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Study finds high degree of discordance between Myriad Genetics and public database in BRCA1 and BRCA2 variant classifications

Myriad Genetics, Inc., a leader in molecular diagnostics and personalized medicine, today announced that new data comparing BRCA1 and BRCA2 variant classifications between Myriad Genetics and a commonly used public genetic database was published in the journal The Oncologist.

21 Apr 2017

Environmental 'memory' can be passed on in genes for many generations

Led by Dr Ben Lehner, group leader at the EMBL-CRG Systems Biology Unit and ICREA and AXA Professor, together with Dr Tanya Vavouri from the Josep Carreras Leukaemia Research Institute and the Institute for Health Science Research Germans Trias i Pujol, the researchers noticed that the impact of environmental change can be passed on in the genes for many generations while studying C. elegans worms carrying a transgene array - a long string of repeated copies of a gene for a fluorescent protein that had been added into the worm genome using genetic engineering techniques.

20 Apr 2017

Study reveals potential therapeutic target for kidney fibrosis

When the kidneys - vital organs for filtering the body's entire blood supply - become injured, it can set in motion an unfortunate chain of events that leads to a decline in health.

20 Apr 2017

Rat study reveals new clues to devastating neurological disease

After a 29-year quest, Ian Duncan, a professor of veterinary medicine at the University of Wisconsin-Madison, has finally pinpointed the cause of a serious neurologic disease in a colony of rats.

20 Apr 2017

Scientists find new way to measure tau protein levels in the blood

Damaging tangles of the protein tau dot the brains of people with Alzheimer's and many other neurodegenerative diseases, including chronic traumatic encephalopathy, which plagues professional boxers and football players.

20 Apr 2017

Medical complications of brown recluse spider bites can be severe in children

Medical complications of brown recluse spider bites are uncommon but they can be severe, particularly in children, researchers at Vanderbilt University Medical Center reported today.

19 Apr 2017

Penn researchers pinpoint underlying cause of Best disease

Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients age.

19 Apr 2017

TSRI scientists reveal important role of genetics in brain circuits

Scientists at The Scripps Research Institute in La Jolla have revealed new clues to the wiring of the brain. A team led by Associate Professor Anton Maximov found that neurons in brain regions that store memory can form networks in the absence of synaptic activity.

19 Apr 2017

Brain cancer patient treated with malaria drug shows dramatic improvement

After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl's doctors gave her only a few months to live.

19 Apr 2017

Researchers report new evidence that defective HIV proviruses distract immune system

Researchers at Johns Hopkins and George Washington universities report new evidence that proteins created by defective forms of HIV long previously believed to be harmless actually interact with our immune systems and are actively monitored by a specific type of immune cell, called cytotoxic T cells.

19 Apr 2017

CIRM funds clinical study to test safety, efficacy of new retinitis pigmentosa treatment

Cell therapy company jCyte is launching a phase 2b clinical trial to test the safety and efficacy of its developmental retinitis pigmentosa (RP) treatment, jCell.

19 Apr 2017

Researchers use CRISPR technology to create new strain of red-eyed mutant wasps

Researchers at UC Riverside's Akbari lab have brought a new strain of red-eyed mutant wasps into the world.

19 Apr 2017

New blood test can accurately, quickly identify genetic mutations linked to NSCLC

Identification of a specific genetic mutation in patients with non-small-cell lung cancer (NSCLC) helps clinicians select the best treatment option. Potential NSCLC patients usually undergo invasive tissue biopsy, which may often be unnecessary and delays treatment.

19 Apr 2017

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

Antidepressant use during early pregnancy not linked to risk of autism, ADHD in kids, study shows

A study led by Indiana University suggests that mothers' use of antidepressants during early pregnancy does not increase the risk of their children developing autism or attention deficit hyperactivity disorder, conditions previously associated with these medications.

18 Apr 2017

Research reveals how liver progenitor cells contribute to development of hepatic tumors

The malignant transformation of hepatocytes is the origin of most hepatocellular carcinomas, an aggressive type of liver cancer with high mortality rates. But these cells do not act alone.

18 Apr 2017

New 7-gene test strategy could improve life expectancy for women at risk of hereditary breast cancer

Value in Health, the official journal of the International Society for Pharmacoeconomics and Outcomes Research, announced today the publication of new research indicating that testing for variants in 7 cancer-associated genes (versus the usual process of testing in just 2 genes) followed by risk-reduction management could cost-effectively improve life expectancy for women at risk of hereditary breast cancer.

17 Apr 2017

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ("good" fat) by employing two receptors on BAT cells as potential therapeutic targets.

17 Apr 2017

New online genetic study aims to enroll 50,000 individuals and families affected by autism

Autism has a strong genetic component. To date, approximately 50 genes have been identified that almost certainly play a role in autism, and researchers estimate that at least an additional 300 are involved.

17 Apr 2017

Microscopic probes simplify process of measuring electrical signals in small animals

Microscopic probes developed at Rice University have simplified the process of measuring electrical activity in individual cells of small living animals. The technique allows a single animal like a worm to be tested again and again and could revolutionize data-gathering for disease characterization and drug interactions.

17 Apr 2017

Genetic News and Research

Study finds high degree of discordance between Myriad Genetics and public database in BRCA1 and BRCA2 variant classifications

Environmental 'memory' can be passed on in genes for many generations

Study reveals potential therapeutic target for kidney fibrosis

Rat study reveals new clues to devastating neurological disease

Scientists find new way to measure tau protein levels in the blood

Medical complications of brown recluse spider bites can be severe in children

Penn researchers pinpoint underlying cause of Best disease

TSRI scientists reveal important role of genetics in brain circuits

Brain cancer patient treated with malaria drug shows dramatic improvement

Researchers report new evidence that defective HIV proviruses distract immune system

CIRM funds clinical study to test safety, efficacy of new retinitis pigmentosa treatment

Researchers use CRISPR technology to create new strain of red-eyed mutant wasps

New blood test can accurately, quickly identify genetic mutations linked to NSCLC

Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

Antidepressant use during early pregnancy not linked to risk of autism, ADHD in kids, study shows

Research reveals how liver progenitor cells contribute to development of hepatic tumors

New 7-gene test strategy could improve life expectancy for women at risk of hereditary breast cancer

Study establishes potential of BAT receptors as druggable targets for treatment of obesity, diabetes

New online genetic study aims to enroll 50,000 individuals and families affected by autism

Microscopic probes simplify process of measuring electrical signals in small animals

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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