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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.

25 Mar 2020

A genetic toolkit to produce multifunctional magnetic nanoparticles

Magnetic bacteria might soon be used for the production of novel biomaterials. A team of microbiologists at the University of Bayreuth led by Prof. Dr. Dirk Schüler developed a modular system for the genetic reprogramming of bacteria, thereby turning the organisms into cell factories for multifunctional magnetic nanoparticles that combine various useful functions and properties.

25 Mar 2020

Diet, nutrition have profound impact on microbial composition in the gut

Nutrition and diet have a profound impact on microbial composition in the gut, in turn affecting a range of metabolic, hormonal, and neurological processes, according to a literature review by scientists from the George Washington University and the National Institute of Standards and Technology.

25 Mar 2020

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.

25 Mar 2020

Mapping the cannabis genome to improve agriculture and human health

Unlocking the full potential of cannabis for agriculture and human health will require a co-ordinated scientific effort to assemble and map the cannabis genome, says a just-published international study led by University of Saskatchewan researchers.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Researchers investigate how cellular protein shredders can be programmed to fight cancer

An international team of researchers led by the Universities of Bonn and Ulm has investigated how a cell's own "protein shredder" can be specifically programmed to fight cancer.

25 Mar 2020

Research shows how stress restructures the brain

Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in JNeurosci.

25 Mar 2020

Novel imaging technique sheds light on Alzheimer's disease

To understand what happens in the brain when Alzheimer's disease develops, researchers need to be able to study the molecular structures in the neurons affected by Alzheimer's disease.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Changes in surface sugarlike molecules help cancer cells to spread

Changes in a specific type of sugarlike molecule, or glycan, on the surface of cancer cells help them to spread into other tissues, according to researchers at the University of California, Davis. Published March 23 in Proceedings of the National Academy of Sciences, the work could lead to diagnostic tests and new therapies to slow or stop the spread of cancers.

25 Mar 2020

Scientists discover tuberculosis bacterium channels vitamins into the cell

A new study published in the journal Nature in March 2020 reports a unique transport protein found within the tubercle bacillus, Mycobacterium tuberculosis. This huge membrane-spanning vesicular protein is different from other transport proteins and is instrumental in carrying hydrophilic molecules, notably vitamin B12 or cobalamin, across the cell membrane.

24 Mar 2020

Quality of diet among young Americans remains poor

Poor diet is a significant contributor to chronic diseases, including cardiovascular disease, cancer, obesity, and diabetes accounting for early mortality. A new study published in the journal JAMA in March 2020 shows that dietary deficiency is both prevalent and pathogenic in today’s young America.

24 Mar 2020

Researchers propose a stopgap measure to help Covid-19 patients in respiratory distress

Researchers at MIT and the University of Colorado at Denver have proposed a stopgap measure that they believe could help Covid-19 patients who are in acute respiratory distress.

24 Mar 2020

Study: Bacterial protein fragment instigates lung tissue death in pulmonary fibrosis

A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan.

24 Mar 2020

Research reveals important mechanism in the repair of DNA double-strand breaks

Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research published today in eLife.

24 Mar 2020

Drebrin autoantibodies trigger epilepsy

Certain forms of epilepsy are accompanied by inflammation of important brain regions. Researchers at the University of Bonn have now identified a mechanism that explains this link.

24 Mar 2020

Researchers identify novel blood-based markers to detect Alzheimer’s disease

In a recent study published in the Journal of Alzheimer’s Disease, researchers at Okayama University developed a technique to uncover molecules within the blood which can help doctors differentiate patients with Alzheimer’s disease from healthy individuals.

24 Mar 2020

Old human cells regain youthful strength after rejuvenating protein treatment, study finds

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

24 Mar 2020

Fast & effective removal of interfering proteins

Incorporating a novel dual hydrophobically treated matrix filter, Microlute™ Protein Precipitation Plate from Porvair Sciences set a new standard for labs looking to remove interfering proteins from serum, plasma or even whole blood samples prior to analysis by Liquid Chromatography / Mass Spectrometry (LC/MS).

From Porvair Sciences Limited 24 Mar 2020