Mouse Model News and Research

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Cancer-killing virus developed at City of Hope activates the immune system against colon cancer

City of Hope scientists have developed a cancer-killing virus by combining the oncolytic virus CF33 with an immune checkpoint inhibitor.

1 Dec 2020

Adding exercise to genetic treatment reverses fatigue in mice with common myotonic dystrophy

Adding exercise to a genetic treatment for myotonic dystrophy type 1 (DM1) was more effective at reversing fatigue than administering the treatment alone in a study using a mouse model of the disease.

30 Nov 2020

Penn study opens the door to let CAR T cells reach the tumor microenvironment

The labyrinth of jumbled blood vessels in the tumor microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumors.

30 Nov 2020

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Monoclonal antibody HB27 shows potent neutralizing activity against SARS-CoV-2

A new study reports a very promising anti-SARS-CoV-2 monoclonal antibody, HB27, that appears to have two distinct mechanisms of action inhibiting the virus-host cell interaction and subsequent infection.

27 Nov 2020

Transgenic mouse model could recapitulate severe COVID-19 in humans

Researchers in the United States and Canada have described the potential for a transgenic mouse model to serve as an effective platform for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe disease course in humans.

26 Nov 2020

Dexamethasone use could reduce immune checkpoint inhibitor efficacy in glioblastoma patients

Bottom Line: Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival.

25 Nov 2020

Copper isotopes can help detect Alzheimer's aggregates in the brain

A proof-of-concept study conducted in a mouse model of Alzheimer's disease offers new evidence that copper isotopes can be used to detect the amyloid-beta protein deposits that form in the brains of people living with - or at risk of developing - Alzheimer's.

25 Nov 2020

New drug lures stem cells to damaged tissue, improves treatment efficacy

Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine.

25 Nov 2020

Potential treatment could reduce heart failure after a significant heart attack

While there are therapies to aid in overall heart health, there are very few preventative therapies for heart failure after a significant heart attack, a serious condition that has a very significant mortality.

24 Nov 2020

Study shows how rotavirus leads to severe gastrointestinal disease

Rotavirus is a major cause of diarrhea and vomiting, especially in children, that results in approximately 128,000 deaths annually.

20 Nov 2020

Researchers identify CLCN6 as disease gene for severe lysosomal neurodegenerative disorder

A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie and the Max Delbrück Center für Molekulare Medizin, together with an international team of researchers, have now analyzed the effect of a point mutation that was found in three unrelated affected children.

19 Nov 2020

Study sheds new light on how diabetes contributes to the development of Alzheimer’s disease

New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer's disease.

18 Nov 2020

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

De'Broski Herbert has a philosophy that's guided his career researching helminths, or parasitic worms, and their interaction with their hosts' immune systems: "Follow the worm."

15 Nov 2020

SARS-CoV-2-induces temporary loss of smell in mice

Now, a new study published on the preprint server bioRxiv in November 2020 presents the onset of olfactory dysfunction (loss of smell) in mice infected with the virus, examining this process at the cellular level. In doing so, this study throws more light on this curious symptom and COVID-19’s manifestations outside the lungs.

12 Nov 2020

Researchers find a better way to block asthma triggers

Every day, ten Americans die from asthma. While quick-acting inhalers and medications can reduce inflammation during an asthma attack, people with asthma have few tools to prevent the next attack from coming.

11 Nov 2020

Microbes in the lungs could influence lung cancer progression and prognosis

Bottom Line: Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer.

11 Nov 2020

Gene signature may help develop new therapies against advanced prostate cancer

Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to spread, or metastasize, early in the course of the disease and whether it will respond to anti-androgen therapy, a common treatment for advanced disease.

11 Nov 2020

Dietary induction of hepatocyte regeneration may be a viable strategy to enhance gene repair

Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver.

11 Nov 2020

A new method to improve the preclinical evaluation of CAR T cell therapies

Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment.

6 Nov 2020

Mouse Model News and Research

Cancer-killing virus developed at City of Hope activates the immune system against colon cancer

Adding exercise to genetic treatment reverses fatigue in mice with common myotonic dystrophy

Penn study opens the door to let CAR T cells reach the tumor microenvironment

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

Monoclonal antibody HB27 shows potent neutralizing activity against SARS-CoV-2

Transgenic mouse model could recapitulate severe COVID-19 in humans

Dexamethasone use could reduce immune checkpoint inhibitor efficacy in glioblastoma patients

Copper isotopes can help detect Alzheimer's aggregates in the brain

New drug lures stem cells to damaged tissue, improves treatment efficacy

Potential treatment could reduce heart failure after a significant heart attack

Study shows how rotavirus leads to severe gastrointestinal disease

Researchers identify CLCN6 as disease gene for severe lysosomal neurodegenerative disorder

Study sheds new light on how diabetes contributes to the development of Alzheimer’s disease

Study reveals key role of IL-33 signaling molecule in parasite infections, other health conditions

SARS-CoV-2-induces temporary loss of smell in mice

Researchers find a better way to block asthma triggers

Microbes in the lungs could influence lung cancer progression and prognosis

Gene signature may help develop new therapies against advanced prostate cancer

Dietary induction of hepatocyte regeneration may be a viable strategy to enhance gene repair

A new method to improve the preclinical evaluation of CAR T cell therapies

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