Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

New clinical trial to evaluate efficacy of stem cell product in patients disabled with chronic stroke

A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston.

16 May 2017

Stem cell treatment helps improve motor functions, nervous system conditions in mice with ALS

Researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to the blood-spinal cord barrier.

15 May 2017

New technology could hold key to predicting outcome of blood cancer patients

Technology that can detect the length of small DNA structures in cancer cells could hold the key to predicting the outcome of patients with two different types of blood cancer.

11 May 2017

UT Health scientists discover epigenetic changes that contribute to AML

UT Health San Antonio researchers discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow.

10 May 2017

Mothers infected with malaria during pregnancy can alter infants’ immunity

Mothers infected with malaria during pregnancy can pass more of their own cells to their baby and change the infant's risk of later infection, a new study shows.

9 May 2017

Vitamin A deficiency leads to loss of blood stem cells

Many specialized cells, such as in the skin, gut or blood, have a lifespan of only a few days. Therefore, steady replenishment of these cells is indispensable. They arise from so-called "adult" stem cells that divide continuously.

5 May 2017

FDA approves new AML drug after clinical testing at Dana-Farber

A targeted drug whose clinical testing was led by Richard Stone, MD, of Dana-Farber Cancer Institute, has become the first new treatment for newly diagnosed acute myeloid leukemia (AML) in more than 25 years.

5 May 2017

Dendritic cells develop from specialized progenitors, research shows

Dendritic cells are gatekeepers of Immunity and are crucial for the detection and initiation of Immunity against pathogens and foreign substances. Up to now dendritic cell subtypes were thought to develop from one common progenitor.

5 May 2017

Phagocytosis educates the immune system

Phagocytosis is a biological mechanism whereby specialized cells ingest and degrade old, dead, or damaged cells to prevent tissue damage due to their accumulation.

4 May 2017

New treatment offers hope for kidney failure and transplant patients with rare disorder

A novel treatment offers kidney failure and kidney transplant patients with a rare disorder new hope. The treatment allows targeted elimination of plasma cell clones producing abnormal proteins that deposits in the kidneys and leads to kidney failure, according to new research.

3 May 2017

Study suggests how existing and emerging immunotherapy treatments could be successful for sarcomas

Sarcomas- cancers of the connective tissues like muscles, joints, fat and bone - come in dozens of subtypes. Clinical trial results have been mixed when treating these diverse tumors with immunotherapy, a targeted therapeutic strategy that has success in other cancers.

3 May 2017

FDA approves new drug and chemotherapy combination for treatment of adult patients with AML

The U.S. Food and Drug Administration today approved Rydapt (midostaurin) for the treatment of adult patients with newly diagnosed acute myeloid leukemia who have a specific genetic mutation called FLT3, in combination with chemotherapy.

28 Apr 2017

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Cellular therapy hasn't had much success in fighting solid tumors, partly because it's been difficult to deliver anti-cancer T cells to the tumors.

25 Apr 2017

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body.

21 Apr 2017

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Through experimental work, an international team of researchers led by City of Hope's Defu Zeng, professor of diabetes immunology and hematopoietic cell transplantation, believe they may have found a way to prevent graft-versus-host disease after stem cell transplants while retaining the transplants' positive effects on fighting leukemia and lymphoma.

18 Apr 2017

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ("good" fat) by employing two receptors on BAT cells as potential therapeutic targets.

17 Apr 2017

Nanoparticle-programmed immune cells can slow progression of leukemia in mouse model

Researchers at Fred Hutchinson Cancer Research Center have developed biodegradable nanoparticles that can be used to genetically program immune cells to recognize and destroy cancer cells -- while the immune cells are still inside the body.

17 Apr 2017

Discovery of additional viral reservoir reveals new target for HIV cure research

HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system.

17 Apr 2017

International research effort reveals major insights into spread of West African Ebola epidemic

An international effort to analyze the entire database of Ebola virus genomes from the 2013-2016 West African epidemic reveals insights into factors that sped or slowed the rampage and calls for using real-time sequencing and data-sharing to contain future viral disease outbreaks.

12 Apr 2017

Bone Marrow News and Research

Further Reading

New clinical trial to evaluate efficacy of stem cell product in patients disabled with chronic stroke

Stem cell treatment helps improve motor functions, nervous system conditions in mice with ALS

New technology could hold key to predicting outcome of blood cancer patients

UT Health scientists discover epigenetic changes that contribute to AML

Mothers infected with malaria during pregnancy can alter infants’ immunity

Vitamin A deficiency leads to loss of blood stem cells

FDA approves new AML drug after clinical testing at Dana-Farber

Dendritic cells develop from specialized progenitors, research shows

Phagocytosis educates the immune system

New treatment offers hope for kidney failure and transplant patients with rare disorder

Study suggests how existing and emerging immunotherapy treatments could be successful for sarcomas

FDA approves new drug and chemotherapy combination for treatment of adult patients with AML

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

Nanoparticle-programmed immune cells can slow progression of leukemia in mouse model

Discovery of additional viral reservoir reveals new target for HIV cure research

International research effort reveals major insights into spread of West African Ebola epidemic

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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