Clinical Trial News and Research

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Proactively screening diabetes patients for heart disease does not improve long-term survival

While coronary heart disease and diabetes are often seen in the same patients, a diagnosis of diabetes does not necessarily mean that patients also have coronary heart disease, according to a new study from researchers at Intermountain Health in Salt Lake City.

18 Nov 2024

New risk score identifies heart disease risk in kidney transplant patients

Using an innovative risk score assessment score, heart researchers at Intermountain Health in Salt Lake City say they can accurately predict whether patients being assessed for kidney transplant will likely have a future major cardiac event, like a heart attack or stroke, according to a new study.

18 Nov 2024

Blood pressure control improved with dual medication pills in India

Medication variations that combined two of three different blood pressure-lowering medications into a single pill worked equally well in reducing blood pressure and were safe among adults in India, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

18 Nov 2024

Hypertension drug may reduce heart failure risk in people recovering from heart attack

New research found that the medication spironolactone, often prescribed for hypertension (high blood pressure), may reduce the risk of heart failure in people recovering from a heart attack.

18 Nov 2024

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

A large-scale clinical trial found that intravenous infusion of exenatide, a glucagon-like peptide-1 (GLP-1) analog medication, during heart surgeries involving bypass did not significantly reduce the risk of death, stroke or organ failure.

18 Nov 2024

SGLT2 inhibitor canagliflozin shown to improve kidney oxygenation in diabetes patients

Type 2 diabetes can lead to diabetic kidney disease, but a class of drugs that cause the kidneys to remove glucose through urine has been gaining attention.

18 Nov 2024

New clinical trial offers hope for patients with rare immune disease IgG4-RD

A team led by Mass General Brigham researchers demonstrated that inebilizumab reduced the risk of symptoms by 87% in patients with the rare affliction known as immunoglobulin G4–related disease (IgG4-RD)

18 Nov 2024

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Blue light exposure may accelerate bone growth and early puberty in rats

Exposure to blue light, like that from smartphones or tablets, may accelerate bone growth and bone age, leading to early puberty in rats.

15 Nov 2024

Duke-NUS team develops test to monitor engineered T cells in cancer treatment

A novel test developed by Duke-NUS researchers enables real-time monitoring of T cells that have been engineered to fight cancer, after re-introduction into the body of a cancer patient.

15 Nov 2024

International team releases recommendations for AI use in neuro-oncology

An international, multidisciplinary team of leading neuro-oncology researchers and clinicians has released new recommendations for good clinical practice - a set of guidelines that helps ensure clinical trial results are reliable, and patients are protected - regarding the use of artificial intelligence methods to more accurately diagnose, monitor and treat brain cancer patients.

15 Nov 2024

Cognitive behavioral therapy shows promise for prolonged grief disorder

Integrative cognitive behavioral therapy shows greater efficacy than present-centered therapy in reducing grief severity and comorbid symptoms after treatment.

15 Nov 2024

New drug strategy reverses resistance to immunotherapy in pancreatic cancer

A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.

14 Nov 2024

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

An international, phase 3 clinical trial led by investigators at Mass General Brigham could improve the treatment of a rare disease that can cause debilitating symptoms.

14 Nov 2024

Teledermoscopy offers reliable skin cancer diagnosis

Collecting images of suspicious-looking skin growths and sending them off-site for specialists to analyze is as accurate in identifying skin cancers as having a dermatologist examine them in person, a new study shows.

14 Nov 2024

Zambia study finds limited impact of financial support on teenage pregnancies

Many young girls in low- and middle-income countries become pregnant early, which can be dangerous for them and for their babies.

14 Nov 2024

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors.

14 Nov 2024

FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients

A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L), led to a faster recovery of COVID-19 patients and reduced mortality.

14 Nov 2024

Self-reported symptom screening reduces symptom burden in pediatric cancer patients

Regular, self-reported symptom screening was associated with reduced symptom burden when compared with usual care for pediatric patients with cancer, according to new research led by scientists at the University of Toronto and The Hospital for Sick Children (SickKids).

14 Nov 2024

MRI-guided SBRT reduces side effects in prostate cancer treatment

After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

14 Nov 2024

Clinical Trial News and Research

Proactively screening diabetes patients for heart disease does not improve long-term survival

New risk score identifies heart disease risk in kidney transplant patients

Blood pressure control improved with dual medication pills in India

Hypertension drug may reduce heart failure risk in people recovering from heart attack

Intravenous infusion of exenatide fails to reduce risks of complications in heart surgery patients

SGLT2 inhibitor canagliflozin shown to improve kidney oxygenation in diabetes patients

New clinical trial offers hope for patients with rare immune disease IgG4-RD

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

Blue light exposure may accelerate bone growth and early puberty in rats

Duke-NUS team develops test to monitor engineered T cells in cancer treatment

International team releases recommendations for AI use in neuro-oncology

Cognitive behavioral therapy shows promise for prolonged grief disorder

New drug strategy reverses resistance to immunotherapy in pancreatic cancer

Phase 3 study finds inebilizumab effective for immunoglobulin G4–related disease

Teledermoscopy offers reliable skin cancer diagnosis

Zambia study finds limited impact of financial support on teenage pregnancies

New vaccine shows potential in preventing recurrence of triple-negative breast cancer

FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients

Self-reported symptom screening reduces symptom burden in pediatric cancer patients

MRI-guided SBRT reduces side effects in prostate cancer treatment

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