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Study: Specific class of drugs can be repurposed to treat genetic diseases

Researchers at the University of Illinois Chicago have published a study showing a promising approach to using drug repurposing to treat genetic diseases.

17 Dec 2020

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Researchers demonstrated that neuroinvasion and encephalitis caused by SARS-CoV-2 is associated with significant mortality in a special mouse model.

17 Dec 2020

Researchers use new method to deliver anti-cancer drug to suppress tumor growth

Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability.

17 Dec 2020

Researchers use bacterial strains to measure host gene expression in mouse model

The bacteria Streptococcus pneumoniae colonizes the nasopharynx and can cause pneumonia. Then, it can spread from the lungs to the bloodstream and cause organ damage.

16 Dec 2020

Scientists demonstrate a promising strategy for treating lymphomas

Scientists at Scripps Research have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes.

16 Dec 2020

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

A pair of copper radionuclides that target the somatostatin receptor overexpressed in neuroendocrine tumors has proven successful in identifying tumors and improving survival.

16 Dec 2020

Mild exercise habits during development could prevent schizophrenia, study reveals

Although schizophrenia is increasingly understood as a neurodevelopmental disorder, environmental factors are known to play an important role in the disease onset and progression.

16 Dec 2020

Study provides valuable interaction about animal host and pathogen during pneumococcal infections

Researchers at the University of Maryland School of Medicine published one of the most comprehensive analyses of how genes get expressed during infection (known as a transcriptome). The analyses include three different strains of the bacteria Streptococcus pneumoniae, which causes pneumonia, meningitis, and middle-ear infections.

15 Dec 2020

Microglial surveillance helps prevent seizure activity in the brain

An important part of the brain's immune system, cells called microglia constantly extend and retract "branches" from their cell body to survey their environment.

14 Dec 2020

Study unlocks some muscle cell secrets

A muscle fiber consists of just one cell, but many nuclei. A team at the MDC led by Professor Carmen Birchmeier has now shown just how varied these nuclei are.

11 Dec 2020

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

"Wet" age-related macular degeneration (AMD) is one of the most common causes of irreversible vision loss in the elderly, and it occurs when abnormal and leaky blood vessels form in the retina, in part due to inflammation.

11 Dec 2020

Scientist pinpoints genes that promote the growth of prostate cancer cells

Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.

11 Dec 2020

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Most autism spectrum disorders have a complex, multifactorial genetic component, making it difficult to find specific treatments. Rett syndrome is an exception.

9 Dec 2020

Reductive stress promotes protein aggregation in neuroblastoma cells, impairs neurogenesis

Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at the other end of the spectrum -- reductive stress, or RS -- may affect neurons.

8 Dec 2020

Mice study shows how COVID-19 damages organs other than the lungs

UCLA researchers are the first to create a version of COVID-19 in mice that shows how the disease damages organs other than the lungs.

8 Dec 2020

Research team develops a new decoding method for viral genes

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

7 Dec 2020

Drug prescribed for rare enzyme deficiency shows promise to treat herpes viruses

A drug currently prescribed to treat a rare enzyme deficiency can help cells clear the herpes simplex 1 and herpes simplex 2 viruses, according to a new study published in the journal Science Advances.

7 Dec 2020

Chronic sleep disruption can lead to depression in adolescents, study shows

Chronic sleep disruption during adolescence can lead to depression in both males and females and alters stress reactivity in females, according to a new study led by University of Ottawa researchers.

7 Dec 2020

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

The COVID-19 pandemic is showing a strong comeback after an initial reduction in the number of cases, following energetic public health interventions.

7 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

Mouse Model News and Research

Study: Specific class of drugs can be repurposed to treat genetic diseases

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Researchers use new method to deliver anti-cancer drug to suppress tumor growth

Researchers use bacterial strains to measure host gene expression in mouse model

Scientists demonstrate a promising strategy for treating lymphomas

NET study: New theranostic approach effective in reducing tumor volume and extending lifespan

Mild exercise habits during development could prevent schizophrenia, study reveals

Study provides valuable interaction about animal host and pathogen during pneumococcal infections

Microglial surveillance helps prevent seizure activity in the brain

Study unlocks some muscle cell secrets

Research reveals insights into potential drivers of 'wet' age-related macular degeneration

Scientist pinpoints genes that promote the growth of prostate cancer cells

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Reductive stress promotes protein aggregation in neuroblastoma cells, impairs neurogenesis

Mice study shows how COVID-19 damages organs other than the lungs

Research team develops a new decoding method for viral genes

Drug prescribed for rare enzyme deficiency shows promise to treat herpes viruses

Chronic sleep disruption can lead to depression in adolescents, study shows

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

Findings about primary cilia may be relevant for transplantation therapies in diabetes

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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