Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Scientists gain new insights into how cancer cells may squeeze through narrow blood vessels

The spread of cancer from a tumor's original location to other parts of the body can play a major role in whether the disease turns deadly. Many steps in this process, called metastasis, remain murky.

30 Jun 2016

Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

One of the first clues pathologists look for in tissue from a newly diagnosed breast cancer patient is the estrogen receptor, a nuclear protein that converts hormonal messages in the bloodstream into instructions for the cell about how to behave

24 Jun 2016

New insights into cancer cell signaling could help prevent metastases

Research published yesterday in Nature Communications has revealed a previously unknown mechanism by which metastasising cancer cells survive when they break away from the primary tumour. It is hoped that the discovery could help with the development of novel cancer treatments that prevent metastasis.

24 Jun 2016

Researchers reveal integrins could be key to survival mechanism in cancer cells

Cancer cells appear to depend on an unusual survival mechanism to spread around the body, according to an early study led by Queen Mary University of London. The discovery could help with future development of novel treatments to prevent metastasis and secondary tumours.

24 Jun 2016

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

A team led by researchers at St. Jude Children's Research Hospital report that mice lacking the protein Alix develop hydrocephalus or "water on the brain." Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the epithelial barrier.

23 Jun 2016

Pretreatment smoking linked to poor prognosis in AI-treated patients

Among older aromatase inhibitor (AI)-treated patients with breast cancer, current smokers at treatment initiation have an increased risk of breast cancer events and distant metastases, say Swedish researchers.

23 Jun 2016

Potential therapeutic approaches to combat chronic myeloid leukemia

Chronic myeloid leukemia (CML) develops through chromosomal alterations in blood-forming cells of the bone marrow and usually occurs in older persons. Around 20 percent of adults diagnosed with leukemia suffer from this type of blood cancer.

21 Jun 2016

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

17 Jun 2016

Researchers reveal how cancer cells use energy to move and divide so quickly

Cancer cells and normal cells both divide and move, but with cancer cells it's like they're on steroids: everything is bigger, faster, more.

15 Jun 2016

EPFL researchers reprogram TAMs to prevent tumor metastasis

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis.

14 Jun 2016

Study opens up new strategy to make immunotherapy more effective for different cancer types

By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.

14 Jun 2016

Lack of signaling protein CXCR4 may halt cancer development

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties.

10 Jun 2016

Intrinsic subtyping of breast cancer can aid prognosis, treatment of tumor patients

Published in JAMA Oncology, Principal Investigator of Vall d´Hebron Institute of Oncology´s Translational Genomics Group, Team Leader of translational genomics and targeted therapeutics in solid tumors at the August Pi I Sunyer Biomedical Research Institute, and Head of Medical Oncology at the Hospital Clínic in Barcelona, Aleix Prat has led a study showing the intrinsic subtyping of breast cancer by means of a genomic test as the most important prognostic factor in advanced or metastatic hormone-sensitive breast cancer.

10 Jun 2016

UCLA scientists develop statistical method for conducting survival analysis of cancer patients

People with cancer are often told by their doctors approximately how long they have to live, and how well they will respond to treatments, but what if there were a way to improve the accuracy of doctors' predictions?

9 Jun 2016

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Professor Claudio Luchinat, University of Florence and co-founder of the Magnetic Resonance Center (CERM), speaks to News-Medical about his research in NMR-based metabolomics.

From Bruker BioSpin Group 9 Jun 2016

Researchers identify promising new compound for targeting triple-negative breast cancer

Researchers at the University of Michigan have identified a promising new compound for targeting one of the most aggressive types of breast cancer.

9 Jun 2016

New mathematical model helps examine metabolism of breast epithelium

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling. This research, published in PLOS Computational Biology, may contribute to the development of cell specific anti-cancer interventions.

8 Jun 2016

NaF-PET/CT scans can accurately detect bone metastases in advanced prostate cancer patients

A recent pilot study reported in the June issue of The Journal of Nuclear Medicine found that sodium fluoride (Na-F-18) positron emission tomography/computed tomography (NaF-PET/CT) accurately detects bone metastases in patients with advanced prostate cancer, and follow-up scans over time correlate clearly with clinical outcomes and patient survival.

8 Jun 2016

New clinical study data could redefine treatment for mCRPC patients

Janssen-Cilag International NV today announced that data from an interim analysis of The Prostate Cancer Registry, Europe’s first and largest prospective study of men with metastatic castration-resistant prostate cancer (mCRPC), indicate that the presence of distant metastases (M1) at initial diagnosis may be a critical indicator of future treatment and prognosis for mCRPC patients.

7 Jun 2016

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens.

7 Jun 2016

Metastasis News and Research

Further Reading

Scientists gain new insights into how cancer cells may squeeze through narrow blood vessels

Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

New insights into cancer cell signaling could help prevent metastases

Researchers reveal integrins could be key to survival mechanism in cancer cells

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

Pretreatment smoking linked to poor prognosis in AI-treated patients

Potential therapeutic approaches to combat chronic myeloid leukemia

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers reveal how cancer cells use energy to move and divide so quickly

EPFL researchers reprogram TAMs to prevent tumor metastasis

Study opens up new strategy to make immunotherapy more effective for different cancer types

Lack of signaling protein CXCR4 may halt cancer development

Intrinsic subtyping of breast cancer can aid prognosis, treatment of tumor patients

UCLA scientists develop statistical method for conducting survival analysis of cancer patients

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Researchers identify promising new compound for targeting triple-negative breast cancer

New mathematical model helps examine metabolism of breast epithelium

NaF-PET/CT scans can accurately detect bone metastases in advanced prostate cancer patients

New clinical study data could redefine treatment for mCRPC patients

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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