Malignant News and Research

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Researchers create novel model that reveals cellular, molecular events driving leukemia progression

Mount Sinai researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic interventions at each stage, according to a study to be published in Cell Stem Cell.

16 Feb 2017

Radiotherapy for breast cancer linked to greater risk of second primary lung cancer

East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.

16 Feb 2017

Analyzing copies of genes may offer new therapeutic approaches for ovarian cancer

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics -- an alteration that results in the loss or gain in a copy of a gene.

15 Feb 2017

Professor aims to develop shortcuts for targeted and effective cancer therapy

The aim is to identify precisely the one drug, or the correct combination of drugs, that are most effective against the specific tumor present in each patient. Professor hopes that new tools will come into use in the next five years.

13 Feb 2017

False positives from mammogram screening can be detrimental to future care

A study conducted by the University of Illinois, Chicago, and published this week by the American Association for Cancer Research, indicates that women who experience a false positive after mammogram screening are more likely to delay or avoid future screening appointments.

10 Feb 2017

Researchers develop computer machine-learning model to predict remission or relapse in AML patients

Researchers have developed the first computer machine-learning model to accurately predict which patients diagnosed with acute myelogenous leukemia, or AML, will go into remission following treatment for their disease and which will relapse.

9 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

NIH researchers identify genes that may predict how melanoma spreads

Cancerous tumors are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

8 Feb 2017

New study uncovers important links between glioblastoma and epileptic seizures

Detecting brain tumors at the earliest possible stage and eliminating them before seizures begin might be possible one day, according to research by scientists at Baylor College of Medicine and Texas Children's Hospital.

7 Feb 2017

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

A team led by researchers of the Institute of Biomedicine of the University of Barcelona and the Research Institute of the Hospital de la Santa Creu i Sant Paushows for the first time, the three-dimensional structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years.

6 Feb 2017

Yale researchers identify new genetic defect in brain tumor cells that prevents DNA repair

In a new study, Yale Cancer Center researchers identified a novel genetic defect that prevents brain tumor cells from repairing damaged DNA.

3 Feb 2017

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

Two new clinical trials for pediatric brain cancer have begun at The University of Texas Health Science Center at Houston and Children's Memorial Hermann Hospital.

31 Jan 2017

Research provides insight into how melanoma and other cancers spread from solid tumors

In a second human case, a Yale-led research team has found that a melanoma cell and a white blood cell can fuse to form a hybrid with the ability to metastasize. The finding provides further insight into how melanoma and other cancers spread from solid tumors with implications for future treatment.

30 Jan 2017

Researchers predict melanoma death rates will decrease from current levels by 2050

By 2050 the death rates from malignant melanoma will have decreased from their current levels but the numbers of people dying from the disease will have increased due to the aging of populations.

30 Jan 2017

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

Pulmospheres, three dimensional multicellular spheroids composed of lung cells from individual patients, were shown to be effective in predicting the efficacy of medications for idiopathic pulmonary fibrosis, according to findings from University of Alabama at Birmingham scientists presented today in JCI Insight, a journal of the American Society for Clinical Investigation.

27 Jan 2017

New study explores how protein production goes off script when skin cells turn cancerous

Each cell in the body follows a strict protocol for manufacturing the proteins it needs to function.

27 Jan 2017

Deaths from diabetes in the U.S. higher than estimated, study shows

The proportion of deaths attributable to diabetes in the U.S. is as high as 12 percent - three times higher than estimates based on death certificates suggest, according to a new analysis led by a Boston University School of Public Health researcher.

27 Jan 2017

AI algorithm as good as dermatologists at spotting skin cancer

Researchers have developed an algorithm that matches or exceeds the ability of dermatologists to diagnose skin cancer, according to a new study. The study authors hope the technology can be integrated into Smartphones, to improve access to medical care.

26 Jan 2017

New project aims to improve efficiency of cytostatic drugs used in cancer treatment

Wilfried Weber, Professor of Synthetic Biology at the University of Freiburg, has received a grant of roughly €150,000 for his project "Hide and Seek with Cancer Drugs" in which he is working to improve the drugs used in cancer treatment

25 Jan 2017

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers.

24 Jan 2017

Malignant News and Research

Researchers create novel model that reveals cellular, molecular events driving leukemia progression

Radiotherapy for breast cancer linked to greater risk of second primary lung cancer

Analyzing copies of genes may offer new therapeutic approaches for ovarian cancer

Professor aims to develop shortcuts for targeted and effective cancer therapy

False positives from mammogram screening can be detrimental to future care

Researchers develop computer machine-learning model to predict remission or relapse in AML patients

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

NIH researchers identify genes that may predict how melanoma spreads

New study uncovers important links between glioblastoma and epileptic seizures

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

Yale researchers identify new genetic defect in brain tumor cells that prevents DNA repair

UTHealth and Children's Memorial Hermann begin two new clinical trials for pediatric brain cancer

Research provides insight into how melanoma and other cancers spread from solid tumors

Researchers predict melanoma death rates will decrease from current levels by 2050

Pulmospheres could serve as personalized, predictive model for assessing effect of IPF drugs

New study explores how protein production goes off script when skin cells turn cancerous

Deaths from diabetes in the U.S. higher than estimated, study shows

AI algorithm as good as dermatologists at spotting skin cancer

New project aims to improve efficiency of cytostatic drugs used in cancer treatment

Tulane researchers discover cancer-causing role of protein thought to be tumor suppressor

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