoV-2 to bioengineer universal vaccine platform

Using SARS-CoV-2, a team of scientists from the United States has recently developed a bioengineered bacteriophage T4 nanoparticle structure using CRISPR technology that can be used as a universal platform to produce vaccines.

21 Jan 2021

Nicotine promotes breast cancer lung metastasis, finds study

Breast cancer is the second most common cancer among women in the United States, and cigarette smoking is associated with a higher incidence of breast cancer spread, or metastasis, lowering the survival rate by 33% at diagnosis.

21 Jan 2021

Eliminating key gene could revive exhausted immune cells to battle solid tumors

Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests.

20 Jan 2021

BMP5/7 protein offers promising therapeutics that could halt the progression of Parkinson's disease

Ben-Gurion University of the Negev researchers have discovered that the protein BMP5/7 offers promising therapeutics that could slow down or halt the progression of Parkinson's disease.

20 Jan 2021

Inflammation may contribute to the persistence of C. diff infection, shows study

A new study from North Carolina State University shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.

19 Jan 2021

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

The potentially deadly COVID-19 has not affected animals with corresponding severity. To understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new study indicates that this may not be a faithful model of human lethal infection with SARS-CoV-2.

18 Jan 2021

Study reveals new way to target cancer’s nutritional needs

Scientists discover a way to target cancer’s nutritional needs, which could lead to a new way to treat the disease, according to a study published in Nature Communications today (Thursday).

18 Jan 2021

Study shows why antihistamine drugs fail to control severe itch in eczema patients

In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that itching can become torturous. Worse, antihistamines -- the standard treatment for itching and allergy -- often don't help.

15 Jan 2021

Study may help develop more effective personalized immunotherapy for cancer patients

New research from CU Cancer Center member Jing Hong Wang, MD, PhD, and recent University of Colorado Immunology program graduate Rachel Woolaver, PhD, may help researchers develop more effective personalized immunotherapy for cancer patients.

15 Jan 2021

Specific brain neurons could provide a target for treating sleep-related disorders

We laugh when we see Homer Simpson falling asleep while driving, while in church, and while even operating the nuclear reactor. In reality though, narcolepsy, cataplexy, and rapid eye movement (REM) sleep behavior disorder are all serious sleep-related illnesses.

14 Jan 2021

Novel compound appears to protect myelin and nerve fibers

A compound developed at Oregon Health & Science University appears to protect nerve fibers and the fatty sheath, called myelin, that covers nerve cells in the brain and spinal cord.

13 Jan 2021

Study reveals cardiac protein as a new target for different types of heart disease

Like a failing fuel pump that causes a loss of engine power in a car, a diseased heart can take a serious toll on the body's performance. For some patients, tasks like walking up a flight of stairs or walking across a room eventually turn into exhausting endeavors.

13 Jan 2021

Mouse Model News and Research

Scientists engineer potent trivalent inhibitors of thrombin

Researchers identify new strategy to protect offspring from prenatal stress

Researchers figure out how the immune system keeps tabs on the brain

Vaccines delivered via skin may offer better protection against respiratory diseases

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Genetic interactions may shed light on NGLY1 deficiency

George Mason researchers investigating COVID-19 therapies

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

Researchers use SARS-CoV-2 to bioengineer universal vaccine platform

Nicotine promotes breast cancer lung metastasis, finds study

Eliminating key gene could revive exhausted immune cells to battle solid tumors

BMP5/7 protein offers promising therapeutics that could halt the progression of Parkinson's disease

Inflammation may contribute to the persistence of C. diff infection, shows study

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

Study reveals new way to target cancer’s nutritional needs

Study shows why antihistamine drugs fail to control severe itch in eczema patients

Study may help develop more effective personalized immunotherapy for cancer patients

Specific brain neurons could provide a target for treating sleep-related disorders

Novel compound appears to protect myelin and nerve fibers

Study reveals cardiac protein as a new target for different types of heart disease

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