CD4 News and Research

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Discovery that protein CD38 interrupts an interaction between the AIDS virus and its point of entry into cells

Cornell University researchers have discovered the 3-D crystal structure of a protein, human CD38, which may lead to important discoveries about how cells release calcium - a mineral used in almost every cellular process.

19 Sep 2005

Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer

Breast cancer often spreads through the lymph nodes in the arm pits (so-called axillary lymph nodes), and whether these lymph nodes are tumor-free or contain small metastases is an important factor in the decision of how aggressively to treat a patient.

6 Sep 2005

Potential new way to fight HIV

Researchers have confirmed for the first time the benefit of an innate defense system present in the few patients who remain healthy after years of infection with HIV despite receiving no treatment, according to an article published in the September edition of the Journal of Virology.

1 Sep 2005

New strategy to turn off the function of a special group of T cells to suppress immune response to tumors

A special stretch of genetic material may turn off the immune suppression that stymies attempts to fight cancer with a vaccine, said researchers at Baylor College of Medicine (BCM) at Houston.

26 Aug 2005

Body's own defense mechanism causes some of the most serious asthma symptoms

McGill University Health Centre (MUHC) scientists have discovered that our body's own defense mechanism causes some of the most serious asthma symptoms.

13 Aug 2005

Moving towards a cheap and easy way to monitor HIV/AIDS

Doctors regularly monitor the level of an immune cell in the blood called a CD4 cell in HIV-infected individuals, to decide when to start treatment and when to change medications.

19 Jul 2005

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

Patients with rheumatoid arthritis are at increased risk of coronary artery disease

The findings of research published today in Arthritis Research & Therapy show that CAD is accelerated in RA patients, and patients with both RA and CAD are at an increased risk of death from heart disease.

28 Jun 2005

OHSU scientists say low FOXP3 means fewer disease-fighting cells, but new drug may help multiple sclerosis

Oregon Health & Science University researchers have measured genetic changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis.

27 Jun 2005

Inexpensive tests can be used to decide who needs HIV treatment in poor countries

Researchers from the Johns Hopkins Bloomberg School of Public Health, Centers for Disease Control and Prevention and the Chiang Mai University in Thailand, evaluated the ability of inexpensive biological markers, which are obtainable in resource-poor countries, to determine which HIV-infected patients are in the greatest need of antiretroviral therapy.

20 Jun 2005

HIV deaths drop 90 percent among African-American IDUs who are given access to combination drug therapy

Combination drug therapy effectively reduces 90 percent of HIV deaths in African-American injection drug users when they are given ample access to care, according to a new Academy study in the June issue of the American Journal of Epidemiology.

1 Jun 2005

Two-photon imaging gives real-time video of cells in living tissue

Biologists have a new tool to track and videotape cells moving about inside living tissue.

3 May 2005

HIV treatment not affected by hormonal birth control

Estrogen and progesterone hormones in birth control do not influence the effectiveness of highly active antiretroviral therapy (HAART), which is used to treat HIV infection, according to researchers from the Johns Hopkins Bloomberg School of Public Health and other institutions. The study is published in the May 1, 2005, issue of the American Journal of Epidemiology.

2 May 2005

New guidelines for managing chronic kidney disease in patients living with HIV infection

The HIV Medicine Association has released guidelines for managing chronic kidney disease in patients living with HIV infection. They are published in the June 1 issue of Clinical Infectious Diseases.

27 Apr 2005

Scientists have discovered the mechanism that enables some CD4 T cells - the main target of HIV - to thwart the virus

The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD.

13 Apr 2005

HIV treatment-experienced patients set high standards for therapy success

Patients who have previously failed at least two anti-HIV regimens continue to have high standards for their treatment success, according to a survey commissioned by the American Foundation for AIDS Research (amfAR).

11 Apr 2005

Stress might actually be beneficial to health

New research has surprisingly shown that stress, generally thought to be bad for the immune system by lowering the body's ability to fight off disease, on a short-term basis might actually be beneficial.

6 Apr 2005

Novel method to reduce cat allergic reactions

Scientists have discovered a novel method to reduce cat allergic reactions by topping up the immune cells responsible for controlling them.

6 Apr 2005

Surprising discovery about natural immunity to pneumococcus

Since 2000, U.S. infants have been routinely immunized against pneumococcal (Streptococcus pneumoniae) infection. Now, Boston researchers have made a surprising discovery about natural immunity to pneumococcus.

29 Mar 2005

AIDS virus initially more destructive than first thought

The AIDS virus destroys more than half of the immune cells that might recognize and help fight it, within days of infection according to US researchers, and this revelation might necessitate a re-evaluation of how the deadly infection should be tackled.

28 Mar 2005