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Some stem cells take charge of their surroundings

Adult stem cells are not pampered pushovers. O'Reilly et al. report that certain stem cells take charge of their surroundings, molding their environment to control their division and differentiation.

25 Aug 2008

NicOx updates on PF-03187207 and research collaboration with Pfizer

NicOx S.A. has announced the results of a dose-ranging phase 2 study conducted with PF‑03187207 in Japanese patients with glaucoma by its partner Pfizer Inc. PF-03187207 is a nitric oxide-donating prostaglandin analog. The study was designed to compare the safety and efficacy of several doses of PF-03187207 to Xalatan (latanoprost) and enrolled 112 Japanese patients with primary open-angle glaucoma or ocular hypertension.

25 Aug 2008

Study reveals how blood flow force protects against atherosclerosis

Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. By sensing and reacting to force, such machines interfere with inflammatory pathways central to atherosclerosis, the cause of clogged arteries that lead to heart attack and stroke, the authors said. The next set of studies, already underway, seeks to "tweak" the process with the goal of designing a new class of therapies.

25 Aug 2008

OncoGenex Pharmaceuticals' OGX-011 granted FDA fast track status

OncoGenex Pharmaceuticals has announced that OGX-011, also known as custirsen sodium, received Fast Track designation from the U.S. Food & Drug Administration (FDA) in combination with docetaxel for progressive metastatic prostate cancer.

24 Aug 2008

Researchers discover key details of how rheumatoid arthritis destroys bone

Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry. The findings are already guiding attempts to design new drugs to reverse RA-related bone loss and may also address more common forms of osteoporosis with a few adjustments.

24 Aug 2008

Malaria researchers discover new mosquito virus

Researchers at the Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute have identified a previously unknown virus that is infectious to Anopheles gambiae-the mosquito primarily responsible for transmitting malaria.

24 Aug 2008

Australian scientist finds the key to overeating as we age

A Monash University scientist has discovered key appetite control cells in the human brain degenerate over time, causing increased hunger and potentially weight-gain as we grow older.

21 Aug 2008

ICMT enzyme shows potential as target in treating blood cancer

A discovery by a research team with the Sahlgrenska Academy at Gothenburg University in Sweden may lead to new treatments for blood cancer and other diseases. By stopping the production of a specific enzyme, ICMT, researchers were able to alleviate disease symptoms in mice with blood cancer.

21 Aug 2008

New discovery on how rheumatoid arthritis destroys bone

20 Aug 2008

Eli Lilly acquires SGX Pharmaceuticals

Eli Lilly and Company has announced that it has completed the acquisition of SGX Pharmaceuticals, Inc. (Public, NASDAQ:SGXP), a San Diego-based biotechnology company focused on drug discovery and development in the area of oncology.

20 Aug 2008

Simple bowel cancer test spots deadliest tumours

British scientists say a simple bowel cancer test could save thousands of lives by spotting the deadliest tumours.

20 Aug 2008

Scientists discover how mutation in the copper-regulating protein ATP7B causes Wilson disease

Using a combination of computer simulations and cutting-edge lab experiments, physical biochemists at Rice University have discovered how a small genetic mutation -- which is known to cause Wilson disease -- subtly changes the structure of a large, complex protein that the body uses to keep copper from building up to toxic levels.

19 Aug 2008

Evolution in the ribosome

A new study of the ribosome, the cell's protein-building machinery, sheds light on the oldest branches of the evolutionary tree of life and suggests that differences in ribosomal structure between the three main branches of that tree are "molecular fossils" of the early evolution of protein synthesis.

18 Aug 2008

Scientists discover platelets play an important early role in promoting cerebral malaria

Platelets - those tiny, unassuming cells that cause blood to clot and scabs to form when you cut yourself - play an important early role in promoting cerebral malaria, an often lethal complication that occurs mostly in children.

18 Aug 2008

First drug for Huntington's disease approved for use in the U.S.

Huntington's disease is a fatal, inherited neurodegenerative disorder for which there is no cure and usually affects people in their 30s and 40s, but some patients are affected as early as childhood, while others aren't affected until they are older.

18 Aug 2008

Researchers uncover attack mechanism of illness-inducing bacterium found in shellfish

An infectious ocean-dwelling bacterium found in oysters and other shellfish kills its host's cells by causing them to burst, providing the invader with a nutrient-rich meal, researchers at UT Southwestern Medical Center have found.

18 Aug 2008

Antibodies to 1918 flu pandemic may provide means to tackle bird flu threat

Scientists in the United States have discovered that elderly survivors of the original 1918 flu pandemic, still have immunity to the virus.

18 Aug 2008

Researchers warn of heart risks from energy drinks

Recent research from both Australia and the United States has raised questions about energy drinks and says they may be harmful to some people.

17 Aug 2008

Variation in Ankyrin 3 gene shows strong association with bipolar disorder

The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association between the disorder and variation in two genes that make components of channels that manage the flow of the elements into and out of cells, including neurons.

17 Aug 2008

Spice-based compound to fight against cancer

Seeking to improve on nature, scientists used a spice-based compound as a starting point and developed synthetic molecules that, in lab settings, are able to kill cancer cells and stop the cells from spreading.

17 Aug 2008