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Stress circuits in brain undergo profound learning early in life

Researchers at the University of Calgary's Hotchkiss Brain Institute have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, Jaideep Bains, PhD, and colleagues have shown stress circuits are capable of self-tuning following a single stress.

8 Apr 2013

Nektar Therapeutics presents positive results for NKTR-214 at AACR Annual Meeting

Nektar Therapeutics today presented positive preclinical data for NKTR-214, a novel cancer immunotherapy which targets the IL-2 receptor complex, at the 2013 American Association for Cancer Research Annual Meeting.

8 Apr 2013

Dual-signaling CAR T cells show potent anti-cancer activity in animal model

The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs.

8 Apr 2013

Study: Altering brain activity with laser light eliminates addictive behavior in rats

By stimulating one part of the brain with laser light, researchers at the National Institutes of Health (NIH) and the Ernest Gallo Clinic and Research Center at UC San Francisco (UCSF) have shown that they can wipe away addictive behavior in rats - or conversely turn non-addicted rats into compulsive cocaine seekers.

4 Apr 2013

Study shows relationship between cocaine-induced brain deficits in prefrontal cortex and cocaine-seeking

Could drug addiction treatment of the future be as simple as an on/off switch in the brain? A study in rats has found that stimulating a key part of the brain reduces compulsive cocaine-seeking and suggests the possibility of changing addictive behavior generally.

4 Apr 2013

Study suggests rats can be used as animal model to investigate human brain

A study led by Zachary Mainen, Director of the Champalimaud Neuroscience Programme, and published today (March 28th) in the scientific journal, Neuron, reports that when rats were challenged with a series of perceptual decision problems.

29 Mar 2013

Inflammation and epigenetics: an interview with Dr Belkina and Dr Denis, Boston University School of Medicine

Inflammation can be thought of as taking two major forms: acute or chronic. Acute inflammation, which can be painful, usually arises quickly and resolves quickly. It accompanies bacterial infections, traumatic injury and is useful to fight infections and promote healing.

28 Mar 2013

New research may shed light on alcohol addiction vulnerability in some people

A Wake Forest Baptist Medical Center team studying alcohol addiction has new research that might shed light on why some drinkers are more susceptible to addiction than others.

27 Mar 2013

Eating behavior could act as defense mechanism against infections and autoimmune disorders

Neurons that control hunger in the central nervous system also regulate immune cell functions, implicating eating behavior as a defense against infections and autoimmune disease development, Yale School of Medicine researchers have found in a new study published in the Proceedings of the National Academy of Sciences (PNAS).

26 Mar 2013

LMU researchers identify microRNA that offers promising target for new therapies

Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet in Munich have now identified a microRNA that plays a prominent role in the process, and offers a promising target for new therapies.

25 Mar 2013

Research findings could lead to new therapeutic strategy for heart failure

New research from UC Davis published in the Proceedings of the National Academy of Sciences shows that blocking an enzyme that promotes inflammation can prevent the tissue damage following a heart attack that often leads to heart failure.

24 Mar 2013

Gene LY86 identified as likely contributor to obesity

Food and environment can chemically alter your gene function and scientists have identified a gene that is consistently altered in obesity.

22 Mar 2013

Dysfunction of Calcium channel in neurons of cerebellum causes different motor diseases

A dysfunction of a certain Calcium channel, the so called P/Q-type channel, in neurons of the cerebellum is sufficient to cause different motor diseases as well as a special type of epilepsy.

22 Mar 2013

Study reveals treatments for pain at site of injury may not always be good enough

Treatments for pain at the site of an injury may not always be good enough, according to a novel study by University of Maryland (UM) scientists reported March 20 in The Journal of Neuroscience.

21 Mar 2013

Research findings could lead to development of new drugs for gout treatment

Findings from a Loyola University Chicago Stritch School of Medicine study could lead to the development of new drugs to treat gout.

20 Mar 2013

Researchers: Acupuncture can reduce stress hormone response in animal model of chronic stress

While acupuncture is used widely to treat chronic stress, the mechanism of action leading to reported health benefits are not understood. In a series of studies at Georgetown University Medical Center, researchers are demonstrating how acupuncture can significantly reduce the stress hormone response in an animal model of chronic stress.

15 Mar 2013

Studies show protein semaphorin 3A helps detect acute kidney injury

A guidance cue that helps kidneys form may also be a red flag that they are in danger, researchers report.

13 Mar 2013

Researchers develop new approach to screening potential treatments for Alzheimer's disease

According to a 2012 World Health Organization report, over 35 million people worldwide currently have dementia, a number that is expected to double by 2030 (66 million) and triple by 2050 (115 million).

11 Mar 2013

Salt can induce and worsen pathogenic immune system responses in mice

For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale School of Medicine, Harvard Medical School and the Broad Institute have identified a prime suspect in the mystery - dietary salt.

7 Mar 2013

Scientists pinpoint neural basis for stress-related relapse in rat models

All too often, stress turns addiction recovery into relapse, but years of basic brain research have provided scientists with insight that might allow them develop a medicine to help. A new study in the journal Neuron pinpoints the neural basis for stress-related relapse in rat models to an unprecedented degree.

7 Mar 2013

Animal Model News and Research

Stress circuits in brain undergo profound learning early in life

Nektar Therapeutics presents positive results for NKTR-214 at AACR Annual Meeting

Dual-signaling CAR T cells show potent anti-cancer activity in animal model

Study: Altering brain activity with laser light eliminates addictive behavior in rats

Study shows relationship between cocaine-induced brain deficits in prefrontal cortex and cocaine-seeking

Study suggests rats can be used as animal model to investigate human brain

Inflammation and epigenetics: an interview with Dr Belkina and Dr Denis, Boston University School of Medicine

New research may shed light on alcohol addiction vulnerability in some people

Eating behavior could act as defense mechanism against infections and autoimmune disorders

LMU researchers identify microRNA that offers promising target for new therapies

Research findings could lead to new therapeutic strategy for heart failure

Gene LY86 identified as likely contributor to obesity

Dysfunction of Calcium channel in neurons of cerebellum causes different motor diseases

Study reveals treatments for pain at site of injury may not always be good enough

Research findings could lead to development of new drugs for gout treatment

Researchers: Acupuncture can reduce stress hormone response in animal model of chronic stress

Studies show protein semaphorin 3A helps detect acute kidney injury

Researchers develop new approach to screening potential treatments for Alzheimer's disease

Salt can induce and worsen pathogenic immune system responses in mice

Scientists pinpoint neural basis for stress-related relapse in rat models

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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