Fast & effective removal of interfering proteins

Incorporating a novel dual hydrophobically treated matrix filter, Microlute™ Protein Precipitation Plate from Porvair Sciences set a new standard for labs looking to remove interfering proteins from serum, plasma or even whole blood samples prior to analysis by Liquid Chromatography / Mass Spectrometry (LC/MS).

Fast & effective removal of interfering proteins
A Microlute™ Protein Precipitation Plate (PPP)

Biological samples commonly contain proteins that interfere with downstream applications such as LC/MS analysis. Microlute™ Protein Precipitation Plates (PPP) use the CRASH method, in which protein is denatured with acetonitrile and the flocculant filtered out, allowing 96 samples to be processed in parallel.

Based on the industry standard MicroLute™ format, but without the chromatographic sorbent, protein ‘crashes’ out of solution and precipitates directly in each well when acetonitrile is added, thus solving all common problems associated with the CRASH technique of protein clean-up. The novel dual frit, hydrophobically treated matrix used by the Microlute™ PPP means that there is no ‘wetting out’ and leakage of sample before the application of vacuum.

Due to its ease of use, high performance and reliability the Microlute™ PPP is commonly used as the protein precipitation plate of choice in many major pharmaceutical companies worldwide.

To review the operational protocol for the Microlute™ PPP please visit  To watch a video demonstration of the Microlute™ PPP please visit


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Porvair Sciences Limited. (2020, March 24). Fast & effective removal of interfering proteins. News-Medical. Retrieved on June 22, 2024 from

  • MLA

    Porvair Sciences Limited. "Fast & effective removal of interfering proteins". News-Medical. 22 June 2024. <>.

  • Chicago

    Porvair Sciences Limited. "Fast & effective removal of interfering proteins". News-Medical. (accessed June 22, 2024).

  • Harvard

    Porvair Sciences Limited. 2020. Fast & effective removal of interfering proteins. News-Medical, viewed 22 June 2024,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Porous PTFE components for demanding applications