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Insulin regulates the secretion of the antiaging hormome Klotho

Dr. Carmela Abraham, a professor of biochemistry and medicine at Boston University School of Medicine (BUSM), reports this week in the Proceedings of the National Academy of Sciences new findings on Klotho, an anti-aging gene that is associated with life span extension in rodents and humans.

27 Nov 2007

Chlamydia pneumoniae involved in both heart disease and infertility

Outside the laboratory, Anthony Azenabor is outgoing and talkative, an extrovert who laughs heartily at his own jokes.

21 Nov 2007

Scientists zero in on the cellular machinery that enables neurons to fire

Toy robots with removable body parts - you probably had fun swapping their heads, imagining how it would affect their behavior. Scientists supported by the National Institutes of Health have been performing similar experiments on ion channels - pores in our nerve cells - to sort out the channels' key functional parts.

15 Nov 2007

New target for MS treatment found using old drug

A drug currently used to treat high blood pressure and heart failure has been found to reduce the symptoms of multiple sclerosis in mice.

13 Nov 2007

Discovery of key pathway, potential drug targets in autoinflammatory disease

Molecular biologists at Jefferson's Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases.

13 Nov 2007

How does the antitumor drug get to the cell nucleus?

Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus Italian researchers have now proven that a copper transport protein may play a critical role.

5 Nov 2007

Hairpin peptide mimetics show promise as new drugs to fight HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins.

5 Nov 2007

Researchers discover new gene responsible for Brugada syndrome

Researchers at the University of Pittsburgh School of Medicine have identified a new gene responsible for a rare, inherited form of sudden cardiac arrest, known as Brugada syndrome.

1 Nov 2007

Copper transporter plays an unexpected role in the absorption of cisplatin

30 Oct 2007

Odd protein interaction guides development of olfactory system

Scientists have discovered a strange mechanism for the development of the fruit fly antennal lobe, an intricate structure that converts the chaotic stew of odors in the environment into discrete signals in the brain.

29 Oct 2007

Hairpin-shaped mimetics imitate the helical protein that plays a role in the spread of HIV

29 Oct 2007

Increased intestinal permeability by exogenous sphingomyelinase

Many signaling molecules involved in the pathogenesis of IBD, such as TNF or IFN, infections with bacteria or viruses and ionizing radiation, may cause an alteration of the lipid composition in the cell membrane by activation of sphingomyelinases (SMases).

24 Oct 2007