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Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The drug denosumab is currently used to treat osteoporosis and bone metastases. For more than a decade, its potential therapeutic benefit in the treatment of breast cancer has also been studied.

7 Mar 2023

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

In a recent study, researchers analyzed the occurrence of bacterial and viral infections in adults hospitalized with coronavirus disease 2019 (COVID-19) to determine the clinical and demographic features, outcomes, and microbial spectrums associated with bacterial coinfections and the prevalence of viral coinfections.

7 Mar 2023

New way to carry drugs across the blood-brain barrier using nanoparticles

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Researchers performed multi-organ single-cell RNA sequencing of collagen-induced arthritis murine model to evaluate immune-mediated inflammatory disease alterations by characterizing the genome, organizing the organome, and prioritizing pathways in the multi-organ data.

3 Mar 2023

Research identifies a possible treatment strategy for rare bone marrow failure syndrome

Bone marrow is the spongy tissue inside bone responsible for making red blood cells, white blood cells and platelets. Bone marrow failure syndromes lead to an increased risk of developing dangerous infections, anemia and an increased risk of blood cancers.

2 Mar 2023

Reprogrammed tumor cells could teach the body's immune system to fight cancer

Some cities fight gangs with ex-members who educate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.

2 Mar 2023

Using vitamin B5 supplementation to boost red blood cell production in people with myelodysplastic syndromes

Scientists from Barts Cancer Institute at Queen Mary University of London and the Francis Crick Institute, have uncovered why patients with a rare type of blood cancer suffer from ineffective red blood cell production, and how vitamin B5 could be combined with existing drugs to improve outcomes.

1 Mar 2023

What is the role of B cells in breast cancer pathology?

In a recent study published in Cancers, researchers comprehensively summarized all available information about B cells in the context of breast cancer.

1 Mar 2023

This dental device was sold to fix patients’ jaws. Lawsuits claim it wrecked their teeth.

Boja Kragulj, an accomplished clarinetist who once performed with orchestras in New York, Philadelphia, and Jacksonville, Florida, has already lost four teeth. And she expects to lose at least a dozen more.

1 Mar 2023

Large cell therapy trial in patients with chronic heart failure shows promising results

Physician-scientists at The Texas Heart Institute announced today the results of the largest cell therapy trial to date in patients with chronic heart failure due to low ejection fraction.

27 Feb 2023

Bacteria-loaded ink used to 3D-print strong, resilient living structural biocomposites

EPFL researchers have published a method for 3D-printing an ink that contains calcium carbonate-producing bacteria.

23 Feb 2023

Skipping meals can trigger a negative effect on immune cells

Fasting may be detrimental to fighting off infection, and could lead to an increased risk of heart disease, according to a new study by the Icahn School of Medicine at Mount Sinai.

23 Feb 2023

Poor air quality may be a risk factor for bone loss from osteoporosis among postmenopausal women

Elevated levels of air pollutants are associated with bone damage among postmenopausal women, according to new research led by scientists at Columbia University Mailman School of Public Health.

21 Feb 2023

Gut dysbiosis and sepsis susceptibility among pregnant women

Researchers describe the role of gut dysbiosis during pregnancy in promoting excessive macrophage pyroptosis, which increases vulnerability to sepsis.

19 Feb 2023

Understanding neural crest cell development will help to better comprehend craniofacial birth defects

Craniofacial birth defects, including cleft lip and palate, are among the most common human congenital malformations.

16 Feb 2023

Machine learning algorithm predicts DNA insertion efficiency of prime editing

A new tool to predict the chances of successfully inserting a gene-edited sequence of DNA into the genome of a cell, using a technique known as prime editing, has been developed by researchers at the Wellcome Sanger Institute.

15 Feb 2023

Perspectives on the Mediterranean diet, gut health, and microbiome in supporting healthy aging

Researchers explored the awareness of the Mediterranean diet and its impacts among older persons and healthcare professionals.

15 Feb 2023

As opioids mixed with animal tranquilizers arrive in Kensington, so do alarming health challenges

Many people living on the streets in Philadelphia's Kensington neighborhood — the largest open-air drug market on the East Coast — are in full-blown addiction, openly snorting, smoking, or injecting illicit drugs, hunched over crates or on stoops. Syringes litter sidewalks, and the stench of urine fouls the air.

15 Feb 2023

$Older wheelchair users have reduced risk of fractures$

Older wheelchair users have reduced risk of fractures

Being a frail elderly person and using a wheelchair involves a substantially reduced risk of fractures, a University of Gothenburg study shows.

14 Feb 2023

How are changes in coffee and caffeine intake associated with changes in fat tissue?

A recent study published in Clinical Nutrition evaluated the associations between changes in coffee and caffeine consumption and fat tissue changes.

14 Feb 2023

Bone News and Research

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

Prevalence and clinical outcomes of viral and bacterial coinfections in hospitalized COVID-19 patients

New way to carry drugs across the blood-brain barrier using nanoparticles

Multi-organ scRNA-seq reveals targeting pro- or anti-inflammatory regulators may be exploited for personalized treatment of immune diseases

Research identifies a possible treatment strategy for rare bone marrow failure syndrome

Reprogrammed tumor cells could teach the body's immune system to fight cancer

Using vitamin B5 supplementation to boost red blood cell production in people with myelodysplastic syndromes

What is the role of B cells in breast cancer pathology?

This dental device was sold to fix patients’ jaws. Lawsuits claim it wrecked their teeth.

Large cell therapy trial in patients with chronic heart failure shows promising results

Bacteria-loaded ink used to 3D-print strong, resilient living structural biocomposites

Skipping meals can trigger a negative effect on immune cells

Poor air quality may be a risk factor for bone loss from osteoporosis among postmenopausal women

Gut dysbiosis and sepsis susceptibility among pregnant women

Understanding neural crest cell development will help to better comprehend craniofacial birth defects

Machine learning algorithm predicts DNA insertion efficiency of prime editing

Perspectives on the Mediterranean diet, gut health, and microbiome in supporting healthy aging

As opioids mixed with animal tranquilizers arrive in Kensington, so do alarming health challenges

Older wheelchair users have reduced risk of fractures

How are changes in coffee and caffeine intake associated with changes in fat tissue?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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