Malignant News and Research

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Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

Pulmospheres, three dimensional multicellular spheroids composed of lung cells from individual patients, were shown to be effective in predicting the efficacy of medications for idiopathic pulmonary fibrosis, according to findings from University of Alabama at Birmingham scientists presented today in JCI Insight, a journal of the American Society for Clinical Investigation.

27 Jan 2017

New study explores how protein production goes off script when skin cells turn cancerous

Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function.

27 Jan 2017

Deaths from diabetes in the U.S. higher than estimated, study shows

The proportion of deaths attributable to diabetes in the U.S. is as high as 12 percent - three times higher than estimates based on death certificates suggest, according to a new analysis led by a Boston University School of Public Health researcher.

27 Jan 2017

AI algorithm as good as dermatologists at spotting skin cancer

Researchers have developed an algorithm that matches or exceeds the ability of dermatologists to diagnose skin cancer, according to a new study. The study authors hope the technology can be integrated into Smartphones, to improve access to medical care.

26 Jan 2017

New project aims to improve efficiency of cytostatic drugs used in cancer treatment

Wilfried Weber, Professor of Synthetic Biology at the University of Freiburg, has received a grant of roughly €150,000 for his project "Hide and Seek with Cancer Drugs" in which he is working to improve the drugs used in cancer treatment

25 Jan 2017

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers.

24 Jan 2017

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

Malignant melanoma is the fastest-growing type of cancer and the most fatal skin disease.

23 Jan 2017

Protein involved in pancreatic cancer development plays more complicated role, study finds

A protein thought to fuel pancreatic cancer development plays a much more complicated role, a new study finds.

18 Jan 2017

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

An enzyme identified in Saccharomyces cerevisiae, commonly known as brewer's or baker's yeast, has passed in vitro trials, demonstrating its capacity to kill acute lymphoblastic leukemia (ALL) cells.

18 Jan 2017

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Standard chemotherapy is a blunt force instrument against cancer - and it's a rare cancer patient who escapes debilitating side effects from systemic treatments that mostly affect dividing cells, both malignant and healthy, throughout the body.

17 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

16 Jan 2017

MUSC scientists design novel antibody-based therapy to fight against cancer

Scientists at the Medical University of South Carolina (MUSC) have designed an antibody-based therapy that could target the functions of TGF-beta that cause cancer

12 Jan 2017

UCM scientists design biosensor capable of detecting cancer autoantibodies at early stages

Before a malignant tumor is developed, the immune system tries to fight against proteins that are altered during their formation, producing certain cancer antibodies.

11 Jan 2017

NCCN publishes new easy-to-understand patient education resources focused on brain cancer

The National Comprehensive Cancer Network has published the NCCN Guidelines for Patients and NCCN Quick Guide sheets for Brain Cancer - Gliomas—the first in a series of patient education resources focused on Brain Cancer.

10 Jan 2017

Scientists develop 3-D organoid to unravel immune response during infection

What if you could design an adaptable, biomaterials-based model of an organ to track its immune response to any number of maladies, including cancer, transplant rejection and the Zika virus? The lab of Ankur Singh, assistant professor in the Sibley School of Mechanical and Aerospace Engineering, has asked - and begun to answer - that very question.

6 Jan 2017

Uterine microbiome study provides important insights into etiology of endometrial cancer

Endometrial cancer triggers remain elusive, despite continued research. But given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease.

6 Jan 2017

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may be due to the elimination of certain genetic mutations needed to enable the immune system to recognize and attack malignant cells.

6 Jan 2017

New research suggests novel combination approach to fight against gliomas

"Devastating" and "dismal." That's how leading researchers describe the present outlook for malignant brain tumors. The median survival rate for patients with glioblastoma multiforme, or GBM, is a mere 14.2 months.

4 Jan 2017

MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study.

3 Jan 2017

Malignant News and Research

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

New study explores how protein production goes off script when skin cells turn cancerous

Deaths from diabetes in the U.S. higher than estimated, study shows

AI algorithm as good as dermatologists at spotting skin cancer

New project aims to improve efficiency of cytostatic drugs used in cancer treatment

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Researchers investigate influence of surrounding tissue on formation and growth of tumor cells

Protein involved in pancreatic cancer development plays more complicated role, study finds

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

Chemotherapy-induced senescent cells promote side effects and cancer relapse

Epigenetic changes drive successful metastases of pancreatic cancer cells

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

MUSC scientists design novel antibody-based therapy to fight against cancer

UCM scientists design biosensor capable of detecting cancer autoantibodies at early stages

NCCN publishes new easy-to-understand patient education resources focused on brain cancer

Scientists develop 3-D organoid to unravel immune response during infection

Uterine microbiome study provides important insights into etiology of endometrial cancer

Cancers acquire resistance to immunotherapy by eliminating tumor-specific genetic mutations

New research suggests novel combination approach to fight against gliomas

MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

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