Clinical Trial News and Research

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SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

The SWOG S1011 randomized phase 3 trial found no significant improvement in disease-free or overall survival but a higher rate of grade 3-4 adverse events and an increased risk of death in the 90 days after surgery.

3 Oct 2024

Mediterranean diet significantly lowers heart failure risk, especially in women

Increased adherence to the Mediterranean diet significantly lowers the risk of heart failure, especially in women, according to a recent European meta-analysis. The diet's anti-inflammatory and antioxidant properties are key to its protective effects.

3 Oct 2024

New treatment proposed for brain metastases resistant to immunotherapy

Researchers at the Spanish National Cancer Research Centre (CNIO) propose a new treatment for brain metastases that respond poorly, or not at all, to immunotherapy, and provide a biomarker to predict in which cases it should be used.

2 Oct 2024

Dronabinol shows promise in reducing agitation in Alzheimer's patients

In a study led by the Johns Hopkins University School of Medicine and Tufts University School of Medicine, researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana's main ingredient, THC, reduces agitation in patients with Alzheimer's by an average of 30%.

2 Oct 2024

Postmenopausal hormone therapy use declines amidst risk-benefit concerns

A study reveals a sharp decline in menopausal hormone therapy use among U.S. women, highlighting disparities across racial and ethnic groups over two decades.

2 Oct 2024

Atherosclerosis progression associated with increased risk of death in asymptomatic individuals

The progression of atherosclerosis in people who have no symptoms of it is independently associated with the risk of dying from any cause, according to a new study led by researchers from Mount Sinai Fuster Heart Hospital, published September 30 in the Journal of the American College of Cardiology.

1 Oct 2024

Time-restricted eating could offer health benefits to adults with metabolic syndrome

More than one-third of adults in the United States have metabolic syndrome, a cluster of conditions that significantly raise a person's risk of heart disease, stroke, and type 2 diabetes.

1 Oct 2024

Immune modulation as a new strategy to combat periodontal disease

Targeting the immune system could prevent or treat periodontal disease (PD), a common but serious disease of the gums, according to new research from the University of Pittsburgh.

30 Sep 2024

Spirituality and distrust influence Black patients' participation in cancer trials

Spiritual beliefs and a historically-based distrust of clinical research may factor into Black patients' decisions about whether to participate in cancer trials, according to surveys of patients treated at two Baltimore medical centers.

30 Sep 2024

Atherosclerosis burden and progression predict all-cause mortality

A study carried out at Mount Sinaí Fuster Heart Hospital in New York in collaboration with the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid provides important new information about atherosclerosis, a disease in which lipids (cholesterol) and other substances accumulate in plaques on the arterial wall, causing the vessels to harden and narrow, and increasing the risk of severe cardiovascular conditions.

30 Sep 2024

Study shows equal effectiveness of proton beam therapy and IMRT for prostate cancer

People with low- and intermediate-risk prostate cancer treated with either of two types of contemporary radiation therapy - proton beam therapy or intensity modulated radiation therapy (IMRT) - achieved equally high rates of tumor control with no differences in patient-reported quality of life, according to a first-of-its-kind phase III clinical trial comparing the two technologies. Findings of the PARTIQoL trial will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.

30 Sep 2024

New noninvasive device promises early stroke risk detection

A team of researchers from the Keck School of Medicine of USC and California Institute of Technology (Caltech) have developed a potential new way to measure a person's stroke risk that is cost-effective and noninvasive, akin to a cardiac stress test.

30 Sep 2024

Extending survival in meningioma patients with innovative radiopharmaceutical therapy

A radiopharmaceutical therapy that has successfully extended progression-free survival for patients with neuroendocrine tumors shows early promise for delivering similar benefits to patients with difficult-to-treat meningioma, a type of brain tumor.

29 Sep 2024

Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers

Study demonstrates that glutathione (GSH) significantly reduces acetaldehyde levels, a key factor in hangovers, though subjective symptoms showed little difference between groups. Pharmacokinetic data indicate that GSH accelerates acetaldehyde clearance, providing potential relief from hangover symptoms.

29 Sep 2024

UCLA Health researchers showcase advances in radiation oncology at ASTRO

UCLA Health Jonsson Comprehensive Cancer Center researchers and physicians who specialize in treating patients with radiation therapies will present data on the latest radiation oncology research and clinical trial results at the 66th annual American Society for Radiation Oncology (ASTRO) meeting in Washington D.C., Sept. 29 to Oct. 2.

27 Sep 2024

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

27 Sep 2024

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Stroke related to large vessel occlusion (LVO) is a leading cause of disability and death worldwide. Endovascular therapy (minimally invasive procedures like catheterization done inside the blood vessels) has transformed the management of these patients.

26 Sep 2024

Innovative CAR-T cells effectively target glioblastoma with reduced toxicity

Glioblastoma is the most common and most aggressive primary brain tumor, with an average survival after diagnosis of less than two years, and against which current treatments remain ineffective.

26 Sep 2024

High rate of iron deficiency among pregnant women in Ireland revealed

Four out of five pregnant women in Ireland are iron deficient by their third trimester, a University College Cork (UCC) study reveals.

26 Sep 2024

Targeted drug therapy shows promise for ulcerative colitis remission

An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission.

26 Sep 2024

Clinical Trial News and Research

SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

Mediterranean diet significantly lowers heart failure risk, especially in women

New treatment proposed for brain metastases resistant to immunotherapy

Dronabinol shows promise in reducing agitation in Alzheimer's patients

Postmenopausal hormone therapy use declines amidst risk-benefit concerns

Atherosclerosis progression associated with increased risk of death in asymptomatic individuals

Time-restricted eating could offer health benefits to adults with metabolic syndrome

Immune modulation as a new strategy to combat periodontal disease

Spirituality and distrust influence Black patients' participation in cancer trials

Atherosclerosis burden and progression predict all-cause mortality

Study shows equal effectiveness of proton beam therapy and IMRT for prostate cancer

New noninvasive device promises early stroke risk detection

Extending survival in meningioma patients with innovative radiopharmaceutical therapy

Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers

UCLA Health researchers showcase advances in radiation oncology at ASTRO

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Innovative CAR-T cells effectively target glioblastoma with reduced toxicity

High rate of iron deficiency among pregnant women in Ireland revealed

Targeted drug therapy shows promise for ulcerative colitis remission

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