Kinase News and Research

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Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

A team including the National Cancer Center, the RIKEN Center for Life Science Technologies , and Carna Biosciences Inc., has jointly announced the development of a novel small-molecule Wnt inhibitor named NCB-0846.

26 Aug 2016

Researchers reveal first three-dimensional molecular map of protein linked to many cancers

Walter and Eliza Hall Institute researchers have revealed for the first time the three-dimensional molecular 'map' of a protein that has been pinpointed as a driver of many types of cancers.

19 Aug 2016

Study shows leptomeningeal metastases more prevalent in NSCLC patients with EGFR mutations

Leptomeningeal metastases (LM), a devastating complication and predictor of poor survival in lung cancer patients, was found to be more prevalent in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.

16 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Cold plasma could help bones heal faster, study shows

Cold plasma looks like the glow from the "Star Wars" blue light saber but this beam of energy, made of electrons that change polarity at micro-second or nanosecond speeds, could help bones heal faster, according to a study published August 11th in the Journal of Tissue Engineering and Regenerative Medicine.

12 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Therapeutic strategies targeting Alzheimer's disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However the therapeutic efficacy for a single target is not ideal.

8 Aug 2016

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era.

8 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

Bochum-based scientists explore regeneration measures for athletes in elite sports

In a joint project, Bochum-based researchers headed by Prof Dr Alexander Ferrauti and Prof Dr Michael Kellmann studied the best possible regeneration measures for athletes after strenuous training and competition phases.

2 Aug 2016

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to cocaine addiction.

2 Aug 2016

Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

Researchers at the Johns Hopkins Kimmel Cancer Center say they have developed a system that uses transformed human stem cells to speed up screening of existing drugs that might work against rare brain and other cancers.

2 Aug 2016

Embryonic stem cell gene Nanog holds potential for reversing effects of aging

The fountain of youth may reside in an embryonic stem cell gene named Nanog.

26 Jul 2016

Common drug for type 2 diabetes may play surprising role in preventing preterm birth

Metformin, a medication routinely used by millions of people with type 2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, according to research findings published July 25.

26 Jul 2016

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process.

20 Jul 2016

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Scientists from A*STAR's Genome Institute of Singapore and the Cancer Science Institute of Singapore at the National University of Singapore came together to understand how EZH2, a cancer-promoting gene which is known to be involved in many types of cancers, is activated in breast cancer and lymphomas.

19 Jul 2016

Modifications to RUNX3 protein may promote cancer progression

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered that modifications to a protein called RUNX3 may promote cancer progression.

18 Jul 2016

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Cancer remains a leading cause of death worldwide, and the global cancer burden is expected to increase by 70 percent over the next two decades.

14 Jul 2016

Researchers identify PKD1 protein as potential cause for impaired insulin signaling in diabetics

Medication can help trigger the enzyme that kick starts insulin production in the body, but the drugs don't always work for those who are obese or diabetic, and most need to regulate their glucose and insulin levels. That's why a recent discovery made by Rudy Valentine and a team of researchers holds so much promise.

13 Jul 2016

Kinase News and Research

Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

Researchers reveal first three-dimensional molecular map of protein linked to many cancers

Study shows leptomeningeal metastases more prevalent in NSCLC patients with EGFR mutations

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

Cold plasma could help bones heal faster, study shows

Novel computational analysis of prostate cancer suggests potential targets for therapy

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

Bochum-based scientists explore regeneration measures for athletes in elite sports

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

Embryonic stem cell gene Nanog holds potential for reversing effects of aging

Common drug for type 2 diabetes may play surprising role in preventing preterm birth

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Modifications to RUNX3 protein may promote cancer progression

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Researchers identify PKD1 protein as potential cause for impaired insulin signaling in diabetics

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

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