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Study provides link between common mutations in blood cells of older adults and atherosclerosis

A new study provides some of the first links between relatively common mutations in the blood cells of elderly humans and atherosclerosis.

19 Jan 2017

CeMM scientists develop new method by integrating CRISPR genome editing with single-cell sequencing

Genome editing using CRISPR/Cas9 "gene scissors" is a powerful tool for biological discovery and for identifying novel drug targets.

19 Jan 2017

UC biologists use frog models to study how early stressors may play role in onset of adult diseases

UC biologists have turned to amphibian sources -- specifically frogs and tadpoles -- to help shed light on how early stressors in the womb and shortly after birth may play a part in the onset of adult diseases such as diabetes and cardiovascular disease.

19 Jan 2017

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

A novel national trial for people with no established alternative to treat their rare cancers is being co-led by Northwestern Medicine investigators, who helped conceive of and develop the project.

19 Jan 2017

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

Selonterra LLC, a biotechnology company discovering therapies for Alzheimer’s disease and Parkinson’s disease announced the publication of the article “Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease” in Scientific Reports, a peer-reviewed journal of the Nature Publishing Group.

19 Jan 2017

New research provides insight into how estrogen modulates fear learning

Low estrogen levels may make women more susceptible to the development of post-traumatic stress disorder (PTSD) at some points in their menstrual cycles or lifetimes, while high estrogen levels may be protective.

19 Jan 2017

Researchers explore ins and outs of genome sequencing in newborns

When you have a baby, a nurse or a phlebotomist performs a heel stick to take a few drops of blood from your infant and sends it off to a state lab for a battery of tests.

19 Jan 2017

‘Collateral lethality’ may create new therapeutic options for several cancers

Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as "collateral lethality," which may create new options for development of therapies for several cancers.

19 Jan 2017

Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Neurodevelopmental disorders like autism very likely have their origin at the dawn of life, with the emergence of inappropriate connectivity between nerve cells in the brain.

19 Jan 2017

Scientists unravel new genetic immunodeficiency that makes children vulnerable to mild illnesses

A team of scientists led by prof. Adrian Liston and prof. Isabelle Meyts were able to characterize a new genetic immunodeficiency resulting from a mutation in a gene named STAT2.

18 Jan 2017

TGen scientists identify potent inhibitory compound for treatment against glioblastoma

A study led by scientists at the Translational Genomics Research Institute has identified "a potent inhibitory compound" in the elusive hunt for an improved treatment against glioblastoma, the most common and deadly type of adult brain cancer.

18 Jan 2017

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

An enzyme identified in Saccharomyces cerevisiae, commonly known as brewer's or baker's yeast, has passed in vitro trials, demonstrating its capacity to kill acute lymphoblastic leukemia (ALL) cells.

18 Jan 2017

Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Researchers at Trinity College Dublin have made exciting new findings that could offer a means of fighting resistance to treatment for people with oesophageal cancer.

18 Jan 2017

Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

Researchers from the Genes and Cancer research group at the Bellvitge Biomedical Research Institute have identified inactivating mutations in a number of genes that code for HLA-I histocompatibility complex proteins, which are involved in the immune response and can condition the tesponse of lung cancer patients to immunotherapy.

18 Jan 2017

COGENT scientists uncover genes responsible for cognitive ability

An international team of scientists, led by Todd Lencz, PhD, professor at The Feinstein Institute for Medical Research at Northwell Health and Hofstra Northwell School of Medicine, have unlocked some of the genes responsible for cognitive ability.

17 Jan 2017

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

17 Jan 2017

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs) -- treatment-resistant cells responsible for cancer recurrence and metastasis -- in breast cancer, as well as a compound that appears to reduce the molecule's ability to protect TICs from the effects of chemotherapy.

17 Jan 2017

Drug-resistant deadly bacteria more widespread than previously thought, study finds

A family of highly drug-resistant and potentially deadly bacteria may be spreading more widely--and more stealthily -- than previously thought, according to a new study from Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard.

17 Jan 2017

Knowledge bank approach could help find best treatment option for AML patients

An international collaboration led by clinical researchers at the Wellcome Trust Sanger Institute has shown proof-of-concept that truly personalised therapy will be possible in the future for people with cancer.

17 Jan 2017

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics.

16 Jan 2017

Genetic News and Research

Study provides link between common mutations in blood cells of older adults and atherosclerosis

CeMM scientists develop new method by integrating CRISPR genome editing with single-cell sequencing

UC biologists use frog models to study how early stressors may play role in onset of adult diseases

Northwestern Medicine investigators to lead clinical trial for people with rare cancers

Selonterra publishes article on novel APOE4 mechanism linked to Alzheimer’s disease

New research provides insight into how estrogen modulates fear learning

Researchers explore ins and outs of genome sequencing in newborns

‘Collateral lethality’ may create new therapeutic options for several cancers

Researchers show how adult learning is impaired in females using mouse models of Rett syndrome

Scientists unravel new genetic immunodeficiency that makes children vulnerable to mild illnesses

TGen scientists identify potent inhibitory compound for treatment against glioblastoma

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

Research findings could offer ways of fighting treatment resistance in oesophageal cancer

Inactive B2M genes can condition response of lung cancer patients to immunotherapy, study shows

COGENT scientists uncover genes responsible for cognitive ability

Epigenetic changes drive successful metastases of pancreatic cancer cells

MGH researchers identify protein that may protect tumor-initiating cells in breast cancer

Drug-resistant deadly bacteria more widespread than previously thought, study finds

Knowledge bank approach could help find best treatment option for AML patients

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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