Clinical Trial News and Research

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Targeted therapy improves pregnancy outcomes

Amongst women who experience recurrent pregnancy loss, around 20% test positive for a specific antibody that targets the mother's own body. A Kobe University-led research team now found a treatment that drastically increases these women's chances of carrying to full-term without complications.

26 Sep 2024

Study reveals life-changing impact of gene therapy for hemophilia B patients

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the results of an international Phase III clinical trial published today in the New England Journal of Medicine by researchers from the University of Pennsylvania Perelman School of Medicine and a multicenter group of investigators.

25 Sep 2024

Remote video consultations show positive impact on depression and anxiety

Remote video consultations between patients and mental health specialists show a small but significant improvement on symptoms of depression and anxiety, finds a trial published by The BMJ today.

25 Sep 2024

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

The safety and effectiveness of donanemab - an Alzheimer's drug recently approved by the US Food & Drug Administration (FDA) - is called into question in an investigation published by The BMJ today.

25 Sep 2024

Study links semaglutide to reduced opioid overdose risk in patients with OUD and diabetes

Since being deemed a public health emergency in 2017, opioids are responsible for 72% of drug overdose deaths in the United States, according to the National Center for Drug Abuse Statistics.

25 Sep 2024

University of Pittsburgh receives $100 million to enhance trauma care research

The University of Pittsburgh Schools of the Health Sciences has been awarded approximately $100 million from the U.S. Department of Defense (DOD) to continue a clinical research program that is advancing trauma care.

25 Sep 2024

Steritas' Pediatric Glucocorticoid Toxicity Index applied in clinical trial to assess steroid-toxicity

Steritas LLC., a company dedicated to enhancing patient care for steroid-treated patients announced that Alder Hey Children’s NHS Foundation Trust, and the Liverpool Clinical Trials Centre will apply its Steritas Pediatric Glucocorticoid Toxicity Index (pGTI) in a clinical trial to compare efficacy, safety and cost-effectiveness of intravenous versus oral glucocorticoids (steroids) for children and young people with Juvenile Idiopathic Arthritis (JIA).

From Steritas LLC 25 Sep 2024

New approach to B-ALL treatment reduces side effects and enhances survival

Clinical trial results from St. Jude Children's Research Hospital demonstrate benefits to using genomics and early treatment response to guide risk classification of children with B-cell acute lymphoblastic leukemia (B-ALL).

24 Sep 2024

Innovative ALS study receives $22 million grant for experimental drug

Mayo Clinic in Florida has received a grant from the National Institute of Neurological Disorders and Stroke (NIDS) to begin an innovative study that will provide hundreds of patients with amyotrophic lateral sclerosis (ALS) access to the experimental drug ibudilast over six months.

24 Sep 2024

Neurostimulation target identified for treating PTSD in veterans

A new study led by researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder (PTSD) in veterans.

24 Sep 2024

New drug combo shows promise for deeper remission in chronic leukemia

Researchers leading the SWOG S1712 clinical trial have found that adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) treatment for patients with chronic-phase chronic myeloid leukemia (CP-CML) significantly increased the percentage of patients who had a molecular response deep enough to warrant discontinuing treatment.

24 Sep 2024

Medicare coverage for obesity drug raises questions

Millions of older Americans with obesity could potentially get Medicare's help with the hefty price of a weight-loss medication in order to reduce their high risk of heart problems.

23 Sep 2024

New model identifies cancer patients at high risk for ER visits during clinical trials

Investigators from the SWOG Cancer Research Network have developed and validated a risk prediction model for identifying which patients with advanced cancer who are enrolled to clinical trials are at highest risk for unplanned emergency room (ER) visits and hospital stays.

23 Sep 2024

New defibrillation strategy could enhance survival rates in cardiac arrest

Joshua Lupton, M.D., has no memory of his own cardiac arrest in 2016. He only knows that first responders resuscitated his heart with a shock from a defibrillator, ultimately leading to his complete recovery and putting him among fewer than one in 10 people nationwide who survive cardiac arrest outside of a hospital.

23 Sep 2024

Urgent call for long-term investment in antibiotic research

Antibiotic resistance is a global public health threat. Modern health systems rely on antibiotics to prevent and treat infections, and the need for new drugs is urgent.

23 Sep 2024

Chemotherapy linked to increased cardiovascular risks in older cancer survivors

A study based on clinical trial data found higher risks of stroke, heart attack, and hospital admission for heart failure in older cancer survivors.

23 Sep 2024

Psilocybin shows promise for treating depression and improving well-being

A direct comparison between the experimental psychedelic drug psilocybin and a standard SSRI antidepressant shows similar improvement of depressive symptoms, but that psilocybin offers additional longer-term benefits.

22 Sep 2024

Sexual health symptoms associated with lower adherence to breast cancer therapy in Black women

Among patients with early-stage breast cancer treated with adjuvant endocrine therapy (AET), symptoms related to sexual health were associated with decreased adherence to treatment in Black women, according to results presented at the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held September 21-24, 2024.

21 Sep 2024

Stroke risk rises in patients with sickle cell disease despite established guidelines

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a study published today in Blood.

20 Sep 2024

UCLA develops largest collection of patient-derived organoids for sarcoma research

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient.

20 Sep 2024

Clinical Trial News and Research

Targeted therapy improves pregnancy outcomes

Study reveals life-changing impact of gene therapy for hemophilia B patients

Remote video consultations show positive impact on depression and anxiety

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

Study links semaglutide to reduced opioid overdose risk in patients with OUD and diabetes

University of Pittsburgh receives $100 million to enhance trauma care research

Steritas' Pediatric Glucocorticoid Toxicity Index applied in clinical trial to assess steroid-toxicity

New approach to B-ALL treatment reduces side effects and enhances survival

Innovative ALS study receives $22 million grant for experimental drug

Neurostimulation target identified for treating PTSD in veterans

New drug combo shows promise for deeper remission in chronic leukemia

Medicare coverage for obesity drug raises questions

New model identifies cancer patients at high risk for ER visits during clinical trials

New defibrillation strategy could enhance survival rates in cardiac arrest

Urgent call for long-term investment in antibiotic research

Chemotherapy linked to increased cardiovascular risks in older cancer survivors

Psilocybin shows promise for treating depression and improving well-being

Sexual health symptoms associated with lower adherence to breast cancer therapy in Black women

Stroke risk rises in patients with sickle cell disease despite established guidelines

UCLA develops largest collection of patient-derived organoids for sarcoma research

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