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Brain changes related to Alzheimer’s occur years before the onset of clinical symptoms

In a records review of 290 people at risk for Alzheimer's disease, scientists at Johns Hopkins say they have identified an average level of biological and anatomical brain changes linked to Alzheimer's disease that occur three to 10 years -- some even more than 30 years -- before the disease's first recognizable symptoms appear.

From Johns Hopkins Medicine 15 May 2019

Fruit fly study shows role of unexplored neural circuit in modulating memory strength

Learning to avoid negative experiences requires an interplay of two distinct brain circuits, one to interpret "Yikes!" and drive learning, and the other, unexpectedly, to dial in the strength of that memory, a new fruit fly study shows.

15 May 2019

Glucosamine supplements could benefit the heart

Glucosamine supplements are used by hundreds of thousands of patients worldwide to relieve the joint pain caused due to osteoarthritis.

14 May 2019

Researchers elucidate the mechanism underlying dead-zone generation in circadian clocks

Most organisms on Earth have circadian clocks. In mammals, the circadian pacemaker is located in the suprachiasmatic nucleus of the brain.

14 May 2019

Researchers discover biochemical agent responsible for blood pressure drop in sepsis

A study conducted by an international group of researchers has overturned the understanding of life-threatening inflammatory diseases such as sepsis, pointing to a biochemical agent that may be involved in the rapid decline in blood pressure that occurs in the advanced stage of sepsis and usually causes the patient's death. This discovery could pave the way for novel therapeutic approaches.

14 May 2019

Bladder drug can accelerate atheroclerosis in mice

A drug used in the treatment of overactive bladder can accelerate atheroclerosis in mice, researchers at Karolinska Institutet in Sweden report in a study published in the Proceedings of the National Academy of Sciences.

14 May 2019

Researchers identify new molecular mechanism causing rheumatoid arthritis

A collaborative study by research groups from the University of Cologne, VIB, Ghent University, the Βiomedical Sciences Research Center 'Alexander Fleming' in Athens and the University of Tokyo identified a new molecular mechanism causing rheumatoid arthritis.

14 May 2019

Rare gene mutation may prevent heart disease, study reveals

Targeting apolipoprotein B gene has not been tested in clinical trials for cardiovascular outcomes because of risk of fatty liver disease, but naturally-occurring mutation suggests it may be effective.

13 May 2019

Harvard scientists uncover key mechanism that allows viruses to replicate

Viruses are masterful invaders. They cannibalize host cells by injecting their genetic material, often making thousands of copies of themselves in a single cell to ensure their replication and survival.

13 May 2019

Brazilian researchers develop new strategy to starve triple negative breast cancer cells

A team of Brazilian researchers has developed a strategy that slows the growth of triple negative breast cancer cells by cutting them off from two major food sources.

13 May 2019

Jefferson researcher discovers a population of bone cells that subdues cancer

In breast cancer, there are cases of women and men whose cancer returns in their bones 20-30 years after they were treated for their primary disease and thought they were cancer-free.

13 May 2019

Research on repetitive worm behavior may shed light on repetition in humans

Repetition can be useful if you're trying to memorize a poem, master a guitar riff, or just cultivate good habits.

13 May 2019

Scientists investigate function of AAPP in mosquito blood feeding

Biting insects use a range of tools when sucking blood from hosts to maximize their chances of a good meal.

13 May 2019

Researchers reveal ebb and flow of gene expression that may awaken neural stem cells

The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells -- neurons -- have limited ability to regenerate.

13 May 2019

International team studies potential cancer suppression mechanisms in cetaceans

Scientists know that age and weight are risk factors in the development of cancer. That should mean that whales, which include some of the largest and longest-lived animals on Earth, have an outsized risk of developing cancer.

13 May 2019

New findings could facilitate the development of hepatitis C mouse model

Small differences in a liver cell protein have significant impacts on hepatitis C virus replication in mice and humans, findings that could facilitate the development of a mouse model of the infection. The report, led by researchers at Princeton University, was published today in the journal eLife.

12 May 2019